-
1
-
-
0036239832
-
HMG-CoA reductase inhibitors and the malignant cell: The statin family of drugs as triggers of tumor-specific apoptosis
-
DOI 10.1038/sj/leu/2402476
-
Wong WW, Dimitroulakos J, Minden MD and Penn LZ: HMG-CoA reductase inhibitors and the malignant cell: the statin family of drugs as triggers of tumor-specific apoptosis. Leukemia 16: 508-519, 2002. (Pubitemid 34460459)
-
(2002)
Leukemia
, vol.16
, Issue.4
, pp. 508-519
-
-
Wong, W.W.-L.1
Dimitroulakos, J.2
Minden, M.D.3
Penn, L.Z.4
-
2
-
-
17744394863
-
Effect of pravastatin on survival in patients with advanced hepatocellular carcinoma. A randomized controlled trial
-
DOI 10.1054/bjoc.2000.1716
-
Kawata S, Yamasaki E and Nagase T, et al: Effect of pravastatin on survival in patients with advanced hepatocellular carcinoma. A randomized controlled trial. Br J Cancer 84: 886-891, 2001. (Pubitemid 32385829)
-
(2001)
British Journal of Cancer
, vol.84
, Issue.7
, pp. 886-891
-
-
Kawata, S.1
Yamasaki, E.2
Nagase, T.3
Inui, Y.4
Ito, N.5
Matsuda, Y.6
Inada, M.7
Tamura, S.8
Noda, S.9
Imai, Y.10
Matsuzawa, Y.11
-
3
-
-
38349030679
-
Statins in tumor suppression
-
Sassano A and Platanias LC: Statins in tumor suppression. Cancer Lett 260: 11-19, 2008.
-
(2008)
Cancer Lett
, vol.260
, pp. 11-19
-
-
Sassano, A.1
Platanias, L.C.2
-
4
-
-
1542720382
-
Orlistat Is a Novel Inhibitor of Fatty Acid Synthase with Antitumor Activity
-
DOI 10.1158/0008-5472.CAN-03-3645
-
Kridel SJ, Axelrod F, Rozenkrantz N and Smith JW: Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity. Cancer Res 64: 2070-2075, 2004. (Pubitemid 38339455)
-
(2004)
Cancer Research
, vol.64
, Issue.6
, pp. 2070-2075
-
-
Kridel, S.J.1
Axelrod, F.2
Rozenkrantz, N.3
Smith, J.W.4
-
5
-
-
0029949512
-
Inhibition of fatty acid synthesis induces programmed cell death in human breast cancer cells
-
Pizer ES, Jackisch C, Wood FD, Pasternack GR, Davidson NE and Kuhajda FP: Inhibition of fatty acid synthesis induces programmed cell death in human breast cancer cells. Cancer Res 56: 2745-2747, 1996. (Pubitemid 26175731)
-
(1996)
Cancer Research
, vol.56
, Issue.12
, pp. 2745-2747
-
-
Pizer, E.S.1
Jackisch, C.2
Wood, F.D.3
Pasternack, G.R.4
Davidson, N.E.5
Kuhajda, F.P.6
-
6
-
-
23044480300
-
Antitumoral actions of the anti-obesity drug orlistat (Xenical™) in breast cancer cells: Blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erbB-2) oncogene
-
DOI 10.1093/annonc/mdi239
-
Menendez JA, Vellon L and Lupu R: Antitumoral actions of the anti-obesity drug orlistat (Xenical™) in breast cancer cells: blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erb B-2) oncogene. Ann Oncol 16: 1253-1267, 2005. (Pubitemid 41166507)
-
(2005)
Annals of Oncology
, vol.16
, Issue.8
, pp. 1253-1267
-
-
Menendez, J.A.1
Vellon, L.2
Lupu, R.3
-
7
-
-
3142713030
-
A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2
-
DOI 10.1074/jbc.M405061200
-
Knowles LM, Axelrod F, Browne CD and Smith JW: A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2. J Biol Chem 279: 30540-30545, 2004. (Pubitemid 38937985)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.29
, pp. 30540-30545
-
-
Knowles, L.M.1
Axelrod, F.2
Browne, C.D.3
Smith, J.W.4
-
8
-
-
0035216008
-
TRAIL/Apo-2L: Mechanisms and clinical applications in cancer
-
Srivastava RK: TRAIL/Apo-2L: mechanisms and clinical applications in cancer. Neoplasia 3: 535-546, 2001.
