Do inhaled corticosteroid/long-acting beta 2-agonist fixed combinations provide superior clinical benefits compared with separate inhalers? A literature reappraisal

Allergy and Asthma Proceedings

Volumn 33, Issue 2, 2012, Pages 140-144

  Barnes, Peter J ^a   Nicolini, Gabriele ^b   Bizzi, Andrea ^b   Spinola, Monica ^b   Singh, Dave ^c  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b CHIESI FARMACEUTICI S P A   (Italy)

^c MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BECLOMETASONE; BUDESONIDE PLUS FORMOTEROL; FLUTICASONE PROPIONATE PLUS FORMOTEROL FUMARATE; FLUTICASONE PROPIONATE PLUS SALMETEROL; FORMOTEROL;

AEROSOL; ARTICLE; ASTHMA; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG FORMULATION; HUMAN; INHALER; INTERMETHOD COMPARISON;

ADMINISTRATION, INHALATION; ADRENAL CORTEX HORMONES; ADRENERGIC BETA-2 RECEPTOR AGONISTS; ANTI-ASTHMATIC AGENTS; ANTI-INFLAMMATORY AGENTS; ASTHMA; BECLOMETHASONE; DRUG COMBINATIONS; DRUG THERAPY, COMBINATION; ETHANOLAMINES; HUMANS; IMMUNOSUPPRESSIVE AGENTS; NEBULIZERS AND VAPORIZERS; PARTICLE SIZE; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 84860231453     PISSN: 10885412     EISSN: 15396304     Source Type: Journal    
DOI: 10.2500/aap.2012.33.3512     Document Type: Article

References (28)

