Potential mechanisms underlying the effect of gender on response to cardiac resynchronization therapy: Insights from the SMART-AV multicenter trial

Heart Rhythm

Volumn 9, Issue 5, 2012, Pages 736-741

  Cheng, Alan ^a   Gold, Michael R ^b   Waggoner, Alan D ^c   Meyer, Timothy E ^d   Seth, Milan ^d   Rapkin, Joshua ^d   Stein, Kenneth M ^d   Ellenbogen, Kenneth A ^e  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d BOSTON SCIENTIFIC CORPORATION   (United States)

^e VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

AV optimization; Cardiac resynchronization therapy; Congestive heart failure; Remodeling; Women

Indexed keywords

ADULT; AGED; ARTICLE; BODY MASS; CARDIAC RESYNCHRONIZATION THERAPY; CONTROLLED STUDY; DISEASE SEVERITY; ECHOCARDIOGRAPHY; FEMALE; HEART FAILURE; HEART LEFT BUNDLE BRANCH BLOCK; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE VOLUME; HUMAN; INCIDENCE; LINEAR REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY (TOPIC); NONISCHEMIC CARDIOMYOPATHY; PREDICTION; PRIORITY JOURNAL; QRS COMPLEX; SEX DIFFERENCE; TREATMENT RESPONSE;

BUNDLE-BRANCH BLOCK; CARDIAC RESYNCHRONIZATION THERAPY; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAPHY; FEMALE; HEART FAILURE, SYSTOLIC; HUMANS; MALE; QUESTIONNAIRES; SEX FACTORS; STROKE VOLUME; TREATMENT OUTCOME; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR REMODELING;

EID: 84859968698     PISSN: 15475271     EISSN: 15563871     Source Type: Journal    
DOI: 10.1016/j.hrthm.2011.12.013     Document Type: Article

References (16)

1. Ypenburg C, Westenberg JJ, Bleeker GB, et al. Noninvasive imaging in cardiac resynchronization therapy. Part 1: selection of patients. Pacing Clin Electrophysiol 2008;31:1475-1499.
2. Sutton MG, Plappert T, Hilpisch KE, Abraham WT, Hayes DL, Chinchoy E. Sustained reverse left ventricular structural remodeling with cardiac resynchronization at one year is a function of etiology: quantitative Doppler echocardiographic evidence from the Multicenter InSync Randomized Clinical Evaluation (MIRACLE). Circulation 2006;113:266-272.
3. Adelstein EC, Saba S. Usefulness of baseline electrocardiographic QRS complex pattern to predict response to cardiac resynchronization. Am J Cardiol 2009;103:238-242.
4. Bleeker BG, Schalij MJ, Boersma E, Steendijk P, Van Der Wall EE, Bax JJ. Does a gender difference in response to cardiac resynchronization therapy exist? Pacing Clin Electrophysiol 2005;28:1271-1275. (Pubitemid 43951386)
5. Zardkoohi O, Nandigam V, Murray L, et al. The impact of age and gender on cardiac resynchronization therapy outcome. Pacing Clin Electrophysiol 2007;30:1344-1348. (Pubitemid 350043825)
6. Arshad A, Moss AJ, Foster E, et al. Cardiac resynchronization therapy is more effective in women than in men: the MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy) Trial. J Am Coll Cardiol 2011;57:813-820.
7. Stein KM, Ellenbogen KA, Gold MR, et al. SmartDelay determined AV optimization. A comparison of AV delay methods used in cardiac resynchronization therapy (SMART-AV): rationale and design. Pacing Clin Electrophysiol 2010;33:54-63.
8. Ellenbogen KA, Gold MR, Meyer TE, et al. Primary results from the SmartDelay determined AV optimization: a comparison to other AV delay methods used in cardiac resynchronization therapy (SMART-AV) trial. Circulation 2010;122:2660-2668.
9. Saxon LA, Bristow MR, Boehmer J, et al. Predictors of sudden cardiac death and appropriate shock in the comparison of medical therapy, pacing and defibrillation in heart failure (COMPANION) trial. Circulation 2006;114:2766-2772. (Pubitemid 46018278)
10. Cleland JGF, Daubert JC, Erdmann E, et al. The effect of cardiac resynchronization on morbidity and mortality in heart failure. N Engl J Med 2005;352:1539-1549. (Pubitemid 40517094)
11. Linde C, Abraham WT, Gold MR, Daubert C. Cardiac resynchronization therapy in asymptomatic or mildy symptomatic heart failure patients in relation to etiology: results from the REVERSE (Resynchronization Reverses Remodeling in Systolic Left Ventricular Dysfunction) study. J Am Coll Cardiol 2010;56:1826-1831.
12. Tang ASL, Wells GA, Talajic M, et al. Cardiac-resynchronization therapy for mild-to-moderate heart failure. N Engl J Med 2010;363:2385-2395.
13. D'Andrea A, Scarafile R, Riegler L, et al. Right atrial size and deformation in patients with dilated cardiomyopathy undergoing cardiac resynchronization therapy. Eur J Heart Fail 2009;11:1169-1177.
14. Koplan BA, Kaplan AJ, Weiner S, Jones PS, Seth M, Christman SA. Heart failure decompensation and all-cause mortality in relation to percent biventricular pacing in patients with heart failure: is a goal of 100% biventricular pacing necessary? J Am Coll Cardiol 2009;53:355-360.
15. Hayes DL, Boehmer JP, Day J, et al. Cardiac resynchronization therapy and the relationship of percent biventricular pacing to symptoms and survival. Heart Rhythm 2011;8:1469-1475.
16. Mooyaart EAQ, Marsan NA, van Bommel RJ, et al. Comparison of long-term survival of men versus women with heart failure treated with cardiac resynchronization therapy. Am J Cardiol 2011;108:63-68.