-
(2001)
Neoplasia
, vol.3
, pp. 535-546
-
-
Srivastava, R.K.1
-
9
-
-
0032929520
-
Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo
-
DOI 10.1038/5517
-
Walczak H, Miller RE and Ariail K, et al: Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nat Med 5: 157-163, 1999. (Pubitemid 29068521)
-
(1999)
Nature Medicine
, vol.5
, Issue.2
, pp. 157-163
-
-
Walczak, H.1
Miller, R.E.2
Ariail, K.3
Gliniak, B.4
Griffith, T.S.5
Kubin, M.6
Chin, W.7
Jones, J.8
Woodward, A.9
Le, T.10
Smith, C.11
Smolak, P.12
Goodwin, R.G.13
Rauch, C.T.14
Schuh, J.C.L.15
Lynch, D.H.16
-
10
-
-
0037148518
-
Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development
-
DOI 10.1084/jem.20011171
-
Takeda K, Smyth MJ, Cretney E, Hayakawa Y, Kayagaki N, Yagita H and Okumura K: Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development. J Exp Med 2: 161-169, 2002. (Pubitemid 34461260)
-
(2002)
Journal of Experimental Medicine
, vol.195
, Issue.2
, pp. 161-169
-
-
Takeda, K.1
Smyth, M.J.2
Cretney, E.3
Hayakawa, Y.4
Kayagaki, N.5
Yagita, H.6
Okumura, K.7
-
11
-
-
17944376030
-
Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity
-
DOI 10.1038/91000
-
Ichikawa K, Liu W and Zhao L, et al: Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity. Nat Med 7: 954-960, 2001. (Pubitemid 32756434)
-
(2001)
Nature Medicine
, vol.7
, Issue.8
, pp. 954-960
-
-
Ichikawa, K.1
Liu, W.2
Zhao, L.3
Wang, Z.4
Liu, D.5
Ohtsuka, T.6
Zhang, H.7
Mountz, J.D.8
Koopman, W.J.9
Kimberly, R.P.10
Zhou, T.11
-
12
-
-
0037672290
-
Expression of TRAIL (TNF-related apoptosis-inducing ligand) and its receptors in normal colonic mucosa, adenomas, and carcinomas
-
DOI 10.1002/path.1364
-
Koornstra JJ, Kleibeuker JH and van Geelen CM, Rijcken FE, Hollema H, de Vries EG and de Jong S: Expression of TRAIL (TNF-related apoptosis-inducing ligand) and its receptors in normal colonic mucosa, adenomas, and carcinomas. J Pathol 200: 327-335, 2003. (Pubitemid 36827307)
-
(2003)
Journal of Pathology
, vol.200
, Issue.3
, pp. 327-335
-
-
Koornstra, J.J.1
Kleibeuker, J.H.2
Van Geelen, C.M.M.3
Rijcken, F.E.M.4
Hollema, H.5
De Vries, E.G.E.6
De Jong, S.7
-
13
-
-
14644437742
-
Mechanisms of resistance to TRAIL-induced apoptosis in cancer
-
DOI 10.1038/sj.cgt.7700792
-
Zhang L and Fang B: Mechanisms of resistance to TRAIL induced apoptosis in cancer. Cancer Gene Ther 12: 228-237, 2005. (Pubitemid 40315182)
-
(2005)
Cancer Gene Therapy
, vol.12
, Issue.3
, pp. 228-237
-
-
Zhang, L.1
Fang, B.2
-
14
-
-
34748858784
-
Oxidative stress and apoptosis: Impact on cancer therapy
-
Ozben T: Oxidative stress and apoptosis: impact on cancer therapy. J Pharm Sci 96: 2181-2196, 2007.
-
(2007)
J Pharm Sci
, vol.96
, pp. 2181-2196
-
-
Ozben, T.1
-
15
-
-
2942593991
-
ROS stress in cancer cells and therapeutic implications
-
DOI 10.1016/j.drup.2004.01.004
-
Pelicano H, Carney D and Huang P: ROS stress in cancer cells and therapeutic implications. Drug Resist Updat 7: 97-110, 2004. (Pubitemid 38736063)
-
(2004)
Drug Resistance Updates
, vol.7
, Issue.2
, pp. 97-110
-
-
Pelicano, H.1
Carney, D.2
Huang, P.3
-
16
-
-
0033230607
-
Role of redox potential and reactive oxygen species in stress signaling
-
Adler V, Yin Z, Tew KD and Ronai Z: Role of redox potential and reactive oxygen species in stress signaling. Oncogene 18: 6104-6111, 1999.
