Clinical and forensic signs related to cocaine abuse

Current Drug Abuse Reviews

Volumn 5, Issue 1, 2012, Pages 64-83

  Dinis Oliveira, Ricardo Jorge ^a,b,c,d,e   Carvalho, Félix ^e   Duarte, José Alberto ^e   Proença, Jorge Brandão ^a,b   Santos, Agostinho ^c,d,f   Magalhães, Teresa ^c,d,e,f  

^a Inst Politec de Saude Do N Coop de Ensino Superior Politecnico e Universitario: IPSN CESPU   (Portugal)

^b UNIVERSITY INSTITUTE OF HEALTH SCIENCES IUCS   (Portugal)

^c University of Porto   (Portugal)

^d UNIVERSITY OF COIMBRA   (Portugal)

^e UNIVERSITY OF PORTO   (Portugal)

^f National Institute of Legal Medicine   (Portugal)

Author keywords

"Crack lung"; Angioneurotic edema; Cocaine; Dental health; Intracerebral and peripheric hemorrhages; Midline destructive lesion; Necrosis and gangrene of extremities; Non biological evidences; Pseudoscleradermatous triad and "crack hands"; Reticular purpura; Rhabdomyolysis

Indexed keywords

COCAINE; LEVAMISOLE;

ACUTE TOXICITY; ADJUVANT THERAPY; ANGIONEUROTIC EDEMA; ARTICLE; BLEEDING; BRAIN HEMORRHAGE; BREAST CANCER; CHRONIC TOXICITY; CIGARETTE SMOKING; CLINICAL DECISION MAKING; CLINICAL FEATURE; CLINICAL LABORATORY; COCAINE DEPENDENCE; COLORECTAL CANCER; CRACK HAND; CRACK LUNG; DISEASE COURSE; FORENSIC TOXICOLOGY; GANGRENE; GASTROINTESTINAL DISEASE; HAND DISEASE; HUMAN; LIVER DISEASE; LUNG DISEASE; MIDLINE DESTRUCTIVE LESION; PERIPHERAL HEMORRHAGE; PRIORITY JOURNAL; PSEUDOSCLERADERMATOUS TRIAD; PURPURA; RETICULAR PURPURA; RHABDOMYOLYSIS; SKIN MANIFESTATION; SKIN NECROSIS; TOOTH DISEASE;

EID: 84860286519     PISSN: 18744737     EISSN: 18744745     Source Type: Journal    
DOI: 10.2174/1874473711205010064     Document Type: Article

References (121)

