Association between the rs1050450 glutathione peroxidase-1 (C > T) gene variant and peripheral neuropathy in two independent samples of subjects with diabetes mellitus

Nutrition, Metabolism and Cardiovascular Diseases

Volumn 22, Issue 5, 2012, Pages 417-425

  Tang, T S ^a   Prior, S L ^a   Li, K W ^b   Ireland, H A ^b   Bain, S C ^a   Hurel, S J ^c   Cooper, J A ^b   Humphries, S E ^b   Stephens, J W ^a  

^a SWANSEA UNIVERSITY   (United Kingdom)

^b ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON HOSPITALS   (United Kingdom)

Author keywords

Diabetes; Glutathione peroxidase; Oxidative stress; Peripheral neuropathy; Total anti oxidant status

Indexed keywords

ANTIOXIDANT; BIOLOGICAL MARKER; GLUTATHIONE PEROXIDASE; GLUTATHIONE PEROXIDASE 1; LOW DENSITY LIPOPROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN;

AGED; ALLELE; ARTICLE; BLOOD; CASE CONTROL STUDY; CAUCASIAN; CLINICAL TRIAL; CROSS-SECTIONAL STUDY; DIABETIC NEUROPATHY; ETHNOLOGY; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETICS; HUMAN; MALE; METABOLISM; MIDDLE AGED; MULTICENTER STUDY; OXIDATIVE STRESS; SINGLE NUCLEOTIDE POLYMORPHISM; UNITED KINGDOM;

AGED; ALLELES; ANTIOXIDANTS; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CROSS-SECTIONAL STUDIES; DIABETIC NEUROPATHIES; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GLUTATHIONE PEROXIDASE; HUMANS; LIPOPROTEINS, LDL; LONDON; MALE; MIDDLE AGED; OXIDATIVE STRESS; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84859945567     PISSN: 09394753     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.numecd.2010.08.001     Document Type: Article

References (35)

