Thrombophylaxis and bleeding complications after cesarean section

Acta Obstetricia et Gynecologica Scandinavica

Volumn 91, Issue 5, 2012, Pages 560-565

  Snijder, Claudia A ^a   Cornette, Jerôme M W ^a   Hop, Wim C J ^a   Kruip, Marieke J H A ^a   Duvekot, Johannes J ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Bleeding complications; cesarean section; general obstetrics; low molecular weight heparins; thromboprophylaxis

Indexed keywords

DALTEPARIN; NADROPARIN;

ARTICLE; BODY MASS; CESAREAN SECTION; CROSS-SECTIONAL STUDY; FEMALE; HELLP SYNDROME; HUMAN; MAJOR CLINICAL STUDY; POSTOPERATIVE COMPLICATION; POSTOPERATIVE HEMORRHAGE; POSTOPERATIVE PERIOD; PREGNANCY COMPLICATION; PREOPERATIVE PERIOD; PRIORITY JOURNAL; PUERPERIUM; REOPERATION; RETROSPECTIVE STUDY; THROMBOCYTE COUNT; THROMBOEMBOLISM; THROMBOSIS; THROMBOSIS PREVENTION;

ADULT; CESAREAN SECTION; COHORT STUDIES; CROSS-SECTIONAL STUDIES; DALTEPARIN; DRUG THERAPY, COMBINATION; FEMALE; FIBRINOLYTIC AGENTS; HUMANS; INCIDENCE; NADROPARIN; POSTOPERATIVE HEMORRHAGE; PREGNANCY; RETROSPECTIVE STUDIES; THROMBOEMBOLISM;

EID: 84860226994     PISSN: 00016349     EISSN: 16000412     Source Type: Journal    
DOI: 10.1111/j.1600-0412.2012.01351.x     Document Type: Article

References (17)

1. Greer IA,. Thrombosis in pregnancy: Maternal and fetal issues. Lancet. 1999; 353: 1258-65.
2. Simpson EL, Lawrenson RA, Nightingale AL, Farmer RD,. Venous thromboembolism in pregnancy and the puerperium: Incidence and additional risk factors from a London perinatal database. Br J Obstet Gynaecol. 2001; 108: 56-60.
3. James AH, Jamison MG, Brancazio LR, Myers ER,. Venous thromboembolism during pregnancy and the postpartum period: Incidence, risk factors, and mortality. Am J Obstet Gynecol. 2006; 194: 1311-5.
4. Nelson-Piercy C., Hazards of heparin: Allergy, heparin-induced thrombocytopenia and osteoporosis. Baillieres Clin Obstet Gynaecol. 1997; 11: 489-509.
5. Ellison J, Thomson AJ, Conkie JA, McCall F, Walker D, Greer A., Thromboprophylaxis following caesarean section-a comparison of the antithrombotic properties of three low molecular weight heparins-dalteparin, enoxaparin and tinzaparin. Thromb Haemost. 2001; 86: 1374-8.
6. Fareed J, Hoppensteadt D, Schultz C, Ma Q, Kujawski MF, Neville B, et al,. Biochemical and pharmacologic heterogeneity in low molecular weight heparins. impact on the therapeutic profile. Curr Pharm Des. 2004; 10: 983-99.
7. Bates SM, Greer IA, Pabinger I, Sofaer S, Hirsh J, American College of Chest Physicians. Venous thromboembolism, thrombophilia, antithrombotic therapy, and pregnancy: American College of Chest Physicians evidence-based clinical practice guidelines (8th edn). Chest. 2008; 133: 844S-86S.
8. Royal College of Obstetricians and Gynaecologists. Thromboprophylaxis during pregnancy, labour and after vaginal delivery. 2004; Guideline No. 37. Available online at: (accessed December 2009).
9. Bloomfield T., Caesarean section, NICE guidelines and management of labour. J Obstet Gynaecol. 2004; 24: 485-90.
10. Burrows RF, Gan ET, Gallus AS, Wallace EM, Burrows EA,. A randomized double-blind placebo controlled trial of low molecular weight heparin as prophylaxis in preventing venous thrombolic events after caesarean section: A pilot study. Br J Obstet Gynaecol. 2001; 108: 835-9.
11. Gates S, Brocklehurst P, Ayers S, Bowler U, Thromboprophylaxis in Pregnancy Advisory Group. Thromboprophylaxis and pregnancy: Two randomized controlled pilot trials that used low-molecular-weight heparin. Am J Obstet Gynecol. 2004; 191: 1296-303.
12. Steegers EAP, van Dadelszen P, Duvekot JJ, Pijnenborg R., Pre-eclampsia. Lancet. 2010; 376: 631-44.
13. Royal College of Obstetricians and Gynaecologists. Report of the RCOG working party on prophylaxis against thromboembolism in gynaecology and obstetrics. London: RCOG Press, 1995.
14. Kakkar VV, Kakkar S, Sanderson RM, Peers CE,. Efficacy and safety of two regimens of low molecular weight heparin fragment (fragmin) in preventing postoperative venous thrombolism. Haemostasis. 1986; 16: 19-24.
15. van Wijk FH, Wolf H, Piek JM, Buller HR,. Administration of low molecular weight heparin within two hours before caesarean section increases the risk of wound haematoma. Br J Obstet Gynaecol. 2002; 109: 955-7.
16. Cornette J, Jacquemyn Y, Vercauteren M, Buytaert P., A randomised trial to compare the effect of pre- or postoperative nandroparin on blood loss during elective caesarean section. Phlebology. 2002; 17: 67-9.
17. Jacobsen AF, Skjeldestad FE, Sandset PM,. Incidence and risk patterns of venous thromboembolism in pregnancy and puerperium-a register-based case-control study. Am J Obstet Gynecol. 2008; 198: 233e1-7.