1. Goldstein RA, DesLauriers C, Burda AM. Cocaine: history, social implications, and toxicity--a review. Dis Mon 2009; 55: 6-38.
2. [Boghdadi MS, Henning RJ. Cocaine: pathophysiology and clinical toxicology. Heart Lung 1997; 26: 466-83; quiz 84-5.
3. Warner EA. Cocaine abuse. Ann Intern Med 1993; 119: 226-35.
4. Shannon M. Clinical toxicity of cocaine adulterants. Ann Emerg Med 1988; 17: 1243-7.
5. Cunha-Oliveira T, Rego C, Carvalho F, Oliveira C. Medical Toxicology of Drugs of Abuse. Encyclopedia of Addictive Behaviors 2011; (in press).
6. Katzung BG, Masters SB, Trevor AJ, Eds. Basic & Clinical Pharmacology. New York: McGraw-Hill Medical 2009.
7. Seyer BA, Grist W, Muller S. Aggressive destructive midfacial lesion from cocaine abuse. Oral Surg Oral Med Oral Pathol Oral Radiol Endodont 2002; 94: 465-70.
8. Smith JC, Kacker A, Anand VK. Midline nasal and hard palate destruction in cocaine abusers and cocaine's role in rhinologic practice. Ear NoseThroat J 2002; 81: 172-7.
9. Mari A, Arranz C, Gimeno X, et al. Nasal cocaine abuse and centrofacial destructive process: report of three cases including treatment. Oral Surg Oral Med Oral Pathol Oral Radiol Endodont 2002; 93: 435-9.
10. Maloney WJ. The significance of cocaine use to dental practice. New York State Dental J 2010; 76: 36-9.
11. Brewer JD, Meves A, Bostwick JM, Hamacher KL, Pittelkow MR. Cocaine abuse: dermatologic manifestations and therapeutic approaches. J Am Acad Dermatol 2008; 59: 483-7.
12. Dinis-Oliveira RJ, Caldas I, Carvalho F, Magalhaes T. Bruxism after 3,4-methylenedioxymethamphetamine (ecstasy) abuse. Clin Toxicol (Phila) 2010; 48: 863-4.
13. Payne-James JJ, Munro MH, Rowland Payne CM. Pseudosclerodermatous triad of perniosis, pulp atrophy and 'parrotbeaked' clawing of the nails--a newly recognized syndrome of chronic crack cocaine use. J Forensic Leg Med 2007; 14: 65-71.
14. Dhawan SS, Wang BW. Four-extremity gangrene associated with crack cocaine abuse. Ann Emerg Med 2007; 49(2): 186-9.
15. Walsh NM, Green PJ, Burlingame RW, Pasternak S, Hanly JG. Cocaine-related retiform purpura: evidence to incriminate the adulterant, levamisole. J Cutan Pathol 2010; 37(12): 1212-9.
16. Konzen JP, Levine SR, Garcia JH. Vasospasm and thrombus formation as possible mechanisms of stroke related to alkaloidal cocaine. Stroke 1995; 26(6): 1114-8.
17. Bruno A, Nolte KB, Chapin J. Stroke associated with ephedrine use. Neurology. 1993; 43: 1313-6.
18. Lingamfelter DC, Knight LD. Sudden death from massive gastrointestinal hemorrhage associated with crack cocaine use: case report and review of the literature. Am J Forensic Med Pathol 2010; 31: 98-9.
19. Kinsey CM, Howell M. A 27-year-old woman with a swollen uvula, chest pain, and elevated creatinine phosphokinase levels. Chest 2008; 133: 809-11.
20. Ruttenber AJ, McAnally HB, Wetli CV. Cocaine-associated rhabdomyolysis and excited delirium: different stages of the same syndrome. Am J Forensic Med Pathol 1999; 20: 120-7.
21. Kissner DG, Lawrence WD, Selis JE, Flint A. Crack lung: pulmonary disease caused by cocaine abuse. Am Rev Respir Dis 1987; 136: 1250-2.
22. Dinis-Oliveira RJ, Carvalho F, Duarte JA, et al. Collection of biological samples in forensic toxicology. Toxicol Mech Methods 2010; 20: 363-414.
23. Talbott JF, Gorti GK, Koch RJ. Midfacial osteomyelitis in a chronic cocaine abuser: a case report. Ear Nose Throat J 2001; 80: 738-40, 42-3.