1. Takeda T, Oga T, Niimi A, Relationship between small airway function and health status, dyspnea, and disease control in asthma. Respiration 80:120-126, 2010.
2. Greening AP, Ind PW, Northfield M, and Shaw G. Added salmeterol versus higher-dose corticosteroid in asthma patients with symptoms on existing inhaled corticosteroid. Allen & Hanburys Limited UK Study Group. Lancet 344:219-224, 1994. (Pubitemid 24229008)
3. Woolcock A, Lundback B, Ringdal N, and Jacques LA. Comparison of addition of salmeterol to inhaled steroids with doubling of the dose of inhaled steroids. Am J Respir Crit Care Med 153:1481-1488, 1996. (Pubitemid 26141329)
4. Matz J, Emmett A, Rickard K, and Kalberg C. Addition of salmeterol to low-dose fluticasone versus higher-dose fluticasone: An analysis of asthma exacerbations. J Allergy Clin Immunol 107:783-789, 2001. (Pubitemid 32436910)
5. Shrewsbury S, Pyke S, and Britton M. Meta-analysis of increased dose of inhaled steroid or addition of salmeterol in symptomatic asthma (MIASMA). BMJ 320:1368-1373, 2000. (Pubitemid 30261116)
6. Pauwels RA, Löfdahl CG, Postma DS, et al. Effect of inhaled formoterol and budesonide on exacerbations of asthma. Formoterol and Corticosteroids Establishing Therapy (FACET) International Study Group. N Engl J Med 337:1405-1411, 1997.
7. Barnes PJ. Scientific rationale for using a single inhaler for asthma control. Eur Respir J 29:587-595, 2007. (Pubitemid 46372109)
8. Juniper EF, O'Byrne PM, Guyatt GH, et al. Development and validation of a questionnaire to measure asthma control. Eur Respir J 14:902-907, 1999. (Pubitemid 29519356)
9. Huchon G, Magnussen H, Chuchalin A, et al. Lung function and asthma control with beclomethasone and formoterol in a single inhaler. Respir Med 103:41-49, 2009.
10. Bateman ED, Britton M, Carrillo J, et al. Salmeterol/fluticasone combination inhaler: A new, effective and well tolerated treatment for asthma. Clin Drug Investig 16:193-201, 1998. (Pubitemid 28477069)
11. Chapman KR, Ringdal N, Backer V, et al. Salmeterol and fluticasone propionate (50/250 microg) administered via combination Diskus inhaler: As effective as when given via separate Diskus inhalers. Can Respir J 6:45-51, 1999. (Pubitemid 29158748)
12. Aubier M, Pieters WR, Schlö sser NJ, and Steinmetz KO. Salmeterol/fluticasone propionate (50/500 microg) in combination in a Diskus inhaler (Seretide) is effective and safe in the treatment of steroid-dependent asthma. Respir Med 93:876-884, 1999. (Pubitemid 30042638)
13. Zetterström O, Buhl R, Mellem H, et al. Improved asthma control with budesonide/formoterol in a single inhaler, compared with budesonide alone. Eur Respir J 18:262-268, 2001. (Pubitemid 32776399)
14. Rosenhall L, Heinig JH, Lindqvist A, et al. Budesonide/formoterol (Symbicort) is well tolerated and effective in patients with moderate persistent asthma. Int J Clin Pract 56:427-433, 2002. (Pubitemid 34855301)
15. Rosenhall L, Elvstrand A, Tilling B, et al. One-year safety and efficacy of budesonide/formoterol in a single inhaler (Symbicort Turbuhaler) for the treatment of asthma. Respir Med 97:702-708, 2003. (Pubitemid 36675675)
16. Jenkins C, Kolarikova R, Kuna P, et al. Efficacy and safety of high-dose budesonide/formoterol (Symbicort) compared with budesonide administered either concomitantly with formoterol or alone in patients with persistent symptomatic asthma. Respirology 11:276-286, 2006.
17. Chervinsky P, Baker J, Bensch G, et al. Patient-reported outcomes in adults with moderate to severe asthma after use of budesonide and formoterol administered via 1 pressurized metered-dose inhaler. Ann Allergy Asthma Immunol 101:463-473, 2008.
18. Bodzenta-Lukaszyk A, Pulka G, Dymek A, et al. Efficacy and safety of fluticasone and formoterol in a single pressurized metered dose inhaler. Respir Med 105:674-682, 2011.
19. Chowdhury BA, and Dal Pan G. The FDA and safe use of long-acting beta-agonists in the treatment of asthma. N Engl J Med 362:1169-1171, 2010.
20. Nelson HS, Chapman KR, Pyke SD, et al. Enhanced synergy between fluticasone propionate and salmeterol inhaled from a single inhaler versus separate inhalers. J Allergy Clin Immunol 112:29-36, 2003. (Pubitemid 36819803)
21. Nicolini G, Scichilone N, Bizzi A, et al. Beclomethasone/formoterol fixed combination for the management of asthma: Patient considerations. Ther Clin Risk Manag 4:855-864, 2008.
22. Fabbri LM, Nicolini G, Olivieri D, and Papi A. Inhaled beclometasone dipropionate/formoterol extra-fine fixed combination in the treatment of asthma: Evidence and future perspectives. Expert Opin Pharmacother 9:479-490, 2008. (Pubitemid 351291792)
23. De Backer W, Devolder A, Poli G, et al. Lung deposition of BDP/formoterol HFA pMDI in healthy volunteers, asthmatic, and COPD patients. J Aerosol Med Pulm Drug Deliv 23:137-148, 2010.
24. Weinstein SF, Corren J, Murphy K, et al., and Study Investigators of P04431. Twelve-week efficacy and safety study of mometasone furoate/formoterol 200/10 microg and 400/10 microg combination treatments in patients with persistent asthma previously receiving high-dose inhaled corticosteroids. Allergy Asthma Proc 31:280-289, 2010.
25. Nathan RA, Nolte H, and Pearlman DS, and P04334 Study Investigators. Twenty-six-week efficacy and safety study of mometasone furoate/formoterol 200/10 microg combination treatment in patients with persistent asthma previously receiving medium-dose inhaled corticosteroids. Allergy Asthma Proc 31:269-279, 2010.
26. Meltzer EO, Kuna P, Nolte H, et al., on Behalf of the P04073 Study Investigators. Mometasone furoate/formoterol reduces asthma deteriorations and improves lung function. Eur Respir J 39:379-389, 2012.
27. Cohen J, Postma DS, Douma WR, et al. Particle size matters: Diagnostics and treatment of small airways involvement in asthma. Eur Respir J 37:532-540, 2011.
28. Burgel PR. The role of small airways in obstructive airway diseases. Eur Respir Rev 20:23-33, 2011.