Lipolysis in early lactation is associated with an increase in phosphorylation of adenosine monophosphate-activated protein kinase (AMPK)α1 in adipose tissue of dairy cows

Journal of Dairy Science

Volumn 95, Issue 5, 2012, Pages 2497-2504

  Locher, L F ^a   Rehage, J ^a   Khraim, N ^a   Meyer, U ^b   Danicke S ^b   Hansen, K ^a   Huber, K ^a  

^a UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

^b FEDERAL RESEARCH INSTITUTE FOR ANIMAL HEALTH   (Germany)

Author keywords

Adenosine monophosphate activated protein kinase (AMPK) 1; Dairy cow; Lipolysis; Subcutaneous and retroperitoneal adipose tissue

Indexed keywords

ACTIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE;

ADIPOSE TISSUE; ANIMAL; ANIMAL DISEASE; ARTICLE; BIOSYNTHESIS; CATTLE; DIET; ENZYMOLOGY; FEMALE; LACTATION; LIPOLYSIS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PUERPERIUM; WESTERN BLOTTING;

ACTINS; ADIPOSE TISSUE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BLOTTING, WESTERN; CATTLE; DIET; FEMALE; LACTATION; LIPOLYSIS; PHOSPHORYLATION; POSTPARTUM PERIOD;

ANIMALIA; BOVINAE;

EID: 84860230317     PISSN: 00220302     EISSN: 15253198     Source Type: Journal    
DOI: 10.3168/jds.2011-4830     Document Type: Article

References (37)

