Glyceraldehyde-3-phosphate, a glycolytic intermediate, prevents cells from apoptosis by lowering S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase

Journal of Microbiology and Biotechnology

Volumn 22, Issue 4, 2012, Pages 571-573

  Lee, Sun Young ^a,b   Kim, Jeong Hoon ^a   Jung, Hyeyun ^a   Chi, Seung Wook ^a   Chung, Sang J ^a   Lee, Chong Kil ^b   Park, Byoung Chul ^a   Bae, Kwang Hee ^a   Park, Sung Goo ^a  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b Chungbuk National University   (South Korea)

Author keywords

Apoptosis; GAPDH; Glyceraldehyde 3 phosphate; S nitrosylation

Indexed keywords

CASPASE 3; CELL ENZYME; CYSTEINE; GLYCERALDEHYDE 3 PHOSPHATE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; NITROUS OXIDE; UBIQUITIN PROTEIN LIGASE E3;

APOPTOSIS; ARTICLE; CELL FATE; CELL SURVIVAL; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; NITROSYLATION;

APOPTOSIS; CASPASE 3; CELLS; GLYCERALDEHYDE 3-PHOSPHATE; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; HELA CELLS; HUMANS;

EID: 84860203665     PISSN: 10177825     EISSN: 17388872     Source Type: Journal    
DOI: 10.4014/jmb.1110.10010     Document Type: Article

References (15)

1. Bao, Q. and Y. Shi. 2007. Apoptosome: A platform for the activation of initiator caspases. Cell Death Diff. 14: 56-65.
2. Brown, G. C. 2010. Nitric oxide and neuronal death. Nitric Oxide 23: 153-165.
3. Chuang, D.-M., C. Hough, and V. V. Senatorov. 2005. Glyceraldehyde-3-phosphate dehydrogenase, apoptosis, and neurodegenerative diseases. Annu. Rev. Pharmacol. Toxicol. 45: 269-290.
4. Hara, M. R., M. B. Cascio, and A. Sawa. 2006. GAPDH as a sensor of NO stress. Biochim. Biophys. Acta 1762: 502-509.
5. Hara, M. R., B. Thomas, M. B. Cascio, B.-I. Bae, L. D. Hester, V. L. Dawson, et al. 2006. Neuroprotection by pharmacological blockade of the GAPDH death cascade. Proc. Natl. Acad. Sci. USA 103: 3887-3889.
6. Ishitani, R., K. Sunaga, A. Hirano, P. Saunders, N. Katsube, M. Tanaka, and D. M. Chuang. 1996. Evidence that glyceraldehyde-3-phosphate dehydrogenase is involved in ageinduced apoptosis in mature cerebellar granule neurons in culture. J. Neurochem. 66: 928-935.
7. Jang, M., H. J. Kang, S. Y. Lee, S. J. Chung, S. Kang, S. W. Chi, et al. 2009. Glyceraldehyde-3-phosphate, a glycolytic intermediate, plays a key role in controlling cell fate via inhibition of caspase activity. Mol. Cells 28: 559-563.
8. Jang, M., B. C. Park, S. Kang, S.-W. Chi, S. Cho, S. J. Chung, et al. 2009. Far upstream element-binding protein-1, a novel caspase substrate, acts as a cross-talker between apoptosis and the c-myc oncogene. Oncogene 28: 1529-1536.
9. Kim, E. Y., T.-S. Yoon, Y. J. Bahn, D. G. Jeong, M. R. Park, S. J. Chung, et al. 2010. Proteomic analysis of oxidative stressinduced neuronal cell death by two-dimensional fluorescence difference gel electrophoresis. Int. J. Mol. Med. 26: 829-835.
10. Kumar, S. 2007. Caspase function in programmed cell death. Cell Death Diff. 14: 32-43.
11. Li, C., Z. Xiao, X. Zhang, J. Li, X. Li, H. Yi, et al. 2006. Proteome analysis of human lung squamous carcinoma. Proteomics 6: 547-558.
12. Nicholls, C., H. Li, and J. P. Liu. 2011. GAPDH: A common enzyme with uncommon functions. DOI: 10.1111/j.1440-1681.2011.05599.x.
13. Sen, N., M. R. Hara, M. D. Kornberg, M. B. Cascio, B.-I. Bae, N. Shahani, et al. 2008. Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis. Nature Cell Biol. 10: 866-873.
14. Shahani, N. and A. Sawa. 2011. Nitric oxide signaling and nitrosative stress in neurons: Role for S-nitrosylation. Antioxid. Redox Signal. 14: 1493-1504.
15. Tristan, C., N. Shahani, T. W. Sedlak, and A. Sawa. 2011. The diverse functions of GAPDH: Views from different subcellular compartments. Cell Signal. 23: 317-323.