24. Schweitzer VG. Osteolytic sinusitis and pneumomediastinum: deceptive otolaryngologic complications of cocaine abuse. Laryngoscope 1986; 96: 206-10.
25. Sastry RC, Lee D, Har-El G. Palate perforation from cocaine abuse. Otolaryngol Head Neck Surg 1997; 116: 565-6.
26. Deutsch HL, Millard DR, Jr. A new cocaine abuse complex. Involvement of nose, septum, palate, and pharynx. Arch Otolaryngol Head Neck Surg 1989; 115: 235-7.
27. Valeriani M, Mezzana P. Cocaine sniffing immediately after rhinoseptoplasty. Plast Reconstr Surg 2001; 107: 1921.
28. Wehrens KM, Hawinkels H, Fresow RN, van der Hulst RR, Boeckx WD. Reconstruction of the nose after cocaine abuse. J Plast Reconstr Aesthet Surg 2009; 62: 532-4.
29. Brand HS, Gonggrijp S, Blanksma CJ. Cocaine and oral health. Br Dental J 2008; 204: 365-9.
30. Kapila YL, Kashani H. Cocaine-associated rapid gingival recession and dental erosion. A case report. J Periodontol 1997; 68: 485-8.
31. Krutchkoff DJ, Eisenberg E, O'Brien JE, Ponzillo JJ. Cocaineinduced dental erosions. N Engl J Med 1990; 322: 408.
32. Reece AS. Dentition of addiction in Queensland: poor dental status and major contributing drugs. Aust Dental J 2007; 52: 144-9.
33. Duxbury AJ. Ecstasy--dental implications. Br Dental J 1993; 175: 38.
34. Pellegrini M, Casa A, Marchei E, et al. Development and validation of a gas chromatography-mass spectrometry assay for opiates and cocaine in human teeth. J Pharm Biomed Anal 2006; 40: 662-8.
35. Rees TD. Oral effects of drug abuse. Crit Rev Oral Biol Med 1992; 3: 163-84.
36. Burday MJ, Martin SE. Cocaine-associated thrombocytopenia. Am J Med 1991; 91: 656-60.
37. Abd El-Rahman AM, Ammar H. Cocaine-induced acute hepatitis and thrombotic microangiopathy. JAMA 2005; 293: 2715; author reply -6.
38. Balaguer F, Fernandez J, Lozano M, Miquel R, Mas A. Cocaineinduced acute hepatitis and thrombotic microangiopathy. JAMA 2005; 293: 797-8.
39. Burke AP, Mont E, Kolodgie F, Virmani R. Thrombotic thrombocytopenic purpura causing rapid unexpected death: value of CD61 immunohistochemical staining in diagnosis. Cardiovasc Pathol 2005; 14: 150-5.
40. Driscoll SE. A pattern of erosive carious lesions from cocaine use. J Massachusetts Dental Soc 2003; 52: 12-4.
41. Friedlander AH, Gorelick DA. Dental management of the cocaine addict. Oral Surg Oral Med Oral Pathol 1988; 65: 45-8.
42. Gontijo B, Bittencourt FV, Lourenço LFS. Skin manifestations of illicit drug use. Anais Brasileiros de Dermatol 2006; 81: 307-17.
43. Lin M. Images in emergency medicine. Fingertip burns from a crack pipe. Ann Emerg Med 2008; 51: 681, 95.
44. Gatof D, Albert RK. Bilateral thumb burns leading to the diagnosis of crack lung. Chest 2002; 121: 289-91.
45. Chevalier X, Rostoker G, Larget-Piet B, Gherardi R. Schoenlein-Henoch purpura with necrotizing vasculitis after cocaine snorting. Clin Nephrol 1995; 43: 348-9.
46. Panchbhavi VK, Leontaritis NM. A case report of atypical magnetic resonance images of the hindfoot following cocaine injection in the foot and a review of osteonecrosis in calcaneus. Foot Ankle Surg 2008; 14: 215-20.
47. Friedman DR, Wolfsthal SD. Cocaine-induced pseudovasculitis. Mayo Clin Proc 2005; 80: 671-3.
48. Hofbauer GF, Hafner J, Trueb RM. Urticarial vasculitis following cocaine use. Br J Dermatol 1999; 141: 600-1.
49. Milman N, Smith CD. Cutaneous vasculopathy associated with cocaine use. Arthritis Care Res (Hoboken) 2011; 63: 1195-202.
50. Orriols R, Munoz X, Ferrer J, Huget P, Morell F. Cocaine-induced Churg-Strauss vasculitis. Eur Respir J 1996; 9: 175-7.
