Parkin: Much more than a simple ubiquitin ligase

Neurodegenerative Diseases

Volumn 10, Issue 1-4, 2012, Pages 49-51

  Alves Da Costa, C ^a   Checler, F ^a  

^a INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

Mutations; p53; Parkin; Parkinson's disease; Transcription factor

Indexed keywords

MESSENGER RNA; PARKIN; PROTEIN P53; UBIQUITIN PROTEIN LIGASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN; CELL DEATH; DOWN REGULATION; GENE MUTATION; MOUSE; NERVE CELL; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROMOTER REGION;

ANIMALS; BRAIN; CELL DEATH; HUMANS; MICE; MUTATION; PARKINSON DISEASE; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN-PROTEIN LIGASES;

EID: 84860222148     PISSN: 16602854     EISSN: 16602862     Source Type: Journal    
DOI: 10.1159/000332803     Document Type: Article

References (17)

1. Agid Y, Arnulf I, Bejjani P, Bloch F, Bonnet AM, Damier P, Dubois B, Francois C, Houeto JL, Iacono D, Karachi C, Mesnage V, Messouak O, Vidailhet M, Welter ML, Yelnik J: Parkinson's disease is a neuropsychiatric disorder. Adv Neurol 2003; 91: 365-370.
2. Vidailhet M: Movement disorders in 2010: Parkinson disease-symptoms and treatments. Nat Rev Neurol 2011; 7: 70-72.
3. Caviness JN, Lue L, Adler CH, Walker DG: Parkinson's disease dementia and potential therapeutic strategies. CNS Neurosci Ther 2011; 17: 32-44.
4. Mizuno Y, Hattori N, Kubo S, Sato S, Nishioka K, Hatano T, Tomiyama H, Funayama M, Machida Y, Mochizuki H: Progress in the pathogenesis and genetics of Parkinson's disease. Philos Trans R Soc Lond B Biol Sci 2008; 363: 2215-2227.
5. Martin I, Dawson VL, Dawson TM: Recent advances in the genetics of Parkinson's disease. Annu Rev Genomics Hum Genet 2011; 12: 301-325.
6. Gasser T: Genetics of Parkinson's disease. Clin Genet 1998; 54: 259-265.
7. Lesage S, Brice A: Parkinson's disease: from monogenic forms to genetic susceptibility factors. Hum Mol Genet 2009; 18:R48-R59.
8. Martin I, Dawson VL, Dawson TM: The impact of genetic research on our understanding of Parkinson's disease. Prog Brain Res 2010; 183: 21-41.
9. Nuytemans K, Theuns J, Cruts M, Van Broeckhoven C: Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update. Hum Mutat 2010; 31: 763-780.
10. Hartmann A, Hirsch EC: Parkinson's disease. The apoptosis hypothesis revisited. Adv Neurol 2001; 86: 143-153.
11. Dawson TM, Dawson VL: The role of parkin in familial and sporadic Parkinson's disease. Mov Disord 2010; 25(suppl 1):S32-S39.
12. Jiang H, Ren Y, Zhao J, Feng J: Parkin protects human dopaminergic neuroblastoma cells against dopamine-induced apoptosis. Hum Mol Genet 2004; 13: 1745-1754.
13. Pesah Y, Pham T, Burgess H, Middlebrooks B, Verstreken P, Zhou Y, Harding M, Bellen H, Mardon G: Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress. Development 2004; 131: 2183-2194.
14. Shimura H, Hattori N, Kubo S, Mizuno Y, Asakawa S, Minoshima S, Shimizu N, Iwai K, Chiba T, Tanaka K, Suzuki T: Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. Nat Genet 2000; 25: 302-305.
15. Da Costa CA, Sunyach C, Giaime E, West A, Corti O, Brice A, Safe S, Abou-Sleiman PM, Wood NW, Takahashi H, Goldberg MS, Shen J, Checler F: Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease. Nat Cell Biol 2009; 11: 1370-1375.
16. Da Costa CA, Checler F: A novel parkin-mediated transcriptional function links p53 to familial Parkinson's disease. Cell Cycle 2010; 9: 16-17.
17. Alves da Costa C, Ancolio K, Checler F: Wild-type but not Parkinson's disease-related ala-53->Thr mutant/α / -synuclein protect neuronal cells from apoptotic stimuli. J Biol Chem 2000; 275: 24065-24069.