1. Akter S.H., Häussler S., Dänicke S., Müller U., von Soosten D., Rehage J., Sauerwein H. Physiological and conjugated linoleic acid-induced changes of adipocyte size in different fat depots of dairy cows during early lactation. J. Dairy Sci. 2011, 94:2871-2882.
2. Arvidsson E., Blomqvist L., Ryden M. Depot-specific differences in perilipin mRNA but not protein expression in obesity. J. Intern. Med. 2004, 255:595-601.
3. Baldwin R.L., Lin H.J., Cheng W., Cabrera R., Ronning M. Enzyme and metabolite levels in mammary and abdominal adipose tissue of lactating dairy cows. J. Dairy Sci. 1969, 52:183-187.
4. Brooks B., Arch J.R., Newsholme E.A. Effects of hormones on the rate of the triacylglycerol/fatty acid substrate cycle in adipocytes and epididymal fat pads. FEBS Lett. 1982, 146:327-330.
5. Daval M., Foufelle F., Ferre P. Functions of AMP-activated protein kinase in adipose tissue. J. Physiol. 2006, 574:55-62.
6. Fisher R.M., Eriksson P., Hoffstedt J., Hotamisligil G.S., Thorne A., Ryden M., Hamsten A., Arner P. Fatty acid binding protein expression in different adipose tissue depots from lean and obese individuals. Diabetologia 2001, 44:1268-1273.
7. Gaidhu M.P., Fediuc S., Anthony N.M., So M., Mirpourian M., Perry R.L., Ceddia R.B. Prolonged AICAR-induced AMP-kinase activation promotes energy dissipation in white adipocytes: Novel mechanisms integrating HSL and ATGL. J. Lipid Res. 2009, 50:704-715.
8. Gauthier M.S., Miyoshi H., Souza S.C., Cacicedo J.M., Saha A.K., Greenberg A.S., Ruderman N.B. AMP-activated protein kinase is activated as a consequence of lipolysis in the adipocyte: Potential mechanism and physiological relevance. J. Biol. Chem. 2008, 283:16514-16524.
9. Gauthier M.S., O'Brien E.L., Bigornia S., Mott M., Cacicedo J.M., Xu X.J., Gokce N., Apovian C., Ruderman N. Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans. Biochem. Biophys. Res. Commun. 2011, 404:382-387.
10. Empfehlungen zur Energie- und Nährstoffversorgung der Milchkühe und Aufzuchtrinder. Energie- und Nährstoffbedarf landwirtschaftlicher Nutztiere. Nr. 8 2001, GfE (Society of Nutrition Physiology), DLG-Verlag, Frankfurt am Main, Germany.
11. Hanigan M.D., Bateman H.G., Fadel J.G., McNamara J.P. Metabolic models of ruminant metabolism: Recent improvements and current status. J. Dairy Sci. 2006, 89(E. Suppl.):E52-E64.
12. Hardie D.G., Hawley S.A., Scott J.W. AMP-activated protein kinase-Development of the energy sensor concept. J. Physiol. 2006, 574:7-15.
13. Holm C. Molecular mechanisms regulating hormone-sensitive lipase and lipolysis. Biochem. Soc. Trans. 2003, 31:1120-1124.
14. Holtenius P., Holtenius K. A model to estimate insulin sensitivity in dairy cows. Acta Vet. Scand. 2007, 49:29.
15. Jaster E.H., Wegner T.N. Beta-adrenergic receptor involvement in lipolysis of dairy cattle subcutaneous adipose tissue during dry and lactating state. J. Dairy Sci. 1981, 64:1655-1663.
16. Kahn B.B., Alquier T., Carling D., Hardie D.G. AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab. 2005, 1:15-25.
17. Kindahl H., Kornmatitsuk B., Gustafsson H. The cow in endocrine focus before and after calving. Reprod. Domest. Anim. 2004, 39:217-221.
18. Kola B., Christ-Crain M., Lolli F., Arnaldi G., Giacchetti G., Boscaro M., Grossman A.B., Korbonits M. Changes in adenosine 5'-monophosphate-activated protein kinase as a mechanism of visceral obesity in Cushing's syndrome. J. Clin. Endocrinol. Metab. 2008, 93:4969-4973.
19. Kuhla B., Albrecht D., Kuhla S., Metges C.C. Proteome analysis of fatty liver in feed-deprived dairy cows reveals interaction of fuel sensing, calcium, fatty acid, and glycogen metabolism. Physiol. Genomics 2009, 37:88-98.
20. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227:680-685.
21. Lim C.T., Kola B., Korbonits M. AMPK as a mediator of hormonal signalling. J. Mol. Endocrinol. 2010, 44:87-97.
22. Locher L.F., Meyer N., Weber E.-M., Rehage J., Meyer U., Dänicke S., Huber K. Hormone-sensitive lipase protein expression and extent of phosphorylation in subcutaneous and retroperitoneal adipose tissues in the periparturient dairy cow. J. Dairy Sci. 2011, 94:4514-4523.
23. McFadden J.W., Corl B.A. Activation of AMP-activated protein kinase (AMPK) inhibits fatty acid synthesis in bovine mammary epithelial cells. Biochem. Biophys. Res. Commun. 2009, 390:388-393.
24. McNamara J.P., Becker-Khaleel B., Parmley K.L. Quantitative relationships between cyclic adenosine-3'5'-monophosphate and lipolysis in adipose tissue during the periparturient period. J. Dairy Sci. 1992, 75:1901-1913.
25. McNamara J.P., Hiller J.K. Regulation of bovine adipose tissue metabolism during lactation. 1. Lipid synthesis in response to increased milk production and decreased energy intake. J. Dairy Sci. 1986, 69:3032-3041.
26. McNamara J.P., Hillers J.K. Regulation of bovine adipose tissue metabolism during lactation. 2. Lipolysis response to milk production and energy intake. J. Dairy Sci. 1986, 69:3042-3050.
27. Omar B., Zmuda-Trzebiatowska E., Manganiello V., Goransson O., Degermann E. Regulation of AMP-activated protein kinase by cAMP in adipocytes: Roles for phosphodiesterase, protein kinase B, protein kinase A, Epac and lipolysis. Cell. Signal. 2009, 21:760-766.
28. Opstvedt J., Baldwin R.L., Ronning M. Effect of diet upon activities of several enzymes in abdominal adipose and mammary tissues in the lactating dairy cow. J. Dairy Sci. 1967, 50:108-109.
29. Rossmeisl M., Flachs P., Brauner P., Sponarova J., Matejkova O., Prazak T., Ruzickova J., Bardova K., Kuda O., Kopecky J. Role of energy charge and AMP-activated protein kinase in adipocytes in the control of body fat stores. Int. J. Obes. Relat. Metab. Disord. 2004, 28(Suppl. 4):S38-S44.
30. Ruderman N.B., Park H., Kaushik V.K., Dean D., Constant S., Prentki M., Saha A.K. AMPK as a metabolic switch in rat muscle, liver and adipose tissue after exercise. Acta Physiol. Scand. 2003, 178:435-442.
31. Smith T.R., McNamara J.P. Regulation of bovine adipose tissue metabolism during lactation. 6. Cellularity and hormone-sensitive lipase activity as affected by genetic merit and energy intake. J. Dairy Sci. 1990, 73:772-783.
32. Sponarova J., Mustard K.J., Horakova O., Flachs P., Rossmeisl M., Brauner P., Bardova K., Thomason-Hughes M., Braunerova R., Janovska P., Hardie D.G., Kopecky J. Involvement of AMP-activated protein kinase in fat depot-specific metabolic changes during starvation. FEBS Lett. 2005, 579:6105-6110.
33. Sullivan J.E., Brocklehurst K.J., Marley A.E., Carey F., Carling D., Beri R.K. Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell-permeable activator of AMP-activated protein kinase. FEBS Lett. 1994, 353:33-36.
34. Sumner J.M., McNamara J.P. Expression of lipolytic genes in the adipose tissue of pregnant and lactating Holstein dairy cattle. J. Dairy Sci. 2007, 90:5237-5246.
35. Sumner-Thomson J.M., Vierck J.L., McNamara J.P. Differential expression of genes in adipose tissue of first-lactation dairy cattle. J. Dairy Sci. 2011, 94:361-369.
36. Vernon R.G., Finley E., Watt P.W. Adenosine and the control of adrenergic regulation of adipose tissue lipolysis during lactation. J. Dairy Sci. 1991, 74:695-705.
37. Winder W.W., Hardie D.G. AMP-activated protein kinase, a metabolic master switch: Possible roles in type 2 diabetes. Am. J. Physiol. 1999, 277:E1-E10.