-
(1999)
Oncogene
, vol.18
, pp. 6104-6111
-
-
Adler, V.1
Yin, Z.2
Tew, K.D.3
Ronai, Z.4
-
17
-
-
0035798180
-
Promoter structure and transcription initiation sites of the human death receptor 5/TRAIL-R2 gene
-
DOI 10.1016/S0014-5793(01)02947-7, PII S0014579301029477
-
Yoshida T, Maeda A, Tani N and Sakai T: Promoter structure and transcription initiation sites of the human death receptor 5/TRAIL-R2 gene. FEBS Lett 507: 381-385, 2001. (Pubitemid 33030270)
-
(2001)
FEBS Letters
, vol.507
, Issue.3
, pp. 381-385
-
-
Yoshida, T.1
Maeda, A.2
Tani, N.3
Sakai, T.4
-
18
-
-
55349089182
-
Baicalein overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance via two different cell-specific pathways in cancer cells but not in normal cells
-
Taniguchi H, Yoshida T and Horinaka M, et al: Baicalein overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance via two different cell-specific pathways in cancer cells but not in normal cells. Cancer Res 68: 8918-8927, 2008.
-
(2008)
Cancer Res
, vol.68
, pp. 8918-8927
-
-
Taniguchi, H.1
Yoshida, T.2
Horinaka, M.3
-
20
-
-
27944442079
-
Luteolin induces apoptosis via death receptor 5 upregulation in human malignant tumor cells
-
DOI 10.1038/sj.onc.1208874, PII 1208874
-
Horinaka M, Yoshida T and Shiraishi T, et al: Luteolin induces apoptosis via death receptor 5 upregulation in human malignant tumor cells. Oncogene 24: 7180-7189, 2005. (Pubitemid 41679280)
-
(2005)
Oncogene
, vol.24
, Issue.48
, pp. 7180-7189
-
-
Horinaka, M.1
Yoshida, T.2
Shiraishi, T.3
Nakata, S.4
Wakada, M.5
Nakanishi, R.6
Nishino, H.7
Matsui, H.8
Sakai, T.9
-
21
-
-
57749107578
-
Anti-gout agent allopurinol exerts cytotoxicity to human hormone-refractory prostate cancer cells in combination with tumor necrosis factor-related apoptosis-inducing ligand
-
Yasuda T, Yoshida T and Goda AE, et al: Anti-gout agent allopurinol exerts cytotoxicity to human hormone-refractory prostate cancer cells in combination with tumor necrosis factor-related apoptosis-inducing ligand. Mol Cancer Res 6: 1852-1860, 2008.
-
(2008)
Mol Cancer Res
, vol.6
, pp. 1852-1860
-
-
Yasuda, T.1
Yoshida, T.2
Goda, A.E.3
-
22
-
-
8544283103
-
CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells
-
DOI 10.1074/jbc.M406933200
-
Yamaguchi H and Wang HG: CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells. J Biol Chem 279: 45495-45502, 2004. (Pubitemid 39491535)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.44
, pp. 45495-45502
-
-
Yamaguchi, H.1
Wang, H.-G.2
-
23
-
-
0034194137
-
Tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in androgen-independent prostate cancer cells
-
Yu R, Mandlekar S, Ruben S, Ni J and Kong AN: Tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in androgen-independent prostate cancer cells. Cancer Res 60: 2384-2389, 2000. (Pubitemid 30262427)
-
(2000)
Cancer Research
, vol.60
, Issue.9
, pp. 2384-2389
-
-
Yu, R.1
Mandlekar, S.2
Ruben, S.3
Ni, J.4
Kong, A.-N.T.5
-
24
-
-
77953232360
-
Effects of androgen ablation therapy in TRAIL death ligand and its receptors expression in advanced prostate cancer
-
Koksal IT, Sanlioglu AD, Kutlu O and Sanlioglu S: Effects of androgen ablation therapy in TRAIL death ligand and its receptors expression in advanced prostate cancer. Urol Int 84: 445-451, 2010.
