Towards defining a rigidity-associated pathogenic pathway in idiopathic parkinsonism

Neurodegenerative Diseases

Volumn 10, Issue 1-4, 2012, Pages 183-186

  Dobbs, R John ^a,b,c   Charlett, André ^a,d   Dobbs, Sylvia M ^a,b,c   Weller, Clive ^a   Iguodala, Owens ^b   Smee, Cori ^b   Bowthorpe, James ^b   Taylor, David ^a,b   Bjarnason, Ingvar T ^c  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b SOUTH LONDON AND MAUDSLEY NHS FOUNDATION TRUST   (United Kingdom)

^c KING S COLLEGE HOSPITAL   (United Kingdom)

^d PUBLIC HEALTH ENGLAND   (United Kingdom)

Author keywords

Aetiology pathogenesis; Brady hypokinesia; Helicobacter; Idiopathic parkinsonism; Natural killer lymphocytes; Rigidity; Small intestinal bacterial overgrowth; T helper lymphocytes

Indexed keywords

BIOLOGICAL MARKER; CYANOCOBALAMIN;

ARTICLE; BACTERIAL GROWTH; BLOOD CELL COUNT; BRADYKINESIA; DISEASE COURSE; DUODENUM; GASTRIC ATROPHY; HELICOBACTER INFECTION; HUMAN; HYPERHOMOCYSTEINEMIA; HYPOKINESIA; IDIOPATHIC DISEASE; INFLAMMATION; INTESTINE CELL; INTESTINE FLORA; LYSOSOME; NATURAL KILLER CELL; NONHUMAN; PARKINSONISM; PATHOGENESIS; PRIORITY JOURNAL; RIGIDITY; STOMACH DISEASE; TH1 CELL; VITAMIN BLOOD LEVEL;

HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; HYPERHOMOCYSTEINEMIA; KILLER CELLS, NATURAL; MUSCLE RIGIDITY; PARKINSON DISEASE; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 84860217968     PISSN: 16602854     EISSN: 16602862     Source Type: Journal    
DOI: 10.1159/000332807     Document Type: Article

References (5)

1. Dobbs RJ, Dobbs SM, Weller C, et al: Helicobacter hypothesis for idiopathic parkinsonism: before and beyond. Helicobacter 2008; 13: 309-322.
2. Charlett A, Dobbs RJ, Dobbs SM, et al: Blood profile holds clues to role of infection in a premonitory state for idiopathic parkinsonism and of gastrointestinal infection in established disease. Gut Pathog 2009; 1: 20.
3. Weller C, Charlett A, Oxlade NL, et al: Role of chronic infection and inflammation in the gastrointestinal tract in the etiology and pathogenesis of idiopathic parkinsonism. 3. Predicted probability and gradients of severity of idiopathic parkinsonism based on H. pylori antibody profile. Helicobacter 2005; 10: 288-297.
4. Dobbs RJ, Dobbs SM, Weller C, et al: Role of chronic infection and inflammation in the gastrointestinal tract in the etiology and pathogenesis of idiopathic parkinsonism. 1. Eradication of Helicobacter in the cachexia of idiopathic parkinsonism. Helicobacter 2005; 10: 267-275.
5. Dobbs SM, Dobbs RJ, Weller C, et al: Differential effect of Helicobacter pylori eradication on time trends in brady/hypokinesia and rigidity in idiopathic parkinsonism. Helicobacter 2010; 15: 279-294.