-
1
-
-
0024299370
-
Apolipoprotein E: Cholesterol transport protein with expanding role in cell biology
-
Mahley RW. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science. 1988;240:622-630.
-
(1988)
Science
, vol.240
, pp. 622-630
-
-
Mahley, R.W.1
-
2
-
-
0023860891
-
Apolipoprotein E polymorphism and atherosclerosis
-
Davignon J, Gregg RE, Sing CF. Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis. 1988;8:1-21. (Pubitemid 18049171)
-
(1988)
Arteriosclerosis
, vol.8
, Issue.1
, pp. 1-21
-
-
Davignon, J.1
Gregg, R.E.2
Sing, C.F.3
-
3
-
-
34548736492
-
Association of apolipoprotein e genotypes with lipid levels and coronary risk
-
DOI 10.1001/jama.298.11.1300
-
Bennet AM, Di Angelantonio E, Ye Z, Wensley F, Dahlin A, Ahlbom A, Keavney B, Collins R, Wiman B, de Faire U, Danesh J. Association of apolipoprotein E genotypes with lipid levels and coronary risk. JAMA. 2007;298:1300-1311. (Pubitemid 47443344)
-
(2007)
Journal of the American Medical Association
, vol.298
, Issue.11
, pp. 1300-1311
-
-
Bennet, A.M.1
Di Angelantonio, E.2
Ye, Z.3
Wensley, F.4
Dahlin, A.5
Ahlbom, A.6
Keavney, B.7
Collins, R.8
Wiman, B.9
De Faire, U.10
Danesh, J.11
-
4
-
-
0028303072
-
Apolipoprotein E: Structure-function relationships
-
Weisgraber KH. Apolipoprotein E: structure-function relationships. Adv Protein Chem. 1994;45:249-302. (Pubitemid 24139890)
-
(1994)
Advances in Protein Chemistry
, vol.45
, pp. 249-302
-
-
Weisgraber, K.H.1
-
5
-
-
0029766916
-
Human apolipoprotein E4 domain interaction. Arginine 61 and glutamic acid 255 interact to direct the preference for very low density lipoproteins
-
DOI 10.1074/jbc.271.32.19053
-
Dong LM, Weisgraber KH. Human apolipoprotein E4 domain interaction. Arginine 61 and glutamic acid 255 interact to direct the preference for very low density lipoproteins. J Biol Chem. 1996;271:19053-19057. (Pubitemid 26271562)
-
(1996)
Journal of Biological Chemistry
, vol.271
, Issue.32
, pp. 19053-19057
-
-
Dong, L.-M.1
Weisgraber, K.H.2
-
6
-
-
26644459735
-
Modulation of apolipoprotein E structure by domain interaction: Differences in lipid-bound and lipid-free forms
-
DOI 10.1074/jbc.M506044200
-
Hatters DM, Budamagunta MS, Voss JC, Weisgraber KH. Modulation of apolipoprotein E structure by domain interaction: differences in lipid-bound and lipid-free forms. J Biol Chem. 2005;280:34288-34295. (Pubitemid 41443154)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.40
, pp. 34288-34295
-
-
Hatters, D.M.1
Budamagunta, M.S.2
Voss, J.C.3
Weisgraber, K.H.4
-
7
-
-
0037184994
-
Apolipoprotein E4 forms a molten globule: A potential basis for its association with disease
-
DOI 10.1074/jbc.M204898200
-
Morrow JA, Hatters DM, Lu B, Hochtl P, Oberg KA, Rupp B, Weisgraber KH. Apolipoprotein E4 forms a molten globule. A potential basis for its association with disease. J Biol Chem. 2002;277:50380-50385. (Pubitemid 36042188)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.52
, pp. 50380-50385
-
-
Morrow, J.A.1
Hatters, D.M.2
Lu, B.3
Hochtl, P.4
Oberg, K.A.5
Rupp, B.6
Weisgraber, K.H.7
-
8
-
-
0032721537
-
Apo e structure determines VLDL clearance and atherosclerosis risk in mice
-
Knouff C, Hinsdale ME, Mezdour H, Altenburg MK, Watanabe M, Quarfordt SH, Sullivan PM, Maeda N. Apo E structure determines VLDL clearance and atherosclerosis risk in mice. J Clin Invest. 1999;103:1579-1586.