51. Noel B. Cocaine and arsenic-induced Raynaud's phenomenon. Clin Rheumatol 2002; 21: 343-4.
52. Balbir-Gurman A, Braun-Moscovici Y, Nahir AM. Cocaine-Induced raynaud's phenomenon and ischaemic finger necrosis. Clin Rheumatol 2001; 20: 376-8.
53. Gertner E, Hamlar D. Necrotizing granulomatous vasculitis associated with cocaine use. J Rheumatol 2002; 29: 1795-7.
54. Lu LK, High WA. Acute generalized exanthematous pustulosis caused by illicit street drugs? Arch Dermatol 2007; 143: 430-1.
55. Hofbauer GF, Burg G, Nestle FO. Cocaine-related Stevens-Johnson syndrome. Dermatology 2000; 201: 258-60.
56. Del Giudice P. Cutaneous complications of intravenous drug abuse. Br J Dermatol 2004; 150: 1-10.
57. Del Giudice P, Vandenbos F, Boissy C, et al. Cutaneous complications of direct intra-arterial injections in drug addicts. Acta Dermato-Venereolog 2005; 85: 451-2.
58. Lange RA, Hillis LD. Cardiovascular complications of cocaine use. N Engl J Med 2001; 345: 351-8.
59. [Menon DV, Wang Z, Fadel PJ, et al. Central sympatholysis as a novel countermeasure for cocaine-induced sympathetic activation and vasoconstriction in humans. J Am Coll Cardiol 2007; 50: 626-33.
60. Vongpatanasin W, Mansour Y, Chavoshan B, Arbique D, Victor RG. Cocaine stimulates the human cardiovascular system via a central mechanism of action. Circulation 1999; 100: 497-502.
61. Vongpatanasin W, Taylor JA, Victor RG. Effects of cocaine on heart rate variability in healthy subjects. Am J Cardiol 2004; 93(3): 385-8.
62. Isner JM, Chokshi SK. Cocaine and vasospasm. N Engl J Med 1989; 321: 1604-6.
63. Moliterno DJ, Lange RA, Gerard RD, Willard JE, Lackner C, Hillis LD. Influence of intranasal cocaine on plasma constituents associated with endogenous thrombosis and thrombolysis. Am J Med 1994; 96: 492-6.
64. Ellis CN, McAlexander WW. Enterocolitis associated with cocaine use. Dis Colon Rectum 2005; 48: 2313-6.
65. Grudell AB, Mueller PS, Viggiano TR. Black esophagus: report of six cases and review of the literature, 1963-2003. Dis Esophagus 2006; 19: 105-10.
66. Chen KR, Carlson JA. Clinical approach to cutaneous vasculitis. Am J Clin Dermatol 2008; 9: 71-92.
67. Fthenakis A, Klein PA. Retiform purpura in a patient with a history of cocaine use. Dermatology Online J 2011; 17: 12.
68. Rowshani AT, Schot LJ, ten Berge IJ. c-ANCA as a serological pitfall. Lancet 2004; 363: 782.
69. Wiesner O, Russell KA, Lee AS, et al. Antineutrophil cytoplasmic antibodies reacting with human neutrophil elastase as a diagnostic marker for cocaine-induced midline destructive lesions but not autoimmune vasculitis. Arthritis Rheum 2004; 50: 2954-65.
70. Grau R. Pseudovasculitis: mechanisms of vascular injury and clinical spectrum. Curr Rheumatol Rep 2002; 4: 83-9.
71. Mouraviev VB, Pautler SE, Hayman WP. Fournier's gangrene following penile self-injection with cocaine. Scand J Urol Nephrol 2002; 36: 317-8.
72. Carey F, Dinsmore WW. Cocaine-induced penile necrosis. Int J STD Aids 2004; 15: 424-5.
73. Chan JY, Huang CL, Chan SH. Nitric oxide as a mediator of cocaine-induced penile erection in the rat. Br J Pharmacol 1996; 118: 155-61.
74. Chen SC, Jang MY, Wang CS, et al. Cocaine-related vasculitis causing scrotal gangrene. Ann Pharmacother 2009; 43: 375-8.
75. Bruno A. Cerebrovascular complications of alcohol and sympathomimetic drug abuse. Curr Neurol Neurosci Rep 2003; 3: 40-5.
