Gene variants in the folate-mediated one-carbon metabolism (FOCM) pathway as risk factors for conotruncal heart defects

American Journal of Medical Genetics, Part A

Volumn 158 A, Issue 5, 2012, Pages 1124-1134

  Zhu, Huiping ^a   Yang, Wei ^b   Lu, Wei ^c   Etheredge, Analee J ^d   Lammer, Edward J ^e   Finnell, Richard H ^a   Carmichael, Suzan L ^b   Shaw, Gary M ^b  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF TEXAS SCHOOL OF PUBLIC HEALTH   (United States)

^e CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

Author keywords

Conotruncal defects; DHFR; Folate; MTHFD1; MTHFR; One carbon metabolism; SHMT1

Indexed keywords

GENOMIC DNA;

ADOLESCENT; ADULT; ARTICLE; CAUCASIAN; CONGENITAL HEART MALFORMATION; CONOTRUNCAL HEART DEFECT; CONTROLLED STUDY; DIHYDROFOLATE REDUCTASE GENE; DISEASE ASSOCIATION; FALLOT TETRALOGY; FEMALE; FOLATE INTAKE; FOLATE MEDIATED ONE CARBON METABOLISM PATHWAY; FOLATE METABOLISM; GENE; GENE INTERACTION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GREAT VESSELS TRANSPOSITION; HAPLOTYPE; HETEROZYGOTE; HISPANIC; HOMOZYGOTE; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; MATERNAL NUTRITION; METHYLENE TETRAHYDROFOLATE DEHYDROGENASE 1 GENE; METHYLENETETRAHYDROFOLATE REDUCTASE GENE; POPULATION BASED CASE CONTROL STUDY; PRIORITY JOURNAL; SERINE HYDROXYL METHYLTRANSFERASE 1 GENE; SINGLE NUCLEOTIDE POLYMORPHISM; THYMIDYLATE SYNTHASE GENE; VITAMIN INTAKE; VITAMIN SUPPLEMENTATION; WILD TYPE;

CARBON; FEMALE; FOLIC ACID; GENOTYPE; HEART DEFECTS, CONGENITAL; HISPANIC AMERICANS; HUMANS; METABOLIC NETWORKS AND PATHWAYS; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); ODDS RATIO; POLYMORPHISM, GENETIC; RISK FACTORS;

EID: 84859944126     PISSN: 15524825     EISSN: 15524833     Source Type: Journal    
DOI: 10.1002/ajmg.a.35313     Document Type: Article

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