-
(1999)
J Clin Invest
, vol.103
, pp. 1579-1586
-
-
Knouff, C.1
Hinsdale, M.E.2
Mezdour, H.3
Altenburg, M.K.4
Watanabe, M.5
Quarfordt, S.H.6
Sullivan, P.M.7
Maeda, N.8
-
9
-
-
44849085120
-
Human LDL receptor enhances sequestration of ApoE4 and VLDL remnants on the surface of hepatocytes but not their internalization in mice
-
Altenburg M, Arbones-Mainar J, Johnson L, Wilder J, Maeda N. Human LDL receptor enhances sequestration of ApoE4 and VLDL remnants on the surface of hepatocytes but not their internalization in mice. Arterioscler Thromb Vasc Biol. 2008;28:1104-1110.
-
(2008)
Arterioscler Thromb Vasc Biol
, vol.28
, pp. 1104-1110
-
-
Altenburg, M.1
Arbones-Mainar, J.2
Johnson, L.3
Wilder, J.4
Maeda, N.5
-
10
-
-
0036845241
-
Evidence for differential effects of apoE3 and apoE4 on HDL metabolism
-
DOI 10.1194/jlr.M200172-JLR200
-
Hopkins PC, Huang Y, McGuire JG, Pitas RE. Evidence for differential effects of apoE3 and apoE4 on HDL metabolism. J Lipid Res. 2002;43:1881-1889. (Pubitemid 35315806)
-
(2002)
Journal of Lipid Research
, vol.43
, Issue.11
, pp. 1881-1889
-
-
Hopkins, P.C.R.1
Huang, Y.2
McGuire, J.G.3
Pitas, R.E.4
-
11
-
-
0035949490
-
Introduction of human apolipoprotein E4 "domain interaction" into mouse apolipoprotein E
-
DOI 10.1073/pnas.201279298
-
Raffai RL, Dong LM, Farese RV Jr, Weisgraber KH. Introduction of human apolipoprotein E4 "domain interaction" into mouse apolipoprotein E. Proc Natl Acad Sci USA. 2001;98:11587-11591. (Pubitemid 32928772)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.20
, pp. 11587-11591
-
-
Raffai, R.L.1
Dong, L.-M.2
Farese Jr., R.V.3
Weisgraber, K.H.4
-
12
-
-
0037192774
-
Hypomorphic apolipoprotein E mice. A new model of conditional gene repair to examine apolipoprotein E-mediated metabolism
-
DOI 10.1074/jbc.M111222200
-
Raffai RL, Weisgraber KH. Hypomorphic apolipoprotein E mice: a new model of conditional gene repair to examine apolipoprotein E-mediated metabolism. J Biol Chem. 2002;277:11064-11068. (Pubitemid 34952865)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.13
, pp. 11064-11068
-
-
Raffa, R.L.1
Weisgraber, K.H.2
-
14
-
-
33644832722
-
Distinct cellular loci for the ABCA1-dependent and ABCA1-independent lipid efflux mediated by endogenous apolipoprotein E expression
-
DOI 10.1161/01.ATV.0000193627.12516.1d, PII 0004360520060100000026
-
Huang ZH, Fitzgerald ML, Mazzone T. Distinct cellular loci for the ABCA1-dependent and ABCA1-independent lipid efflux mediated by endogenous apolipoprotein E expression. Arterioscler Thromb Vasc Biol. 2006;26:157-162. (Pubitemid 43732243)
-
(2006)
Arteriosclerosis, Thrombosis, and Vascular Biology
, vol.26
, Issue.1
, pp. 157-162
-
-
Huang, Z.H.1
Fitzgerald, M.L.2
Mazzone, T.3
-
15
-
-
0038803973
-
Apolipoprotein E modulates immune activation by acting on the antigen-presenting cell
-
DOI 10.1046/j.1365-2567.2003.01665.x
-
Tenger C, Zhou X. Apolipoprotein E modulates immune activation by acting on the antigen-presenting cell. Immunology. 2003;109:392-397. (Pubitemid 36783265)
-
(2003)
Immunology
, vol.109
, Issue.3
, pp. 392-397
-
-
Tenger, C.1
Zhou, X.2
-
16
-
-
70350448412
-
Apolipoprotein E4 domain interaction induces endoplasmic reticulum stress and impairs astrocyte function
-
Zhong N, Ramaswamy G, Weisgraber KH. Apolipoprotein E4 domain interaction induces endoplasmic reticulum stress and impairs astrocyte function. J Biol Chem. 2009;284:27273-27280.