76. Levine SR, Brust JC, Futrell N, et al. A comparative study of the cerebrovascular complications of cocaine: alkaloidal versus hydrochloride--a review. Neurology 1991; 41: 1173-7.
77. Shvartsbeyn M, Phillips DG, Markey MA, Morrison A, DeJong JL, Castellani RJ. Cocaine-induced intracerebral hemorrhage in a patient with cerebral amyloid angiopathy. J Forensic Sci 2010; 55: 1389-92.
78. Daras M, Tuchman AJ, Koppel BS, Samkoff LM, Weitzner I, Marc J. Neurovascular complications of cocaine. Acta Neurol Scand 1994; 90: 124-9.
79. Egido-Herrero JA, Gonzalez JL. Pontine hemorrhage after abuse of cocaine. Letter. Rev Neurol 1997; 25: 137-8.
80. Vallee JN, Crozier S, Guillevin R, et al. Acute basilar artery occlusion treated by thromboaspiration in a cocaine and ecstasy abuser. Neurology 2003; 61: 839-41.
81. Ramadan NM, Levine SR, Welch KM. Pontine hemorrhage following "crack" cocaine use. Neurology 1991; 41: 946-7.
82. Martin-Schild S, Albright KC, Hallevi H, et al. Intracerebral hemorrhage in cocaine users. Stroke 2010; 41: 680-4.
83. Reynolds BC, Penman DK, Howatson AG, Jackson LA, Skeoch CH. Multifocal multi-organ ischaemia and infarction in a preterm baby due to maternal intravenous cocaine use: a case report. J Med Case Reports 2009; 3: 9259.
84. Reynolds BC, Penman DM, Howatson AG, Jackson LA, Skeoch CH. Multifocal multi-organ ischaemia and infarction in a preterm baby due to maternal intravenous cocaine use: a case report. J Med Case Reports 2009; 3: 9324.
85. Muniz AE, Evans T. Acute gastrointestinal manifestations associated with use of crack. Am J Emerg Med 2001; 19(1): 61-3.
86. Hidalgo Mora JJ, Gimenez de Llano E, Sempere Verdu E, Feliu Sagala M. Uvular angioedema after intranasal cocaine consumption. Med Clin (Barc) 2002; 119: 438-9.
87. Kestler A, Keyes L. Images in clinical medicine. Uvular angioedema (Quincke's disease). N Engl J Med 2003; 349: 867.
88. Macfarlane R, Hart J, Henry JA. A man with a massive uvula. Lancet 2002; 359: 492.
89. Welling A. Enlarged uvula (Quincke's Oedema)--a side effect of inhaled cocaine?--A case study and review of the literature. Int Emerg Nurs 2008; 16: 207-10.
90. Castro-Villamor MA, de las Heras P, Armentia A, Duenas-Laita A. Cocaine-induced severe angioedema and urticaria. Ann Emerg Med 1999; 34: 296-7.
91. Boyce SH, Quigley MA. Uvulitis and partial upper airway obstruction following cannabis inhalation. Emerg Med (Fremantle) 2002; 14: 106-8.
92. [Eede HV, Montenij LJ, Touw DJ, Norris EM. Rhabdomyolysis in MDMA intoxication: a rapid and underestimated killer. "clean" ecstasy: a safe party drug? J Emerg Med 2009; [Epub ahead of print].
93. Toth AR, Varga T. Myocardium and striated muscle damage caused by licit or illicit drugs. Leg Med (Tokyo) 2009; 11 (Suppl 1): S484-7.
94. Bailey ME, Fraire AE, Greenberg SD, Barnard J, Cagle PT. Pulmonary histopathology in cocaine abusers. Hum Pathol 1994; 25: 203-7.
95. Murray RJ, Smialek JE, Golle M, Albin RJ. Pulmonary artery medial hypertrophy in cocaine users without foreign particle microembolization. Chest 1989; 96: 1050-3.
96. Klinger JR, Bensadoun E, Corrao WM. Pulmonary complications from alveolar accumulation of carbonaceous material in a cocaine smoker. Chest 1992; 101: 1171-3.
97. Dinis-Oliveira RJ, Santos A, Magalhães T. "Foam cone" exuding from the mouth and nostrils following heroin overdose. Toxicol Mech Methods 2011; 22(2): 159-60.
98. Karch SB. Karch's pathology of drug abuse. 4th ed. Boca Raton: CRC Press 2009.