-
(2010)
Urol Int
, vol.84
, pp. 445-451
-
-
Koksal, I.T.1
Sanlioglu, A.D.2
Kutlu, O.3
Sanlioglu, S.4
-
25
-
-
20744456317
-
The combination of TRAIL and luteolin enhances apoptosis in human cervical cancer HeLa cells
-
DOI 10.1016/j.bbrc.2005.05.179, PII S0006291X05012015
-
Horinaka M, Yoshida T and Shiraishi T, et al: The combination of TRAIL and luteolin enhances apoptosis in human cervical cancer HeLa cells. Biochem Biophys Res Commun 333: 833-838, 2005. (Pubitemid 40854234)
-
(2005)
Biochemical and Biophysical Research Communications
, vol.333
, Issue.3
, pp. 833-838
-
-
Horinaka, M.1
Yoshida, T.2
Shiraishi, T.3
Nakata, S.4
Wakada, M.5
Nakanishi, R.6
Nishino, H.7
Sakai, T.8
-
26
-
-
4344666663
-
Histone deacetylase inhibitors upregulate death receptor 5/TRAIL-R2 and sensitize apoptosis induced by TRAIL/APO2-L in human malignant tumor cells
-
DOI 10.1038/sj.onc.1207830
-
Nakata S, Yoshida T, Horinaka M, Shiraishi T, Wakada M and Sakai T: Histone deacetylase inhibitors upregulate death receptor 5/TRAIL-R2 and sensitize apoptosis induced by TRAIL/APO2-L in human malignant tumor cells. Oncogene 23: 6261-6271, 2004. (Pubitemid 39215296)
-
(2004)
Oncogene
, vol.23
, Issue.37
, pp. 6261-6271
-
-
Nakata, S.1
Yoshida, T.2
Horinaka, M.3
Shiraishi, T.4
Wakada, M.5
Sakai, T.6
-
27
-
-
33746138649
-
Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes
-
DOI 10.1158/0008-5472.CAN-06-0169
-
Carracedo A, Gironella M and Lorente M, Garcia S, Guzman M, Velasco G and Iovanna JL: Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes. Cancer Res 66: 6748-6755, 2006. (Pubitemid 44085633)
-
(2006)
Cancer Research
, vol.66
, Issue.13
, pp. 6748-6755
-
-
Carracedo, A.1
Gironella, M.2
Lorente, M.3
Garcia, S.4
Guzman, M.5
Velasco, G.6
Iovanna, J.L.7
-
28
-
-
75149176725
-
Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways
-
Senkal CE, Ponnusamy S, Bielawski J, Hannun YA and Ogretmen B: Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways. FASEB J 24: 296-308, 2010.
-
(2010)
FASEB J
, vol.24
, pp. 296-308
-
-
Senkal, C.E.1
Ponnusamy, S.2
Bielawski, J.3
Hannun, Y.A.4
Ogretmen, B.5
-
29
-
-
79957605136
-
Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity
-
Fu S, Yang L and Li P, et al: Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity. Nature 473: 528-531, 2011.
-
(2011)
Nature
, vol.473
, pp. 528-531
-
-
Fu, S.1
Yang, L.2
Li, P.3
-
30
-
-
41149169845
-
Involvement of selective reactive oxygen species upstream of proapoptotic branches of unfolded protein response
-
Yokouchi M, Hiramatsu N and Hayakawa K, et al: Involvement of selective reactive oxygen species upstream of proapoptotic branches of unfolded protein response. J Biol Chem 283: 4252-4260, 2008.
-
(2008)
J Biol Chem
, vol.283
, pp. 4252-4260
-
-
Yokouchi, M.1
Hiramatsu, N.2
Hayakawa, K.3
-
31
-
-
7644242953
-
Proteasome inhibitor PS-341 induces apoptosis through induction of endoplasmic reticulum stress-reactive oxygen species in head and neck squamous cell carcinoma cells
-
DOI 10.1128/MCB.24.22.9695-9704.2004
-
Fribley A, Zeng Q and Wang CY: Proteasome inhibitor PS-341 induces apoptosis through induction of endoplasmic reticulum stress-reactive oxygen species in head and neck squamous cell carcinoma cells. Mol Cell Biol 24: 9695-9704, 2004. (Pubitemid 39458799)
-
(2004)
Molecular and Cellular Biology
, vol.24
, Issue.22
, pp. 9695-9704
-
-
Fribley, A.1
Zeng, Q.2
Wang, C.-Y.3
-
32
-
-
26644450729
-
Tumor necrosis factor alpha (TNFα) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNFα
-
DOI 10.1074/jbc.M505818200
-
Xue X, Piao JH and Nakajima A, et al: Tumor necrosis factor alpha (TNFα) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNFα. J Biol Chem 280: 33917-33925, 2005. (Pubitemid 41443111)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.40
, pp. 33917-33925
-
-
Xue, X.1
Piao, J.-H.2
Nakajima, A.3
Sakon-Komazawa, S.4
Kojima, Y.5
Mori, K.6
Yagita, H.7
Okumura, K.8
Harding, H.9
Nakano, H.10
-
33
-
-
55749086991
-
2 up-regulates death receptor 5 gene expression in HCT116 cells: Involvement of reactive oxygen species and C/EBP homologous transcription factor gene transcription
-
2 up-regulates death receptor 5 gene expression in HCT116 cells: involvement of reactive oxygen species and C/EBP homologous transcription factor gene transcription. Mol Cancer Ther 7: 3429-3440, 2008.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 3429-3440
-
-
Su, R.Y.1
Chi, K.H.2
Huang, D.Y.3
Tai, M.H.4
Lin, W.W.5
-
34
-
-
67349228750
-
Withaferin A sensitizes TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of death receptor 5 and down-regulation of c-FLIP
-
Lee TJ, Um HJ, Min DS, Park JW, Choi KS and Kwon TK: Withaferin A sensitizes TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of death receptor 5 and down-regulation of c-FLIP. Free Radic Biol Med 46: 1639-1649, 2009.