-
(2009)
J Biol Chem
, vol.284
, pp. 27273-27280
-
-
Zhong, N.1
Ramaswamy, G.2
Weisgraber, K.H.3
-
17
-
-
0346492601
-
Harmful Effects of Increased LDLR Expression in Mice with Human APOE*4 but Not APOE*3
-
DOI 10.1161/01.ATV.0000094963.07902.FB
-
Malloy SI, Altenburg MK, Knouff C, Lanningham-Foster L, Parks JS, Maeda N. Harmful effects of increased LDLR expression in mice with human APOE*4 but not APOE*3. Arterioscler Thromb Vasc Biol. 2004;24:91-97. (Pubitemid 38082417)
-
(2004)
Arteriosclerosis, Thrombosis, and Vascular Biology
, vol.24
, Issue.1
, pp. 91-97
-
-
Malloy, S.I.1
Altenburg, M.K.2
Knouff, C.3
Lanningham-Foster, L.4
Parks, J.S.5
Maeda, N.6
-
18
-
-
64349110332
-
VLDL best predicts aortic root atherosclerosis in LDL receptor deficient mice
-
VanderLaan PA, Reardon CA, Thisted RA, Getz GS. VLDL best predicts aortic root atherosclerosis in LDL receptor deficient mice. J Lipid Res. 2009;50:376-385.
-
(2009)
J Lipid Res
, vol.50
, pp. 376-385
-
-
Vanderlaan, P.A.1
Reardon, C.A.2
Thisted, R.A.3
Getz, G.S.4
-
19
-
-
33845970192
-
hi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata
-
DOI 10.1172/JCI29950
-
Swirski FK, Libby P, Aikawa E, Alcaide P, Luscinskas FW, Weissleder R, Pittet MJ. Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata. J Clin Invest. 2007;117:195-205. (Pubitemid 46048466)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.1
, pp. 195-205
-
-
Swirski, F.K.1
Libby, P.2
Aikawa, E.3
Alcaide, P.4
Luscinskas, F.W.5
Weissleder, R.6
Pittet, M.J.7
-
20
-
-
0032948510
-
Comparison of the LDL-receptor binding of VLDL and LDL from apoE4 and apoE3 homozygotes
-
Mamotte CD, Sturm M, Foo JI, van Bockxmeer FM, Taylor RR. Comparison of the LDL-receptor binding of VLDL and LDL from apoE4 and apoE3 homozygotes. Am J Physiol. 1999;276(3 Pt 1):E553-E557. (Pubitemid 29157412)
-
(1999)
American Journal of Physiology - Endocrinology and Metabolism
, vol.276
, Issue.3
-
-
Mamotte, C.D.S.1
Sturm, M.2
Foo, J.I.3
Van Bockxmeer, F.M.4
Taylor, R.R.5
-
21
-
-
33744965387
-
Structural and functional variations in human apolipoprotein E3 and E4
-
Chou CY, Jen WP, Hsieh YH, Shiao MS, Chang GG. Structural and functional variations in human apolipoprotein E3 and E4. J Biol Chem. 2006;281:13333-13344.
