Evaluation of the performance of novel Aβ isoforms as theragnostic markers in Alzheimer's disease: From the cell to the patient

Neurodegenerative Diseases

Volumn 10, Issue 1-4, 2012, Pages 138-140

  Portelius, Erik ^a,b   Gustavsson, Mikael K ^a   Zetterberg, Henrik ^a   Andreasson, Ulf ^a   Blennow, Kaj ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Secretase; Alzheimer's disease; Amyloid ; Biomarkers; Cerebrospinal fluid

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-14]; AMYLOID BETA PROTEIN[1-15]; AMYLOID BETA PROTEIN[1-16]; BIOLOGICAL MARKER; E 2012; GAMMA SECRETASE INHIBITOR; GLYCOPROTEIN; SEMAGACESTAT; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL CULTURE; CEREBROSPINAL FLUID; CLINICAL ARTICLE; CONTROLLED STUDY; CULTURE MEDIUM; DIAGNOSTIC TEST; DOG; DOSE RESPONSE; DRUG EFFICACY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOUSE; NONHUMAN; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; PROTEIN PROCESSING; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE; TREATMENT RESPONSE;

ALANINE; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ANTIBODIES, MONOCLONAL; AZEPINES; DOGS; ENZYME INHIBITORS; HUMANS; IMMUNOPRECIPITATION; MICE; PROTEIN ISOFORMS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 84860215636     PISSN: 16602854     EISSN: 16602862     Source Type: Journal    
DOI: 10.1159/000334537     Document Type: Article

References (11)

1. Portelius E, Zetterberg H, Gobom J, Andreasson U, Blennow K: Targeted proteomics in Alzheimer's disease: focus on amyloid-beta. Expert Rev Proteomics 2008; 5: 225-237.
2. Blennow K, Hampel H, Weiner M, Zetterberg H: Cerebrospinal fluid and plasma biomarkers in Alzheimer disease. Nat Rev Neurol 2010;6: 131-144.
3. Hampel H, Frank R, Broich K, Teipel SJ, Katz RG, Hardy J, Herholz K, Bokde AL, Jessen F, Hoessler YC, Sanhai WR, Zetterberg H, Woodcock J, Blennow K: Biomarkers for Alz heimer's disease: academic, industry and regulatory perspectives. Nat Rev Drug Discov 2010; 9: 560-574.
4. Cummings JL: Biomarkers in Alzheimer's disease drug development. Alzheimers Dement 2011; 7:e13-e44.
5. Portelius E, Tran AJ, Andreasson U, Persson R, Brinkmalm G, Zetterberg H, Blennow K, Westman-Brinkmalm A: Characterization of amyloid beta peptides in cerebrospinal fluid by an automated immunoprecipitation procedure followed by mass spectrometry. J Proteome Res 2007; 6: 4433-4439.
6. Portelius E, Price E, Brinkmalm G, Stiteler M, Olsson M, Persson R, Westman-Brinkmalm A, Zetterberg H, Simon AJ, Blennow K: A novel pathway for amyloid precursor protein processing. Neurobiol Aging 2011; 32: 1090-1098.
7. Portelius E, Zhang B, Gustavsson MK, Brinkmalm G, Westman-Brinkmalm A, Zetterberg H, Lee VM, Trojanowski JQ, Blennow K: Effects of gamma-secretase inhibition on the amyloid beta isoform pattern in a mouse model of Alzheimer's disease. Neurodegener Dis 2009; 6: 258-262.
8. Portelius E, Van Broeck B, Andreasson U, Gustavsson MK, Mercken M, Zetterberg H, Borghys H, Blennow K: Acute effect on the Abeta isoform pattern in CSF in response to gamma-secretase modulator and inhibitor treatment in dogs. J Alzheimers Dis 2010; 21: 1005-1012.
9. Fleisher AS, Raman R, Siemers ER, Becerra L, Clark CM, Dean RA, Farlow MR, Galvin JE, Peskind ER, Quinn JF, Sherzai A, Sowell BB, Aisen PS, Thal LJ: Phase 2 safety trial targeting amyloid beta production with a gamma- secretase inhibitor in Alzheimer disease. Arch Neurol 2008; 65: 1031-1038.
10. Cook JJ, Wildsmith KR, Gilberto DB, Holahan MA, Kinney GG, Mathers PD, Michener MS, Price EA, Shearman MS, Simon AJ, Wang JX, Wu G, Yarasheski KE, Bateman RJ: Acute gamma-secretase inhibition of nonhuman primate CNS shifts amyloid precursor protein (APP) metabolism from amyloidbeta production to alternative APP fragments without amyloid-beta rebound, J Neurosci 2010; 30: 6743-6750.
11. Portelius E, Dean RA, Gustavsson MK, Andreasson U, Zetterberg H, Siemers E, Blennow K: A novel Abeta isoform pattern in CSF reflects gamma-secretase inhibition in Alz heimer disease. Alzheimers Res Ther 2010; 2: 7.