-
(2009)
Free Radic Biol Med
, vol.46
, pp. 1639-1649
-
-
Lee, T.J.1
Um, H.J.2
Min, D.S.3
Park, J.W.4
Choi, K.S.5
Kwon, T.K.6
-
35
-
-
77951215549
-
Celastrol, a triterpene, enhances TRAIL-induced apoptosis through the down-regulation of cell survaival proteins and up-regulation of death receptors
-
Sung B, Park B, Yadav VR and Aggarwal BB: Celastrol, a triterpene, enhances TRAIL-induced apoptosis through the down-regulation of cell survaival proteins and up-regulation of death receptors. J Biol Chem 285: 11498-11507, 2010.
-
(2010)
J Biol Chem
, vol.285
, pp. 11498-11507
-
-
Sung, B.1
Park, B.2
Yadav, V.R.3
Aggarwal, B.B.4
-
36
-
-
78149256773
-
Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL
-
Sung B, Ravindran J, Prasad S, Pandey MK and Aggarwal BB: Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL. J Biol Chem 285: 35418-35427, 2010.
-
(2010)
J Biol Chem
, vol.285
, pp. 35418-35427
-
-
Sung, B.1
Ravindran, J.2
Prasad, S.3
Pandey, M.K.4
Aggarwal, B.B.5
-
37
-
-
78751522712
-
ROS and CHOP are critical for dibenxylideneacetone to sensitize tumor cells to TRAIL through induction of death receptors and downregulation of cell survival proteins
-
Prasad S, Yadav VR, Ravindran J and Aggarwal BB: ROS and CHOP are critical for dibenxylideneacetone to sensitize tumor cells to TRAIL through induction of death receptors and downregulation of cell survival proteins. Cancer Res 71: 538-549, 2011.
-
(2011)
Cancer Res
, vol.71
, pp. 538-549
-
-
Prasad, S.1
Yadav, V.R.2
Ravindran, J.3
Aggarwal, B.B.4
-
38
-
-
84860268669
-
5, 7-Dimethoxyflavone sensitizes TRAIL-induced apoptosis through DR5 upregulation in hepatocellular carcinoma cells
-
Jun 10, Epub ahead of print
-
Yang JF, Cao JG, Tian L and Liu F: 5, 7-Dimethoxyflavone sensitizes TRAIL-induced apoptosis through DR5 upregulation in hepatocellular carcinoma cells. Cancer Chemother Pharmacol: Jun 10, 2011 (Epub ahead of print).
-
(2011)
Cancer Chemother Pharmacol
-
-
Yang, J.F.1
Cao, J.G.2
Tian, L.3
Liu, F.4
-
39
-
-
84855698586
-
Cardomonin sensitizes tumor cells to TRAIL through ROS- And CHOP-mediated upregulation of death receptors and downregulation of survival proteins
-
Jul 28, (Epub ahead of print). doi: 10.1111/j.1476-5381.2011.01603.x
-
Yadav VR, Prasad S and Aggrwal BB: Cardomonin sensitizes tumor cells to TRAIL through ROS- and CHOP-mediated upregulation of death receptors and downregulation of survival proteins. Br J Pharmacol: Jul 28, 2011 (Epub ahead of print). doi: 10.1111/j.1476-5381.2011.01603.x.
-
(2011)
Br J Pharmacol
-
-
Yadav, V.R.1
Prasad, S.2
Aggrwal, B.B.3
|