The expressions and correlation of bcl-2 and beclin-1 in pancreatic cancer

Journal of Sichuan University (Medical Science)

Volumn 43, Issue 2, 2012, Pages 156-160

  Cao, Shuang Shuang ^a   Su, An Ping ^a   Du, Xiao Jiong ^a   Li, Ang ^a   Huw, Ei Ming ^a   Zhang, Zhao Da ^a   Tian, Bo Le ^a   Lu, Hui Min ^a   Ke, Neng Wen ^a   He, Zhaopeng ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Apoptosis; Autophagy; Bcl 2; Beclin 1; Pancreatic cancer

Indexed keywords

EID: 84860249699     PISSN: 1672173X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Hermanovu M, Nenutil R, Kren L, et al. Proliferative activity in pancreatic intraepithelial neoplasias of chronic pancreatitis resection specimens, detection of a high-risk lesion. Neoplasma, 2004,51 ( 5 ) : 400-404. (Pubitemid 39486116)
2. Otsuki M, Tashiro M. Chronic pancreatitis and pancreatic cancer, lifestyle-related diseases. Intern Med, 2007, 46 (2): 109-113. (Pubitemid 46157701)
3. Jeurnink SM, Vleggaar FP, Siersema PD. Overview of the clinical problem, facts and current issues of mucinous cystic neoplasms of the pancreas. Dig Liver Dis, 2008, 40 ( 11 ):837-846.
4. Clarke PG. Developmental cell death:morphological diversity and multiple mechanisms. Anat Embryol, 1990,181 (3):195-213. (Pubitemid 20153523)
5. Vaux DL, Cory S, Adams JM. Bcl-2 gene promotes haemopoietic cell survival and cooporates with c-myc to immortalize pre-B cell. Nature, 1988,335(6189):440-442.
6. Liang XH, Jackson S, Seaman M, et al. Induction of autophagy and inhibition of tumorigenesis by bectin 1. Nature, 1999, 402(6762) : 672-676. (Pubitemid 129516338)
7. Sun CY, Wang BL, Hu CQ, etal. Expression of the bcl2 gene and its significance in human pancreatic carcinoma. Hepatobiliary Pancreat Dis Int,2002,1(2):306-308.
8. Campani D, Esposito I, Boggi U, et al. Bcl-2 expression in pancreas development and pancreatic cancer progression. J Pathol,2001,194(4):444-450. (Pubitemid 32782669)
9. Friess H, Lu Z, Graber HU, et al. Bax, but not bcl-2, influences the prognosis of human pancreatic cancer. Gut, 1998,43(3):414-421. (Pubitemid 28414925)
10. Tóth S, Nagy K, Pálfia Z, et al. Cellular autophagic capacity changes during azaserine-induced tumour progression in the rat pancreas. Up-regulation in all premalignant stages and downregulation with loss of cycloheximide sensitivity of segregation along with malignant transformation. Cell Tissue Res, 2002, 309(3):409-416.
11. Boya P, Gonzalez-Polo RA, Casares N, et al. Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol, 2005, 25 (3) : 1025-1040. (Pubitemid 40165810)
12. Aita VM, Liang XH, Murty VV, et al. Cloning and genomic organ ization of beclinl, a candidate tumor suppressor gene on chromosome 17q21. Genomic,1999,59(1):59-65. (Pubitemid 29339873)
13. Yue Z, Jin S, Yang C, et al. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci USA, 2003,100(25) : 15077-15082. (Pubitemid 37518019)
14. Mtracco C, Cevenini G, Franchi A, et al. Beclinl and LC3 autophagic gene expression in cutaneous melanocytic lesions. Hum Pathol, 2010, 41(4):503-512.
15. Oberstein A, Jeffrey PD, Shi Y. Crystal structure of the Bcl-XL-Beclinl peptide complex, Beclin 1 is a novel BH3-only protein. J Biol Chem,2007,282(17):13123-13132. (Pubitemid 47100641)
16. Pattingre S, Tassa A, Qu X, et al. Bcl-2 antiapoptotic proteins inhibit Beclinl-dependent autophagy. Cell, 2005, 122 (6),927-939. (Pubitemid 41345209)
17. Maiuri MC, Criollo A, Tasdemir E, et al. BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between beclin 1 and Bcl-2/Bcl-X (L). Autophagy,2007,3(4):374-376.
18. Wei Y, Pattingre S, Sinha S, et al. JNK 1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol Cell, 2008,30( 6):678-688. (Pubitemid 351818252)
19. Won KY, Kim GY, Kim YW, et al. Clinicopathologic correlation of beclin-1 and bcl-2 expression in human breast cancer. Hum Pathol,2010,41(1):107-112.