Antifungal therapy in the treatment of chronic rhinosinusitis: A meta-analysis

American Journal of Rhinology and Allergy

Volumn 26, Issue 2, 2012, Pages 141-147

  Sacks IV, Peta Lee ^a   Harvey, Richard J ^a,b   Rimmer, Janet ^b   Gallagher, Richard M ^a,b   Sacks, Raymond ^c,d  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b ST VINCENT S HOSPITAL   (Australia)

^c Centre for Education and Research on Aging   (Australia)

^d UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; ANTIFUNGAL AGENT; PLACEBO; TERBINAFINE;

ARTICLE; ASTHMA; BRONCHITIS; CHRONIC RHINOSINUSITIS; CLINICAL TRIAL; COUGHING; CYSTITIS; EPISTAXIS; FACE PAIN; HUMAN; META ANALYSIS; MYALGIA; NASAL BURNING; NOSE CONGESTION; PRURITUS; RASH; RHINORRHEA; RHINOSINUSITIS; SYSTEMATIC REVIEW; THERAPY EFFECT; TREATMENT OUTCOME;

ANTIFUNGAL AGENTS; CHRONIC DISEASE; DISEASE MANAGEMENT; HUMANS; MICONAZOLE; MYCOSES; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RHINITIS; SINUSITIS; TREATMENT OUTCOME;

EID: 84860155262     PISSN: 19458924     EISSN: 19458932     Source Type: Journal    
DOI: 10.2500/ajra.2012.26.3710     Document Type: Article

References (48)