-
(2006)
J Biol Chem
, vol.281
, pp. 13333-13344
-
-
Chou, C.Y.1
Jen, W.P.2
Hsieh, Y.H.3
Shiao, M.S.4
Chang, G.G.5
-
22
-
-
0022449937
-
4 in humans
-
Gregg RE, Zech LA, Schaefer EJ, Stark D, Wilson D, Brewer HB Jr. Abnormal in vivo metabolism of apolipoprotein E4 in humans. J Clin Invest. 1986;78:815-821. (Pubitemid 16024820)
-
(1986)
Journal of Clinical Investigation
, vol.78
, Issue.3
, pp. 815-821
-
-
Gregg, R.E.1
Zech, L.A.2
Schaefer, E.J.3
-
23
-
-
0023481281
-
Dietary fat clearance in normal subjects is regulated by genetic variation in apolipoprotein E
-
Weintraub MS, Eisenberg S, Breslow JL. Dietary fat clearance in normal subjects is regulated by genetic variation in apolipoprotein E. J Clin Invest. 1987;80:1571-1577. (Pubitemid 18007127)
-
(1987)
Journal of Clinical Investigation
, vol.80
, Issue.6
, pp. 1571-1577
-
-
Weintraub, M.S.1
Eisenberg, S.2
Breslow, J.L.3
-
24
-
-
0030045980
-
Prolonged postprandial responses of lipids and apolipoproteins in triglyceride-rich lipoproteins of individuals expressing an apolipoprotein epsilon 4 allele
-
Bergeron N, Havel RJ. Prolonged postprandial responses of lipids and apolipoproteins in triglyceride-rich lipoproteins of individuals expressing an apolipoprotein epsilon 4 allele. J Clin Invest. 1996;97:65-72.
-
(1996)
J Clin Invest
, vol.97
, pp. 65-72
-
-
Bergeron, N.1
Havel, R.J.2
-
25
-
-
0025723924
-
Influence of apolipoprotein e polymorphism on apolipoprotein B-100 metabolism in normolipemic subjects
-
Demant T, Bedford D, Packard CJ, Shepherd J. Influence of apolipoprotein E polymorphism on apolipoprotein B-100 metabolism in normolipemic subjects. J Clin Invest. 1991;88:1490-1501.
-
(1991)
J Clin Invest
, vol.88
, pp. 1490-1501
-
-
Demant, T.1
Bedford, D.2
Packard, C.J.3
Shepherd, J.4
-
26
-
-
0032522990
-
Phenotype-dependent differences in apolipoprotein e metabolism and in cholesterol homeostasis in human monocyte-derived macrophages
-
Cullen P, Cignarella A, Brennhausen B, Mohr S, Assmann G, von Eckardstein A. Phenotype-dependent differences in apolipoprotein E metabolism and in cholesterol homeostasis in human monocyte-derived macrophages. J Clin Invest. 1998;101:1670-1677. (Pubitemid 28198496)
-
(1998)
Journal of Clinical Investigation
, vol.101
, Issue.8
, pp. 1670-1677
-
-
Cullen, P.1
Cignarella, A.2
Brennhausen, B.3
Mohr, S.4
Assmann, G.5
Von Eckardstein, A.6
-
27
-
-
0037324352
-
Isoform-dependent cholesterol efflux from macrophages by apolipoprotein E is modulated by cell surface proteoglycans
-
DOI 10.1161/01.ATV.0000054199.78458.4B
-
Hara M, Matsushima T, Satoh H, Iso-o N, Noto H, Togo M, Kimura S, Hashimoto Y, Tsukamoto K. Isoform-dependent cholesterol efflux from macrophages by apolipoprotein E is modulated by cell surface proteoglycans. Arterioscler Thromb Vasc Biol. 2003;23:269-274. (Pubitemid 36231939)
-
(2003)
Arteriosclerosis, Thrombosis, and Vascular Biology
, vol.23
, Issue.2
, pp. 269-274
-
-
Hara, M.1
Matsushima, T.2
Satoh, H.3
Iso-o, N.4
Noto, H.5
Togo, M.6
Kimura, S.7
Hashimoto, Y.8
Tsukamoto, K.9