1. Thomas P.K. Diabetic peripheral neuropathies: their cost to patient and society and the value of knowledge of risk factors for development of interventions. Eur Neurol 1999, 1(41 Suppl.):35-43.
2. Boulton A.J., Gries F.A., Jervell J.A. Guidelines for the diagnosis and outpatient management of diabetic peripheral neuropathy. Diabet Med 1998, 15:508-514.
3. Group TDCaCTR The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993, 329:977-986.
4. Bedlack R.S., Edelman D., Gibbs J.W., Kelling D., Strittmatter W., Saunders A.M., et al. APOE genotype is a risk factor for neuropathy severity in diabetic patients. Neurology 2003, 60:1022-1024.
5. Stephens J.W., Gable D.R., Hurel S.J., Miller G.J., Cooper J.A., Humphries S.E. Increased plasma markers of oxidative stress are associated with coronary heart disease in males with diabetes mellitus and with 10-year risk in a prospective sample of males. Clin Chem 2006, 52:446-452.
6. Kopprasch S., Pietzsch J., Kuhlisch E., Fuecker K., Temelkova-Kurktschiev T., Hanefeld M., et al. In vivo evidence for increased oxidation of circulating LDL in impaired glucose tolerance. Diabetes 2002, 51:3102-3106.
7. Beckett G.J., Arthur J.R. Selenium and endocrine systems. J Endocrinol 2005, 184:455-465.
8. Forgione M.A., Weiss N., Heydrick S., Cap A., Klings E.S., Bierl C., et al. Cellular glutathione peroxidase deficiency and endothelial dysfunction. Am J Physiol Heart Circ Physiol 2002, 282:H1255-H1261.
9. Espinola-Klein C., Rupprecht H.J., Bickel C., Schnabel R., Genth-Zotz S., Torzewski M., et al. Glutathione peroxidase-1 activity, atherosclerotic burden, and cardiovascular prognosis. Am J Cardiol 2007, 99:808-812.
10. Blankenberg S., Rupprecht H.J., Bickel C., Torzewski M., Hafner G., Tiret L., et al. Glutathione peroxidase 1 activity and cardiovascular events in patients with coronary artery disease. N Engl J Med 2003, 349:1605-1613.
11. Sun D.Q., Li A.W., Li J., Li D.G., Li Y.X., Hao F., et al. Changes of lipid peroxidation in carbon disulfide-treated rat nerve tissues and serum. Chem Biol Interact 2009, 179:110-117.
12. Kishi Y., Nickander K.K., Schmelzer J.D., Low P.A. Gene expression of antioxidant enzymes in experimental diabetic neuropathy. J Peripher Nerv Syst 2000, 5:11-18.
13. Martinez-Blasco A., Bosch-Morell F., Trenor C., Romero F.J. Experimental diabetic neuropathy: role of oxidative stress and mechanisms involved. Biofactors 1998, 8:41-43.
14. Rosenblat M., Aviram M. Macrophage glutathione content and glutathione peroxidase activity are inversely related to cell-mediated oxidation of LDL: in vitro and in vivo studies. Free Radic Biol Med 1998, 24:305-317.
15. Guo Z., Van Remmen H., Yang H., Chen X., Mele J., Vijg J., et al. Changes in expression of antioxidant enzymes affect cell-mediated LDL oxidation and oxidized LDL-induced apoptosis in mouse aortic cells. Arterioscler Thromb Vasc Biol 2001, 21:1131-1138.
16. Ravn-Haren G., Olsen A., Tjonneland A., Dragsted L.O., Nexo B.A., Wallin H., et al. Associations between GPX1 Pro198Leu polymorphism, erythrocyte GPX activity, alcohol consumption and breast cancer risk in a prospective cohort study. Carcinogenesis 2006, 27:820-825.
17. Hamanishi T., Furuta H., Kato H., Doi A., Tamai M., Shimomura H., et al. Functional variants in the glutathione peroxidase-1 (GPx-1) gene are associated with increased intima-media thickness of carotid arteries and risk of macrovascular diseases in Japanese type 2 diabetic patients. Diabetes 2004, 53:2455-2460.
18. Tang N.P., Wang L.S., Yang L., Gu H.J., Sun Q.M., Cong R.H., et al. Genetic variant in glutathione peroxidase 1 gene is associated with an increased risk of coronary artery disease in a Chinese population. Clin Chim Acta 2008, 395:89-93.
19. Kuzuya M., Ando F., Iguchi A., Shimokata H. Glutathione peroxidase 1 Pro198Leu variant contributes to the metabolic syndrome in men in a large Japanese cohort. Am J Clin Nutr 2008, 87:1939-1944.
20. Mir O., Alexandre J., Tran A., Durand J.P., Pons G., Treluyer J.M., et al. Relationship between GSTP1 Ile(105)Val polymorphism and docetaxel-induced peripheral neuropathy: clinical evidence of a role of oxidative stress in taxane toxicity. Ann Oncol 2009, 20:736-740.
21. Chistiakov D.A., Zotova E.V., Savost'anov K.V., Bursa T.R., Galeev I.V., Strokov I.A., et al. The 262T > C promoter polymorphism of the catalase gene is associated with diabetic neuropathy in type 1 diabetic Russian patients. Diabete Metab 2006, 32:63-68.
22. Dhamrait S.S., Stephens J.W., Cooper J.A., Acharya J., Mani A.R., Moore K., et al. Cardiovascular risk in healthy men and markers of oxidative stress in diabetic men are associated with common variation in the gene for uncoupling protein 2. Eur Heart J 2004, 25:468-475.
23. Stephens J.W., Dhamrait S.S., Acharya J., Humphries S.E., Hurel S.J. A common variant in the ACE gene is associated with peripheral neuropathy in women with type 2 diabetes mellitus. J Diabet Complications 2006, 20:317-321.
24. Alberti K.G., Zimmet P.Z. New diagnostic criteria and classification of diabetes - again?. Diabet Med 1998, 15:535-536.
25. American Diabetes Association, Neurology AAo Report and recommendations of the San Antonio conference on diabetic neuropathy. Diabetes Care 1998, 11:592-597.
26. Sampson M.J., Gopaul N., Davies I.R., Hughes D.A., Carrier M.J. Plasma F2 isoprostanes: direct evidence of increased free radical damage during acute hyperglycemia in type 2 diabetes. Diabetes Care 2002, 25:537-541.
27. Scheffer P.G., Bos G., Volwater H.G., Dekker J.M., Heine R.J., Teerlink T. Associations of LDL size with in vitro oxidizability and plasma levels of in vivo oxidized LDL in Type 2 diabetic patients. Diabet Med 2003, 20:563-567.
28. Rothman K.J. No adjustments are needed for multiple comparisons. Epidemiology 1990, 1:43-46.
29. Raaschou-Nielsen O., Sorensen M., Hansen R.D., Frederiksen K., Tjonneland A., Overvad K., et al. GPX1 Pro198Leu polymorphism, interactions with smoking and alcohol consumption, and risk for lung cancer. Cancer Lett 2007, 247:293-300.
30. Steinbrecher U.P., Parthasarathy S., Leake D.S., Witztum J.L., Steinberg D. Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids. Proc Natl Acad Sci U S A 1984, 81:3883-3887.
31. Said G., Lacroix C., Lozeron P., Ropert A., Plante V., Adams D. Inflammatory vasculopathy in multifocal diabetic neuropathy. Brain 2003, 126:376-385.
32. Tsuzura S., Ikeda Y., Suehiro T., Ota K., Osaki F., Arii K., et al. Correlation of plasma oxidized low-density lipoprotein levels to vascular complications and human serum paraoxonase in patients with type 2 diabetes. Metabolism 2004, 53:297-302.
33. Sobal G., Menzel J.E., Sinzinger H. Influence of acetylsalicylic acid on oxidation of native and glycated low-density lipoprotein. Life Sci 2000, 66:1987-1998.
34. Galland F., Duvillard L., Petit J.M., Lagrost L., Vaillant G., Brun J.M., et al. Effect of insulin treatment on plasma oxidized LDL/LDL-cholesterol ratio in type 2 diabetic patients. Diabete Metab 2006, 32:625-631.
35. Risch N.J. Searching for genetic determinants in the new millennium. Nature 2000, 405:847-856.