99. Skopp G. Preanalytic aspects in postmortem toxicology. Forensic Sci Int. 2004; 142: 75-100.
100. Karch SB. Postmortem toxicology of abused drugs. Boca Raton, FL: CRC Press 2008.
101. Dinis-Oliveira RJ, Magalhaes T, Carvalho F, Santos A. A cocaine body packer case report: clinical and forensic aspects. Clin Toxicol (Phila) 2009; 47: 590-1.
102. Hassanian-Moghaddam H, Abolmasoumi Z. Consequence of body packing of illicit drugs. Arch Iran Med 2007; 10: 20-3.
103. [Hergan K, Kofler K, Oser W. Drug smuggling by body packing: what radiologists should know about it. Eur Radiol 2004; 14: 736-42.
104. Smith FP. Handbook of forensic drugs analysis. In: Siegel JA, Ed. Burlington, MA: Elsevier Inc. 2005.
105. Scott LJ. Specific field test for cocaine. Microgram 1973; 6: 179-81.
106. Milroy CM, Parai JL. The histopathology of drugs of abuse. Histopathology 2011; 59: 579-93.
107. Lypka MA, Urata MM. Images in clinical medicine. Cocaineinduced palatal perforation. N Engl J Med 2007; 357: 1956.
108. Di Cosola M, Turco M, Acero J, Navarro-Vila C, Cortelazzi R. Cocaine-related syndrome and palatal reconstruction: report of a series of cases. Int J Oral Maxillofacial Surg 2007; 36: 721-7.
109. Cintra HL, Basile FV, Tournieux TT, Pitanguy I, Basile AR. Midline palate perforation secondary to cocaine abuse. J Plast Reconstr Aesthet Surg 2008; 61: 588-90.
110. Guyuron B, Afrooz PN. Correction of cocaine-related nasal defects. Plast Reconstr Surg 2008; 121: 1015-23.
111. Brusati R, Carota F, Mortini P, Chiapasco M, Biglioli F. A peculiar case of midface reconstruction with four free flaps in a cocaineaddicted patient. J Plast Reconstr Aesthet Surg 2009; 62: e33-40.
112. Iglesias ML, Epelde F, Berenguer A, Solernou X, Marinosa M, Campderrich E. Aseptic necrosis of the cutaneous fat and fascia after administration of intravenous cocaine. Rev Clin Esp 2011; 211: e63-5.
113. Reutemann P, Grenier N, Telang GH. Occlusive vasculopathy with vascular and skin necrosis secondary to smoking crack cocaine. J Am Acad Dermatol 2011; 64: 1004-6.
114. Roche E, Martinez-Menchon T, Sanchez-Carazo JL, Oliver V, Alegre de Miquel V. Two cases of eruptive pyoderma gangrenosum associated with cocaine use. Actas Dermosifiliogr 2008; 99: 727-30.
115. Altenburger DL, Wagner AS, Li S, Garavaglia J. A case of black esophagus with histopathologic description and characterization. Arch Pathol Lab Med 2011; 135: 797-8.
116. Muirhead TT, Eide MJ. Images in clinical medicine. Toxic effects of levamisole in a cocaine user. N Engl J Med 2011; 364: e52.
117. Ullrich K, Koval R, Koval E, Bapoje S, Hirsh JM. Five consecutive cases of a cutaneous vasculopathy in users of levamisoleadulterated cocaine. J Clin Rheumatol 2011; 17: 193-6.
118. Jenkins JM, Curwen T. Change in adolescents' internalizing symptomatology as a function of sex and the timing of maternal depressive symptomatology. J Am Acad Child Adolesc Psychiatry 2008; 47: 399-405.
119. Lung D, Lynch K, Agrawal S, Armenian P, Banh K. Images in emergency medicine. Adult female with rash on lower extremities. Vasculopathic purpura and neutropenia caused by levamisolecontaminated cocaine. Ann Emerg Med 2011; 57: 307, 11.
120. Lee BL, Stone JH, Gimbel D, Khosroshahi A. A 44-year-old woman with cutaneous bullae and extensive skin necrosis. Arthritis Care Res (Hoboken) 2010; 62: 1805-11.
121. Byard RW, Summersides G, Thompson A. Confluent muscle pallor: a macroscopic marker of cocaine-induced rhabdomyolysis. Forensic Sci Med Pathol 2011; 7: 364-6.