-
28
-
-
33846884827
-
Regulation of macrophage apoE secretion and sterol efflux by the LDL receptor
-
DOI 10.1194/jlr.M600259-JLR200
-
Lucic D, Huang ZH, Gu de S, Altenburg MK, Maeda N, Mazzone T. Regulation of macrophage apoE secretion and sterol efflux by the LDL receptor. J Lipid Res. 2007;48:366-372. (Pubitemid 46220603)
-
(2007)
Journal of Lipid Research
, vol.48
, Issue.2
, pp. 366-372
-
-
Lucic, D.1
Zhi, H.H.2
De, S.G.3
Altenburg, M.K.4
Maeda, N.5
Mazzone, T.6
-
29
-
-
79955754372
-
Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors
-
Brodbeck J, McGuire J, Liu Z, Meyer-Franke A, Balestra ME, Jeong DE, Pleiss M, McComas C, Hess F, Witter D, Peterson S, Childers M, Goulet M, Liverton N, Hargreaves R, Freedman S, Weisgraber KH, Mahley RW, Huang Y. Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors. J Biol Chem. 2011;286:17217-17226.
-
(2011)
J Biol Chem
, vol.286
, pp. 17217-17226
-
-
Brodbeck, J.1
McGuire, J.2
Liu, Z.3
Meyer-Franke, A.4
Balestra, M.E.5
Jeong, D.E.6
Pleiss, M.7
McComas, C.8
Hess, F.9
Witter, D.10
Peterson, S.11
Childers, M.12
Goulet, M.13
Liverton, N.14
Hargreaves, R.15
Freedman, S.16
Weisgraber, K.H.17
Mahley, R.W.18
Huang, Y.19
-
30
-
-
0029804198
-
Cyclic AMP induces apolipoprotein E binding activity and promotes cholesterol efflux from a macrophage cell line to apolipoprotein acceptors
-
DOI 10.1074/jbc.271.48.30647
-
Smith JD, Miyata M, Ginsberg M, Grigaux C, Shmookler E, Plump AS. Cyclic AMP induces apolipoprotein E binding activity and promotes cholesterol efflux from a macrophage cell line to apolipoprotein acceptors. J Biol Chem. 1996;271:30647-30655. (Pubitemid 26404080)
-
(1996)
Journal of Biological Chemistry
, vol.271
, Issue.48
, pp. 30647-30655
-
-
Smith, J.D.1
Miyata, M.2
Ginsberg, M.3
Grigaux, C.4
Shmookler, E.5
Plump, A.S.6
-
31
-
-
34247194155
-
Apolipoprotein E4 in macrophages enhances atherogenesis in a low density lipoprotein receptor-dependent manner
-
DOI 10.1074/jbc.M610712200
-
Altenburg M, Johnson L, Wilder J, Maeda N. Apolipoprotein E4 in macrophages enhances atherogenesis in a low density lipoprotein receptor-dependent manner. J Biol Chem. 2007;282:7817-7824. (Pubitemid 47093587)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.11
, pp. 7817-7824
-
-
Altenburg, M.1
Johnson, L.2
Wilder, J.3
Maeda, N.4
-
32
-
-
0020665553
-
Independent pathways for secretion of cholesterol and apolipoprotein E by macrophages
-
Basu SK, Goldstein JL, Brown MS. Independent pathways for secretion of cholesterol and apolipoprotein E by macrophages. Science. 1983;219:871-873. (Pubitemid 13194778)
-
(1983)
Science
, vol.219
, Issue.4586
, pp. 871-873
-
-
Basu, S.K.1
Goldstein, J.L.2
Brown, M.S.3
-
33
-
-
79958709822
-
APOE e3 attenuates experimental autoimmune neuritis by modulating T cell, macrophage and Schwann cell functions
-
Zhang HL, Mao XJ, Zhang XM, Li HF, Zheng XY, Adem A, Mix E, Zhu J. APOE e3 attenuates experimental autoimmune neuritis by modulating T cell, macrophage and Schwann cell functions. Exp Neurol. 2011;230:197-206.