1. Fokkens W, Lund V, and Mullol J. European position paper on rhinosinusitis and nasal polyps 2007. Rhinol Suppl 20:1-136, 2007.
2. Hutcheson PS, Schubert MS, and Slavin RG. Distinctions between allergic fungal rhinosinusitis and chronic rhinosinusitis. Am J Rhinol Allergy 24:405-408.
3. Ponikau JU, Sherris DA, Kern EB, et al. The diagnosis and incidence of allergic fungal sinusitis. Mayo Clin Proc 74:877-884, 1999. (Pubitemid 29430354)
4. Lackner A, Stammberger H, Buzina W, et al. Fungi: A normal content of human nasal mucus. Am J Rhinol 19:125-129, 2005. (Pubitemid 40775014)
5. Ebbens FA, Georgalas C, Rinia AB, et al. The fungal debate: Where do we stand today? Rhinology 45:178-189, 2007.
6. Ponikau JU, Sherris DA, and Kita H. The role of ubiquitous airborne fungi in chronic rhinosinusitis. Clin Allergy Immunol 20:177-184, 2007.
7. Gliklich RE, and Metson R. The health impact of chronic sinusitis in patients seeking otolaryngologic care. Otolaryngol Head Neck Surg 113:104-109, 1995.
8. Metson RB, and Gliklich RE. Clinical outcomes in patients with chronic sinusitis. Laryngoscope 110:24-28, 2000. (Pubitemid 30140373)
9. Ebbens F, Bachert C, Mullol J, et al. Amphotericin B nasal lavages equally as effective as placebo. Clin Otolaryngol Allied Sci 31:169, 2006.
10. Meltzer EO, Hamilos DL, Hadley JA, et al. Rhinosinusitis: Developing guidance for clinical trials. J Allergy Clin Immunol 118(suppl):S17-S61, 2006. (Pubitemid 44648297)
11. Fokkens W, Lund V, and Mullol J. EP3OS 2007: European position paper on rhinosinusitis and nasal polyps 2007. A summary for otorhinolaryngologists. Rhinology 45:97-101, 2007.
12. Benninger MS, Ferguson BJ, Hadley JA, et al. Adult chronic rhinosinusitis: Definitions, diagnosis, epidemiology, and pathophysiology. Otolaryngol Head Neck Surg 129(suppl):S1-S32, 2003.
13. Morpeth JF, Rupp NT, Dolen WK, et al. Fungal sinusitis: An update. Ann Allergy Asthma Immunol 76:128-139, 1996.
14. Piccirillo JF, Merritt MG Jr, and Richards ML. Psychometric and clinimetric validity of the 20-Item Sino-Nasal Outcome Test (SNOT-20). Otolaryngol Head Neck Surg 126:41-47, 2002. (Pubitemid 41122866)
15. Higgins JPT, and Green S. Cochrane Handbook for Systematic Reviews of Interventions, Version 5.0.2. The Cochrane Collaboration, 2008 (updated September 2009; cited 2010). Available online at www.cochrane-handbook.org; accessed November 2010.
16. Gerlinger I, Fittler A, Mayer A, et al. Postoperative application of amphotericin B nasal spray in chronic rhinosinusitis with nasal polyposis. Can recidive polyposis be prevented? Orv Hetil 149:1737-1746, 2008.
17. Riechelmann H. Fungus and nasal polyps. International Consensus Conference on Nasal Polyposis, Brussels, Belgium, April 23-25 2004.
18. Sherris DA, Ponikau JU, Weaver A, et al. Treatment of chronic rhinosinusitis with intranasal amphotericin B: A prospective, randomized, placebo-controlled trial. Program and Abstracts of papers presented at the Scientific Sessions of the American Academy of Allergy, Asthma, and Immunology (AAAAI) 60th Annual Meeting, San Francisco, CA, pS331, 2004.
19. Chan KO, Genoway KA, and Javer AR. Effectiveness of itraconazole in the management of refractory allergic fungal rhinosinusitis. J Otolaryngol Head Neck Surg 37:870-874, 2008.
20. Gupta R, Bahadur S, Thakar A, et al. Management protocols of allergic fungal sinusitis. Ind J Otolaryngol Head Neck Surg 59:35-40, 2007.
21. Helbling A, Baumann A, Hanni C, and Caversaccio M. Amphotericin B nasal spray has no effect on nasal polyps. J Laryngol Otol 120:1023-1025, 2006. (Pubitemid 46132584)
22. Hofman T, Skrobisz W, Hofman A, and Hofman M. The estimation of efficacy of fluconazole treatment in patients with chronic sinusitis. Mikologia Lekarska 11:297-301, 2004. (Pubitemid 40064779)
23. Jen A, Kacker A, Huang C, and Anand V. Fluconazole nasal spray in the treatment of allergic fungal sinusitis: A pilot study. Ear Nose Throat J 83:692, 4-5, 2004.
24. Ponikau JU, Sherris DA, Kita H, and Kern EB. Intranasal antifungal treatment in 51 patients with chronic rhinosinusitis. J Allergy Clin Immunol 110:862-866, 2002. (Pubitemid 36005872)
25. Shin SH, and Ye MK. Effects of topical amphotericin B on expression of cytokines in nasal polyps. Acta Otolaryngol 124:1174-1177, 2004.
26. Accentia-Biopharmaceuticals. A prospective, randomized, double-blind, placebo-controlled, multicenter, parallel-group study of intranasal amphotericin B suspension in patients with refractory, postsurgical chronic sinusitis (CS) 2008 (cited 2009). Available online at www.clinicaltrials.gov/ct2/show/ NCT00425620; accessed January 2011.
