Complementary Chimeric Isoforms Reveal Dscam1 Binding Specificity In Vivo

Neuron

Volumn 74, Issue 2, 2012, Pages 261-268

  Wu, Wei ^a   Ahlsen, Goran ^b   Baker, David ^d   Shapiro, Lawrence ^b,c   Zipursky, Lawrence S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c New York Presbyterian Hospital   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHIMERIC PROTEIN; DSCAM1 PROTEIN; IMMUNOGLOBULIN; ISOPROTEIN; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; ANIMAL CELL; ANTIGEN RECOGNITION; ARTICLE; CELL FUNCTION; CHEMICAL ANALYSIS; CHIMERA; CONTROLLED STUDY; DROSOPHILA; DSCAM1 GENE; ENZYME SPECIFICITY; GENE; GENETIC ANALYSIS; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR DYNAMICS; NERVE POTENTIAL; NEURITE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTIGENS, CD; CELL ADHESION MOLECULES; CELL COMMUNICATION; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GREEN FLUORESCENT PROTEINS; IMMUNOGLOBULINS; MODELS, MOLECULAR; MUTANT CHIMERIC PROTEINS; MUTATION; PROTEIN BINDING; PROTEIN ISOFORMS; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; ULTRACENTRIFUGATION;

EID: 84860284421     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2012.02.029     Document Type: Article

References (26)

1. Boucard A.A., Chubykin A.A., Comoletti D., Taylor P., Südhof T.C. A splice code for trans-synaptic cell adhesion mediated by binding of neuroligin 1 to alpha- and beta-neurexins. Neuron 2005, 48:229-236.
2. Groth A.C., Fish M., Nusse R., Calos M.P. Construction of transgenic Drosophila by using the site-specific integrase from phage phiC31. Genetics 2004, 166:1775-1782.
3. Grueber W.B., Jan L.Y., Jan Y.N. Tiling of the Drosophila epidermis by multidendritic sensory neurons. Development 2002, 129:2867-2878.
4. Hartman P.E., Roth J.R. Mechanisms of suppression. Adv. Genet. 1973, 17:1-105.
5. Hattori D., Demir E., Kim H.W., Viragh E., Zipursky S.L., Dickson B.J. Dscam diversity is essential for neuronal wiring and self-recognition. Nature 2007, 449:223-227.
6. Hattori D., Millard S.S., Wojtowicz W.M., Zipursky S.L. Dscam-mediated cell recognition regulates neural circuit formation. Annu. Rev. Cell Dev. Biol. 2008, 24:597-620.
7. Hattori D., Chen Y., Matthews B.J., Salwinski L., Sabatti C., Grueber W.B., Zipursky S.L. Robust discrimination between self and non-self neurites requires thousands of Dscam1 isoforms. Nature 2009, 461:644-648.
8. Hughes M.E., Bortnick R., Tsubouchi A., Bäumer P., Kondo M., Uemura T., Schmucker D. Homophilic Dscam interactions control complex dendrite morphogenesis. Neuron 2007, 54:417-427.
9. Kidd T., Russell C., Goodman C.S., Tear G. Dosage-sensitive and complementary functions of roundabout and commissureless control axon crossing of the CNS midline. Neuron 1998, 20:25-33.
10. Kramer A.P., Kuwada J.Y. Formation of the receptive fields of leech mechanosensory neurons during embryonic development. J. Neurosci. 1983, 3:2474-2486.
11. Matthews B.J., Kim M.E., Flanagan J.J., Hattori D., Clemens J.C., Zipursky S.L., Grueber W.B. Dendrite self-avoidance is controlled by Dscam. Cell 2007, 129:593-604.
12. Meijers R., Puettmann-Holgado R., Skiniotis G., Liu J.H., Walz T., Wang J.H., Schmucker D. Structural basis of Dscam isoform specificity. Nature 2007, 449:487-491.
13. Neves G., Zucker J., Daly M., Chess A. Stochastic yet biased expression of multiple Dscam splice variants by individual cells. Nat. Genet. 2004, 36:240-246.
14. R Development Core Team. (2006). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. ISBN 3-900051-07-0, . http://www.R-project.org.
15. Sawaya M.R., Wojtowicz W.M., Andre I., Qian B., Wu W., Baker D., Eisenberg D., Zipursky S.L. A double S shape provides the structural basis for the extraordinary binding specificity of Dscam isoforms. Cell 2008, 134:1007-1018.
16. Schmucker D., Clemens J.C., Shu H., Worby C.A., Xiao J., Muda M., Dixon J.E., Zipursky S.L. Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity. Cell 2000, 101:671-684.
17. Schreiner D., Weiner J.A. Combinatorial homophilic interaction between gamma-protocadherin multimers greatly expands the molecular diversity of cell adhesion. Proc. Natl. Acad. Sci. USA 2010, 107:14893-14898.
18. Shapiro L., Love J., Colman D.R. Adhesion molecules in the nervous system: structural insights into function and diversity. Annu. Rev. Neurosci. 2007, 30:451-474.
19. Soba P., Zhu S., Emoto K., Younger S., Yang S.J., Yu H.H., Lee T., Jan L.Y., Jan Y.N. Drosophila sensory neurons require Dscam for dendritic self-avoidance and proper dendritic field organization. Neuron 2007, 54:403-416.
20. Südhof T.C. Neuroligins and neurexins link synaptic function to cognitive disease. Nature 2008, 455:903-911.
21. Wang J., Zugates C.T., Liang I.H., Lee C.H., Lee T. Drosophila Dscam is required for divergent segregation of sister branches and suppresses ectopic bifurcation of axons. Neuron 2002, 33:559-571.
22. Wojtowicz W.M., Flanagan J.J., Millard S.S., Zipursky S.L., Clemens J.C. Alternative splicing of Drosophila Dscam generates axon guidance receptors that exhibit isoform-specific homophilic binding. Cell 2004, 118:619-633.
23. Wojtowicz W.M., Wu W., Andre I., Qian B., Baker D., Zipursky S.L. A vast repertoire of Dscam binding specificities arises from modular interactions of variable Ig domains. Cell 2007, 130:1134-1145.
24. Zhan X.L., Clemens J.C., Neves G., Hattori D., Flanagan J.J., Hummel T., Vasconcelos M.L., Chess A., Zipursky S.L. Analysis of Dscam diversity in regulating axon guidance in Drosophila mushroom bodies. Neuron 2004, 43:673-686.
25. Zhu H., Hummel T., Clemens J.C., Berdnik D., Zipursky S.L., Luo L. Dendritic patterning by Dscam and synaptic partner matching in the Drosophila antennal lobe. Nat. Neurosci. 2006, 9:349-355.
26. Zipursky S.L., Sanes J.R. Chemoaffinity revisited: dscams, protocadherins, and neural circuit assembly. Cell 2010, 143:343-353.