Therapy with rituximab for autoimmune pemphigus: Results from a single-center observational study on 42 cases with long-term follow-up

Journal of the American Academy of Dermatology

Volumn 67, Issue 4, 2012, Pages 617-622

  Cianchini, Giuseppe ^a   Lupi, Francesca ^a   Masini, Cinzia ^a   Corona, Rosamaria ^a   Puddu, Pietro ^a   De Pità, Ornella ^a  

^a LABORATORIO DI PATOLOGIA VASCOLARE   (Italy)

Author keywords

adverse events; autoimmune bullous diseases; B cell depleting treatment; immunosuppressive treatment; monoclonal antibodies; pemphigus; relapses; rituximab; therapy

Indexed keywords

BETAMETHASONE SODIUM PHOSPHATE; CHLORPHENIRAMINE MALEATE; PREDNISOLONE; PREDNISONE; RITUXIMAB;

ADJUVANT THERAPY; ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CORTICOSTEROID THERAPY; DRUG EFFICACY; DRUG TOLERABILITY; FEMALE; FOLLOW UP; HUMAN; INFECTION; LONG TERM CARE; MALE; OBSERVATIONAL STUDY; PEMPHIGUS; PNEUMOCYSTIS PNEUMONIA; PRIORITY JOURNAL; RELAPSE; REMISSION; TREATMENT DURATION; TREATMENT OUTCOME; TREATMENT RESPONSE;

ADULT; AGED; ANTIBODIES, MONOCLONAL, MURINE-DERIVED; DRUG THERAPY, COMBINATION; FEMALE; FOLLOW-UP STUDIES; GLUCOCORTICOIDS; HUMANS; IMMUNOLOGIC FACTORS; MALE; MIDDLE AGED; PEMPHIGUS; PREDNISONE; RECURRENCE; REMISSION INDUCTION; TREATMENT OUTCOME;

EID: 84859980675     PISSN: 01909622     EISSN: 10976787     Source Type: Journal    
DOI: 10.1016/j.jaad.2011.11.007     Document Type: Article

References (15)

1. J.C. Bystryn, and J.L. Rudolph Pemphigus Lancet 366 2005 61 73
2. D.F. Mutasim Management of autoimmune bullous diseases: pharmacology and therapeutics J Am Acad Dermatol 51 2004 859 877
3. L.K. Martin, V. Werth, E. Villanueva, J. Segall, and D.F. Murrell Interventions for pemphigus vulgaris and pemphigus foliaceous [review] Cochrane Database Syst Rev 1 2009 CD006263
4. A.R. Ahmed, Z. Spigelman, L.A. Cavacini, and M.R. Posner Treatment of pemphigus vulgaris with rituximab and intravenous immune globulin N Engl J Med 335 2006 1772 1779
5. P. Joly, H. Mouquet, J.C. Roujeau, M. D'Incan, D. Gilbert, and S. Jacquot A single cycle of rituximab for the treatment of severe pemphigus N Engl J Med 357 2007 545 552
6. G. Cianchini, R. Corona, A. Frezzolini, M. Ruffelli, B. Didona, and P. Puddu Treatment of severe pemphigus with rituximab: report of 12 cases and a review of the literature Arch Dermatol 143 2007 1033 1038
7. K.J. Allen, and S.E. Wolverton The efficacy and safety of rituximab in refractory pemphigus: a review of case reports J Drugs Dermatol 6 2007 883 889
8. P. Emery, R. Fleischmann, A. Filipowicz-Sosnowska, J. Schechtman, L. Szczepanski, and A. Kavanaugh The efficacy and safety of rituximab in patients with active rheumatoid arthritis despite methotrexate treatment: results of a phase IIB randomized, double-blind, placebo-controlled, dose-ranging trial Arthritis Rheum 54 2006 1390 1400
9. S.B. Cohen, P. Emery, M.W. Greenwald, M. Dougados, R.A. Furie, and M.C. Genovese Rituximab for rheumatoid arthritis refractory to anti-TNF therapy: results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks Arthritis Rheum 54 2006 2793 2806
10. D.F. Murrell, S. Dick, A.R. Ahmed, M. Amagai, M.A. Barnadas, and L. Borradori Consensus statement on definitions of disease, end points, and therapeutic response for pemphigus J Am Acad Dermatol 58 2008 1043 1046
11. S. Ikeda, S. Imamura, I. Hashimoto, S. Morioka, M. Sakuma, and H. Ogawa History of the establishment and revision of diagnostic criteria, severity index and therapeutic guidelines for pemphigus in Japan Arch Dermatol Res 295 Suppl 2003 S12 S16
12. J.A. Singh, G.A. Wells, R. Christensen, E. Tanjong Ghogomu, L. Maxwell, and J.K. Macdonald Adverse effects of biologics: a network meta-analysis and Cochrane overview Cochrane Database Syst Rev 2 2011 CD008794
13. E. Schmidt, M. Goebeler, and D. Zillikens Rituximab in severe pemphigus Ann N Y Acad Sci 1173 2009 683 691
14. R.J. Looney, R. Srinivasan, and L.H. Calabrese The effects of rituximab on immunocompetency in patients with autoimmune disease Arthritis Rheum 58 2008 5 14
15. M.C. Levesque, and E.W. St Clair B cell-directed therapies for autoimmune disease and correlates of disease response and relapse J Allergy Clin Immunol 121 2008 13 21