27. Deka RC, Chokkalingam V, Vishnoi RK, and Kumar R. Topical Amphotericin B and steroid in AFS. Otolaryngol Head and Neck Surg 137(suppl 1):P40, 2007.
28. Mosges R, Spaeth J, Berger K, and Dubois F. Topical treatment of rhinosinusitis with fusafungine nasal spray. A double-blind, placebo-controlled, parallel-group study in 20 patients. Arzneimittelforschung 52:877-883, 2002. (Pubitemid 36033184)
29. Ebbens FA, Georgalas C, Luiten S, et al. The effect of topical amphotericin B on inflammatory markers in patients with chronic rhinosinusitis: A multicenter randomized controlled study. Laryngoscope 119:401-408, 2009.
30. Weschta M, Rimek D, Formanek M, et al. Effect of nasal antifungal therapy on nasal cell activation markers in chronic rhinosinusitis. Arch Otolaryngol Head Neck Surg 132:743-747, 2006. (Pubitemid 44086436)
31. Frigas E. A pilot, prospective, double blind, placebo-controlled treatment trial with itraconazole orally in patients with chronic rhinosinusitis and asthma. J Allergy Clin Immunol 119:S142, 2007.
32. Lopatin AS, Akulich II, and Kochetkov PA. Systemic antifungals in the treatment of nasal polyposis: Do they work? International Consensus Conference on Nasal Polyposis, Brussels, Belgium, April 23-25, 2004.
33. Stergiou A, Casiano R, Katz L, et al., editors. Intranasal amphotericin B in patients with refractory, postsurgical chronic sinusitis: A phase III pivotal clinical trial design. The XXVI Congress of the European Academy of Allergology and Clinical Immunology (EAACI), Goteborg, Sweden, June 9-13, 2007.
34. Jadad AR, Moore RA, Carroll D, et al. Assessing the quality of reports of randomized clinical trials: Is blinding necessary? Control Clin Trials 17:1-12, 1996. (Pubitemid 26120810)
35. Ebbens FA, Scadding GK, Badia L, et al. Amphotericin B nasal lavages: Not a solution for patients with chronic rhinosinusitis. J Allergy Clin Immunol 118:1149-1156, 2006. (Pubitemid 44666994)
36. Gerlinger I, Fittler A, Fonai F, et al. Postoperative application of amphotericin B nasal spray in chronic rhinosinusitis with nasal polyposis, with a review of the antifungal therapy. Eur Arch Otorhinolaryngol 266:847-855, 2009.
37. Liang KL, Su MC, Shiao JY, et al. Amphotericin B irrigation for the treatment of chronic rhinosinusitis without nasal polyps: A randomized, placebo-controlled, double-blind study. Am J Rhinol 22:52-58, 2008.
38. Ponikau JU, Sherris DA, Weaver A, and Kita H. Treatment of chronic rhinosinusitis with intranasal amphotericin B: A randomized, placebo-controlled, double-blind pilot trial. J Allergy Clin Immunol 115:125-131, 2005. (Pubitemid 40075432)
39. Kennedy DW, Kuhn FA, Hamilos DL, et al. Treatment of chronic rhinosinusitis with high-dose oral terbinafine: A double blind, placebo-controlled study. Laryngoscope 115:1793-1799, 2005. (Pubitemid 41475891)
40. Weschta M, Rimek D, Formanek M, et al. Topical antifungal treatment of chronic rhinosinusitis with nasal polyps: A randomized, double-blind clinical trial. J Allergy Clin Immunol 113:1122-1128, 2004. (Pubitemid 38857995)
41. Ponikau J. Inventor methods and materials for treating and preventing inflammation of mucosal tissue. United States of America, April 29, 2003. Patent number 6207703.
42. Harvey RJ, Goddard JC, Wise SK, and Schlosser RJ. Effects of endoscopic sinus surgery and delivery device on cadaver sinus irrigation. Otolaryngol Head Neck Surg 139:137-142, 2008. (Pubitemid 351862357)
43. Grobler A, Weitzel EK, Buele A, et al. Pre- and postoperative sinus penetration of nasal irrigation. Laryngoscope 118:2078-2081, 2008.
44. Beule A, Athanasiadis T, Athanasiadis E, et al. Efficacy of different techniques of sinonasal irrigation after modified Lothrop procedure. Am J Rhinol Allergy 23:85-90, 2009.
45. Shirazi MA, Stankiewicz JA, and Kammeyer P. Activity of nasal amphotericin B irrigation against fungal organisms in vitro. Am J Rhinol 21:145-148, 2007. (Pubitemid 46846341)
46. Lim M, Citardi MJ, and Leong JL. Topical antimicrobials in the management of chronic rhinosinusitis: A systematic review. Am J Rhinol 22:381-389, 2008.
47. Desrosiers MY, and Salas-Prato M. Treatment of chronic rhinosinusitis refractory to other treatments with topical antibiotic therapy delivered by means of a large-particle nebulizer: Results of a controlled trial. Otolaryngol Head Neck Surg 125:265-269, 2001. (Pubitemid 33662678)
48. Sykes DA, Wilson R, Chan KL, et al. Relative importance of antibiotic and improved clearance in topical treatment of chronic mucopurulent rhinosinusitis. A controlled study. Lancet 2:359-360, 1986. (Pubitemid 16036499)