Age-dependent lethality in novel transgenic mouse models of central nervous system arteriovenous malformations

Stroke

Volumn 43, Issue 5, 2012, Pages 1432-1435

  Milton, Ian ^a   Ouyang, Dan ^a   Allen, Caitlin J ^a   Yanasak, Nathan E ^a   Gossage, James R ^a   Alleyne, Cargill H ^a   Seki, Tsugio ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Activin receptor like kinase 1; Arteriovenous malformation; Hereditary hemorrhagic telangiectasia; Intracranial hemorrhage; Stroke

Indexed keywords

ACTIVIN RECEPTOR LIKE KINASE 1; ANGIOPOIETIN 2; TRANSGELIN;

AGE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ARTERIOVENOUS MALFORMATION; BRAIN HEMORRHAGE; CONTROLLED STUDY; FEMALE; GENE DELETION; LETHALITY; MALE; MOUSE; NONHUMAN; PARALYSIS; PHENOTYPE; PRIORITY JOURNAL; TRANSGENIC MOUSE; UPREGULATION;

ACTIVIN RECEPTORS; AGING; ANGIOPOIETIN-2; ANIMALS; INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; INTRACRANIAL HEMORRHAGES; MICE; MICE, MUTANT STRAINS; MICE, TRANSGENIC; MICROFILAMENT PROTEINS; MODELS, ANIMAL; MUSCLE PROTEINS; PREVALENCE; RISK FACTORS; UP-REGULATION;

EID: 84860202951     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.111.647024     Document Type: Article

References (11)

1. Oh SP, Seki T, Goss KA, Imamura T, Yi Y, Donahoe PK, et al. Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis. Proc Natl Acad Sci USA. 2000;97: 2626-2631. (Pubitemid 30159221)
2. Seki T, Yun J, Oh SP. Arterial endothelium-specific activin receptor-like kinase 1 expression suggests its role in arterialization and vascular remodeling. Circulation research. 2003;93:682-689. (Pubitemid 37222165)
3. Park SO, Lee YJ, Seki T, Hong KH, Fliess N, Jiang Z, et al. Alk5-and TGFBR2-independent role of alk1 in the pathogenesis of hereditary hemorrhagic telangiectasia type 2. Blood. 2008;111:633-642.
4. Park SO, Wankhede M, Lee YJ, Choi EJ, Fliess N, Choe SW, et al. Real-time imaging of de novo arteriovenous malformation in a mouse model of hereditary hemorrhagic telangiectasia. J Clin Invest. 2009;119:3487-3496.
5. Walker EJ, Su H, Shen F, Choi EJ, Oh SP, Chen G, et al. Arteriovenous malformation in the adult mouse brain resembling the human disease. Ann Neurol. 2011;69:954-962.
6. Holtwick R, Gotthardt M, Skryabin B, Steinmetz M, Potthast R, Zetsche B, et al. Smooth muscle-selective deletion of guanylyl cyclase-a prevents the acute but not chronic effects of ANP on blood pressure. Proc Natl Acad Sci USA. 2002;99:7142-7147. (Pubitemid 34526269)
7. Soriano P. Generalized LACZ expression with the ROSA26 Cre reporter strain. Nat Genet. 1999;21:70-71. (Pubitemid 29036285)
8. Chen Y, Zhu W, Bollen AW, Lawton MT, Barbaro NM, Dowd CF, et al. Evidence of inflammatory cell involvement in brain arteriovenous malformations. Neurosurgery. 2008;62:1340-1349; discussion 1349-1350.
9. Kim H, Su H, Weinsheimer S, Pawlikowska L, Young WL. Brain arteriovenous malformation pathogenesis: A response-to-injury paradigm. Acta neurochirurgica. Supplement. 2011;111:83-92.
10. Hashimoto T, Lam T, Boudreau NJ, Bollen AW, Lawton MT, Young WL. Abnormal balance in the angiopoietin-tie2 system in human brain arteriovenous malformations. Circulation research. 2001;89:111-113. (Pubitemid 34135816)
11. Chen Y, Pawlikowska L, Yao JS, Shen F, Zhai W, Achrol AS, et al. Interleukin-6 involvement in brain arteriovenous malformations. Ann Neurol. 2006;59:72-80. (Pubitemid 43042873)