Is light-emitting diode phototherapy (LED-LLLT) really effective?

Laser Therapy

Volumn 20, Issue 3, 2011, Pages 205-215

  Kim, Won Serk ^a   Glen Calderhead, R ^b  

^a Sungkyunkwan University School of Medicine   (South Korea)

^b Korean Institute for Photomedicine and Photosurgery Research   (South Korea)

Author keywords

Acne rosacea; Dissecting cellulitis; Grotthus draper law; Irritant contact dermatitis; Nonhealing wound; Photochemical cascade; Photophysi cal reaction

Indexed keywords

CHEMOKINE; CYTOKINE;

ARTICLE; CHRONIC PAIN; CLINICAL EFFECTIVENESS; DISEASE ASSOCIATION; HUMAN; LIGHT EMITTING DIODE; LOW LEVEL LASER THERAPY; NEODYMIUM LASER; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PATIENT SATISFACTION; PHOTOTHERAPY; REJUVENATION; SKIN CARE; SKIN INFLAMMATION; THERAPY EFFECT; TREATMENT INDICATION; WOUND HEALING;

EID: 84859992049     PISSN: 08985901     EISSN: 18847269     Source Type: Journal    
DOI: 10.5978/islsm.20.205     Document Type: Article

References (31)

1. Ohshiro T and Calderhead RG: Low Level Laser Therapy: a Practical Introduction. 1988. John Wiley and Sons, Chichester, UK.
2. Mester E, Szende B, Spiry T and Scher A (1972): Stimulation of wound healing by laser rays. Acta Chir Acad Sci Hung. 13: 315-324.
3. Calderhead RG, Ohshiro T, Ito E, Okada T and Kato K: The Nd:YAG and GaAlAs lasers: a comparative analysis in pain therapy. In Atsumi K and Nimsakul N, Eds: Laser Tokyo '81. 1981, Japan Society for Laser Surgery and Medicine, Tokyo. Section 21, pp 1-4.
4. Whelan HT, Houle JM, Whelan NT et al. (2000): The NASA Light-Emitting Diode Medical Program-Progress in Space Flight and Terrestrial Applications. Space Tech. & App. Int'l. Forum. 504: 37-43.
5. Calderhead RG (2007): The photobiological basics behind light-emitting diode (LED) phototherapy. Laser Therapy, 16: 97-108.
6. Smith KC (2005): Laser (and LED) therapy is phototherapy. Photomed Laser Surg. 23: 78-80.
7. Smith KC (2010): Laser and LED photobiology. Laser Therapy, 19: 72-78.
8. Whelan HT, Smits RL, Buchmann EV et al. (2001): Effect of NASA Light-Emitting Diode (LED) Irradiation on Wound Healing. J Clin Laser Med Surg, 2001. 19: 305-314.
9. Karu T (1999): Primary and secondary mechanisms of action of visible to near-IR radiation on cells. J Photochem Photobiol B, 49: 1-17.
10. Karu, T: Identification of the photoreceptors In: Karu T. Ten Lectures on Basic Science of Laser Phototherapy. 2007, Prima Books AB, Grangesberg, Sweden.
11. Tunér J and Hode L: The New Laser Therapy Handbook. 2010, Prima Press, Grangesborg, Sweden.
12. Gao X, Xing D. Molecular mechanisms of cell proliferation induced by low power laser irradiation. J Biomedical Science. 2009 16:4
13. Baxter GD, Bleakley C, Glasgow P, Calderhead RG (2005): A near-infrared LED-based rehabilitation system: initial clinical experience. Laser Therapy, 14: 29-36.
14. Moore KC, Hira N, Kumar PS, Jayakumar CS, and Ohshiro T (1988): A double blind crossover trial of low level laser therapy in the treatment of posther-petic neuralgia. Laser Therapy, Pilot Issue: 7-10.
15. Numazawa R, Kemmotsu O, Otsuka Hi, Kakehata J, Hashimoto T, and Tamagawa S (1996): The rôle of laser therapy in intensive pain management of postherpetic neuralgia. Laser Therapy, 8: 143-148.
16. Rochkind S (2009): Review of 30-years experience: laser phototherapy in neuroscience and neuro-surgery part II -nerve cells, brain and spinal cord. Laser Therapy, 18: 127-136.
17. Asanami S, Shiba H, Ohtaishi M, Okada Y, Ohshaka F, and Tanaka Y (1993): The activatory effect of low incident energy hene laser irradiation on hydroxyapatite implants in rabbit mandibular bone. Laser Therapy, 5: 29-32.
18. Calderhead RG, Kubota J, Trelles MA and Ohshiro T (2008): One mechanism behind LED phototherapy for wound healing and skin rejuvenation: key role of the mast cell. Laser Therapy, 17: 141-148.
19. Young S, Bolton P, Dyson M, Harvey W and Diamantopoulos C (1989): Macrophage responsiveness to light therapy. Lasers Surg Med, 9: 497-505.
20. Osanai T, Shiroto C, Mikami Y, Kudou E et al. (1990): Measurement of GaAlAs diode laser action on phagocytic activity of human neutrophils as a possible therapeutic dosimetry determinant. Laser Therapy, 1990. 2: 123-134.
21. Enwemeka CS, Cohen-Kornberg E, Duswalt EP, Weber DM, and Rodriguez IM (1994): Biomechanical effects of three different periods of GaAs laser photostimulation on tenotomized tendons. Laser Therapy, 6: 181-188.
22. Kubota J (2002): Effects of diode laser therapy on blood flow in axial pattern flaps in the rat model. Lasers Med Sci, 17: 146-153.
23. Goldberg DJ, Amin S, Russell BA, Phelps R et al.: Combined 633-nm and 830-nm led treatment of photoaging skin. J Drugs Dermatol, 2006. 5: 748-753.
24. Lee SY, Park KH, Choi JW, Kwon JK, et al.: A prospective, randomized, placebo-controlled, double-blinded, and split-face clinical study on LED phototherapy for skin rejuvenation: Clinical, pro-filometric, histologic, ultrastructural, and biochemical evaluations and comparison of three different treatment settings. J Photochem Photobiol (B), 2007. 88: 51-67 (available online as Epub ahead of print).
25. Mester E, Szende B, Gärtner P (1968): The effect of laser beams on the growth of hair in mice. Radiobiol Radiother (Berl). 9: 621-626
26. Waiz M, Saleh AZ, Hayani R, Jubory SO (2006): Use of the infrared diode laser (904 nm) in the treatment of alopecia areata. J Cosmet Laser Ther. 8: 27-30.
27. Shukla S, Sahu K, Verma Y, Rao KD, Dube A, Gupta PK (2010): Effect of helium-neon laser irradiation on hair follicle growth cycle of Swiss albino mice. Skin Pharmacol Physiol.; 23:79-85. Epub Dec 2009
28. Kim WS (2011): the systemic effect of 830 nm LED phototherapy on the wound healing of burn injuries: a controlled study in mouse and rat models. J Cos Laser Ther. In press.
29. Mester E, Mester AF, Mester A. (1985): The bio-medical effects of laser application. Lasers Surg Med. 5: 31-39.
30. Lee SY, You CE, and Park MY (2007): Blue and red light combination LED phototherapy for acne vul-garis in patients with skin phototype IV. Lasers Surg Med, 39: 180-188
31. Ablon G (2009): Combination 830-nm and 633-nm Light-Emitting Diode Phototherapy Shows Promise in the Treatment of Recalcitrant Psoriasis: Preliminary Findings. Photomed Laser Surg. 2009 Sep 21. [Epub ahead of print].