Dramatic Improvement in Sexual Function Induced by Intranasal Oxytocin

Journal of Sexual Medicine

Volumn 9, Issue 5, 2012, Pages 1407-1410

  MacDonald, Kai ^a   Feifel, David ^a  

^a UCSD MEDICAL CENTER   (United States)

Author keywords

Adult; Brain physiology; Humans; Intranasal; Libido drug effects; Male; Oxytocin administration and dosage; Sexual behavior physiology

Indexed keywords

BENZODIAZEPINE; LISDEXAMFETAMINE; OXYTOCIN; SERTRALINE; TADALAFIL;

ADULT; ARTICLE; ATTENTION DEFICIT DISORDER; CASE REPORT; DRUG EFFECT; HUMAN; LIBIDO; MALE; ORGASM; PENIS ERECTION; PRIORITY JOURNAL; SEXUAL FUNCTION; SOCIAL AVOIDANCE BEHAVIOR; SOCIAL INTERACTION; SOCIAL PHOBIA; TREATMENT RESPONSE;

EID: 84860282536     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2012.02703.x     Document Type: Article

References (20)

1. Striepens N, Kendrick KM, Maier W, Hurlemann R. Prosocial effects of oxytocin and clinical evidence for its therapeutic potential. Front Neuroendocrinol 2011;32:426-50.
2. Woodbury-Smith MR, Robinson J, Wheelwright S, Baron-Cohen S. Screening adults for Asperger Syndrome using the AQ: A preliminary study of its diagnostic validity in clinical practice. J Autism Dev Disord 2005;35:331-5.
3. Andari E, Duhamel JR, Zalla T, Herbrecht E, Leboyer M, Sirigu A. Promoting social behavior with oxytocin in high-functioning autism spectrum disorders. Proc Natl Acad Sci U S A [Research Support, Non-U.S. Gov't]. 2010;107:4389-94.
4. Luminet O, Grynberg D, Ruzette N, Mikolajczak M. Personality-dependent effects of oxytocin: Greater social benefits for high alexithymia scorers. Biol Psychol 2011;87:401-6.
5. Ohlsson B, Truedsson M, Bengtsson M, Torstenson R, Sjolund K, Bjornsson ES, Simren M. Effects of long-term treatment with oxytocin in chronic constipation; a double blind, placebo-controlled pilot trial. Neurogastroenterol Motil 2005;17:697-704.
6. Feifel D, Macdonald K, Nguyen A, Cobb P, Warlan H, Galangue B, Minassian A, Becker O, Cooper J, Perry W, Lefebvre M, Gonzales J, Hadley A. Adjunctive intranasal oxytocin reduces symptoms in schizophrenia patients. Biol Psychiatry 2010;68:678-80.
7. Pedersen CA, Gibson CM, Rau SW, Salimi K, Smedley KL, Casey RL, Leserman J, Jarskog LF, Penn DL. Intranasal oxytocin reduces psychotic symptoms and improves Theory of Mind and social perception in schizophrenia. Schizophr Res 2011;132:50-3.
8. Lidberg L, Sternthal V. A new approach to the hormonal treatment of impotentia erectionis. Pharmakopsychiatr Neuropsychopharmakol 1977;10:21-5.
9. Carmichael MS, Humbert R, Dixen J, Palmisano G, Greenleaf W, Davidson JM. Plasma oxytocin increases in the human sexual response. J Clin Endocrinol Metab 1987;64:27-31.
10. Burri A, Heinrichs M, Schedlowski M, Kruger TH. The acute effects of intranasal oxytocin administration on endocrine and sexual function in males. Psychoneuroendocrinology 2008;33:591-600.
11. Anderson-Hunt M, Dennerstein L. Increased female sexual response after oxytocin. BMJ 1994;309:929.
12. Ishak WW, Berman DS, Peters A. Male anorgasmia treated with oxytocin. J Sex Med 2008;5:1022-4.
13. Damis M, Patel Y, Simpson GM. Sildenafil in the treatment of SSRI-induced sexual dysfunction: A pilot study. Prim Care Companion J Clin Psychiatry 1999;1:184-7.
14. Melis MR, Argiolas A. Central control of penile erection: A re-visitation of the role of oxytocin and its interaction with dopamine and glutamic acid in male rats. Neurosci Biobehav Rev 2011;35:939-55.
15. Succu S, Sanna F, Argiolas A, Melis MR. Oxytocin injected into the hippocampal ventral subiculum induces penile erection in male rats by increasing glutamatergic neurotransmission in the ventral tegmental area. Neuropharmacology 2011;61:181-8.
16. Skuse DH, Gallagher L. Dopaminergic-neuropeptide interactions in the social brain. Trends Cogn Sci 2009;13:27-35.
17. Succu S, Sanna F, Cocco C, Melis T, Boi A, Ferri GL, Argiolas A, Melis MR. Oxytocin induces penile erection when injected into the ventral tegmental area of male rats: Role of nitric oxide and cyclic GMP. Eur J Neurosci 2008;28:813-21.
18. Li M, Wang T, Guo S, Rao K, Liu J, Ye Z. Expression of oxytocin receptor in diabetic rat penis. Andrologia 2011 Nov 18 [Epub ahead of print] doi: 10.1111/j.1439-0272.2011.01255.x.
19. Unkelbach C, Guastella AJ, Forgas JP. Oxytocin selectively facilitates recognition of positive sex and relationship words. Psychol Sci 2008;19:1092-4.
20. Pfaus JG. Pathways of sexual desire. J Sex Med 2009;6:1506-33.