Isolation and characterization of lup-20(29)-ene-3, 28-diol (Betulin) from the stem-bark of Adenium obesum (Apocynaceae)

Tropical Journal of Pharmaceutical Research

Volumn 11, Issue 2, 2012, Pages 259-262

  Tijjani, A ^a   Ndukwe, I G ^a   Ayo, R G ^b  

^a AHMADU BELLO UNIVERSITY   (Nigeria)

^b Division of Agric College   (Nigeria)

Author keywords

28 diol; Adeniumobesum; Betulin; Isolation; Lup 20(29) ene 3; Stem bark

Indexed keywords

ADENIUM OBESUM EXTRACT; BETULIN; PLANT EXTRACT; UNCLASSIFIED DRUG;

ADENIUM OBESUM; APOCYNACEAE; ARTICLE; BARK; CARBON NUCLEAR MAGNETIC RESONANCE; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; CRYSTALLIZATION; DRUG DETERMINATION; DRUG STRUCTURE; HIGH TEMPERATURE PROCEDURES; ISOLATION PROCEDURE; MASS SPECTROMETRY; MELTING POINT; PHYTOCHEMISTRY; PLANT STEM; POWDER; PROTON NUCLEAR MAGNETIC RESONANCE; PURIFICATION; THIN LAYER CHROMATOGRAPHY;

EID: 84859980701     PISSN: 15965996     EISSN: 15969827     Source Type: Journal    
DOI: 10.4314/tjpr.v11i2.12     Document Type: Article

References (15)

1. Codd LE. Adenium obesum. The Flowering Plants of Africa. South African National Biodiversity Institute (SANBI), Pretoria, South Africa, 1987; 49: p 1953
2. Dimmitt MA, Hanson C. The genus Adenium in cultivation. Diplorhynchus Welw. ex Fic. &Hiern (Apocynaceae). Mededelingen, Cactus and Succulent. J., 1991; 63: 223-225
3. nd Edition, E. & S. Livingstone Ltd. Edinburgh and London, 1962; p 941
4. Neuwinger HD. African traditional medicine: a dictionary of plant use and applications. Medpharm Scientific, Stuttgart, Germany, 2000; p 589
5. Singh CU. Novel formulations of digitalis glycosides for treating cell-proliferative and other diseases. United States Patent Application 20040082521. U.S. Patent and Trademark Office, Alexandria VA, United States, 2004 [cited 2010 Mar 2]. Available from: www.freepatent.com
6. Graham JG, Quinn ML, Fabricant DS, Farnsworth NR. Plants used against cancer - an extension of the work of Jonathan Hartwell. J. Ethnopharm., 2000; 73: 347-377.
7. Stahl E, Kaltenbach PG. Antibody-dependent cellmediated cytotoxicity J. Chromatography, 1961; 5: 351-355.
8. Steenkamp V, Mathivha E, Gouws MC, van Rensburg CE. Studies on antibacterial, antioxidant and fibroblast growth stimulation of wound healing remedies from South Afr J. Ethnopharmacol, 2004; 95(2-3): 353-357.
9. 1H Chemical Shifts in Structural Investigations of Complex Natural Products. Tetrahedron, 1986; 42: 3419-3428.
10. Siddiqui S, Hafeez F, Begum S, Siddiqui B, Oleanderol S. A New Pentacyclic Triterpene from the Leaves of Nerium oleander. J. Nat. Prod., 1988; 51: 229-233.
11. 13C NMR Spectra of Pentacyclic Triterpenoids - A Compilation and Some Salient Features. Phytochemistry, 1994; 37: 1517-1575.
12. Biological properties of betulin [cited 2009 Dec 28]. Available from: http://www.betulin.ac/information-about-bitulin.htl/
13. Perumal Y and Dharmarajan S. Betulinic Acid and Its Derivatives: A Review on their Biological Properties.Curr Medicinal Chem, 2005;12:657-666.
14. Abdel-Monem A, Kadriya SE, Rwaida AA and Jaber SM. Phytochemical and Pharmacological Studies of Maytenus forsskaoliana. Saudi Pharm J, 2003; 11(4):184-191.
15. Robert HC and Samir AK. Chemistry, Biological Activity,and Chemotherapeutic Potential of Betulinic Acid for the Prevention and Treatment of Cancer and HIV Infection. Medicinal Res Rev, 2004; 24(1): 90-114