-
(2011)
Exp Neurol
, vol.230
, pp. 197-206
-
-
Zhang, H.L.1
Mao, X.J.2
Zhang, X.M.3
Li, H.F.4
Zheng, X.Y.5
Adem, A.6
Mix, E.7
Zhu, J.8
-
34
-
-
79951669207
-
The immune system in atherosclerosis
-
Hansson GK, Hermansson A. The immune system in atherosclerosis. Nat Immunol. 2011;12:204-212.
-
(2011)
Nat Immunol
, vol.12
, pp. 204-212
-
-
Hansson, G.K.1
Hermansson, A.2
-
35
-
-
32244445416
-
Natural regulatory T cells control the development of atherosclerosis in mice
-
DOI 10.1038/nm1343, PII NM1343
-
Ait-Oufella H, Salomon BL, Potteaux S, Robertson AK, Gourdy P, Zoll J, Merval R, Esposito B, Cohen JL, Fisson S, Flavell RA, Hansson GK, Klatzmann D, Tedgui A, Mallat Z. Natural regulatory T cells control the development of atherosclerosis in mice. Nat Med. 2006;12:178-180. (Pubitemid 43214743)
-
(2006)
Nature Medicine
, vol.12
, Issue.2
, pp. 178-180
-
-
Ait-Oufella, H.1
Salomon, B.L.2
Potteaux, S.3
Robertson, A.-K.L.4
Gourdy, P.5
Zoll, J.6
Merval, R.7
Esposito, B.8
Cohen, J.L.9
Fisson, S.10
Flavell, R.A.11
Hansson, G.K.12
Klatzmann, D.13
Tedgui, A.14
Mallat, Z.15
-
36
-
-
66349085616
-
Apolipoprotein E: Structure determines function, from atherosclerosis to Alzheimer's disease to AIDS
-
Mahley RW, Weisgraber KH, Huang Y. Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS.J Lipid Res. 2009;50 Suppl:S183-S188.
-
(2009)
J Lipid Res
, vol.50
, Issue.SUPPL.
-
-
Mahley, R.W.1
Weisgraber, K.H.2
Huang, Y.3
-
37
-
-
43649084798
-
Apolipoprotein E4 domain interaction: Synaptic and cognitive deficits in mice
-
DOI 10.1016/j.jalz.2008.01.006, PII S1552526008000782
-
Zhong N, Scearce-Levie K, Ramaswamy G, Weisgraber KH. Apolipoprotein E4 domain interaction: synaptic and cognitive deficits in mice. Alzheimers Dement. 2008;4:179-192. (Pubitemid 351682263)
-
(2008)
Alzheimer's and Dementia
, vol.4
, Issue.3
, pp. 179-192
-
-
Zhong, N.1
Scearce-Levie, K.2
Ramaswamy, G.3
Weisgraber, K.H.4
-
38
-
-
79953130715
-
Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease
-
Chen HK, Ji ZS, Dodson SE, Miranda RD, Rosenblum CI, Reynolds IJ, Freedman SB, Weisgraber KH, Huang Y, Mahley RW. Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease. J Biol Chem. 2011;286:5215-5221.
-
(2011)
J Biol Chem
, vol.286
, pp. 5215-5221
-
-
Chen, H.K.1
Ji, Z.S.2
Dodson, S.E.3
Miranda, R.D.4
Rosenblum, C.I.5
Reynolds, I.J.6
Freedman, S.B.7
Weisgraber, K.H.8
Huang, Y.9
Mahley, R.W.10
|