Effect of Terminalia chebula Retz on den induced hepatocellular carcinogenesis in experimental rats

International Journal of Pharmacy and Pharmaceutical Sciences

Volumn 4, Issue 2, 2012, Pages 440-445

  Srigopalram, Srisesharam ^a   Jayraaj, Indira A ^a  

^a KONGUNADU ARTS AND SCIENCE COLLEGE   (India)

Author keywords

Antioxidants; DEN; T.chebula; Transmission electron microscope

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CATALASE; DIETHYLNITROSAMINE; GAMMA GLUTAMYL HYDROLASE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; LACTATE DEHYDROGENASE; SUPEROXIDE DISMUTASE; TERMINALIA CHEBULA EXTRACT; TUMOR MARKER; WATER;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL STRUCTURE; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; HISTOPATHOLOGY; LACTATE DEHYDROGENASE BLOOD LEVEL; LIPID PEROXIDATION; LIVER CANCER; LIVER CARCINOGENESIS; MALE; NONHUMAN; RAT; SOLVENT EXTRACTION; TERMINALIA CHEBULA; TRANSMISSION ELECTRON MICROSCOPY;

EID: 84859941902     PISSN: None     EISSN: 09751491     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Fabry W, Okemo PO, Ansorg R. Antibacterial activity of East African medicinal plants. Journal of Ethnopharmacology 1998; 60: 79-84.
2. Barthakur NN, Arnold NP. Nutritive value of the chebulinic myrobalan (Terminalia chebula Retz.) and its potential as a food source. Food Chemistry 1991; 40: 213-219.
3. Singh C. 2a-hydroxy micromeric acid,a pentacyclic triterpene from Terminalia chebula. Phytochemistry 1990; 29: 2348-2350.
4. Chattopadhyay RR, Bhattacharyya SK. Terminalia chebula: an update. Pharmacognosy Reviews 2007; 1: 151-156. 5.
5. Ribes J, Cleries R, Esteban L, Moreno V, Bosch FX. The influence of alcohol consumption and hepatitisB and C infections on the risk of liver cancer in Europe. J.Hepatol 2008; 49: 233-242.
6. Parkin DM, Bray F, Ferlay J, Pisani P. Estimating the world cancer burden: Globoscan 2000. Int.J.Cancer 2000; 94: 153-156.
7. Alessandro ND, Poma P, Montalto G. Multifactorial nature of hepatocellular carcinoma drug resistance: could plant polyphenols be helpful?. World J Gastroenterol 2007; 13: 2037-2043.
8. Peto R, Gary R, Brantom P, Grasso P. Dose and time relationships for tumor induction in the liver and esophagus of 4080 inbred rats by chronic ingestion of Nnitrosodiethylamine or N- nitrosomethylamine. Cancer Res 1991; 51: 6452-6469.
9. Marnett LJ. Oxyradicals and DNA damage. Carcinogenesis 2000; 21: 361-70.
10. Hristozov D, Gadjeva V, Vlaykova T, Dimitrov G. Evaluation of oxidative stress in patients with cancer. Arch Physiol Biochem 2001; 109: 331-6.
11. Ray G, Batra S, Shukla NK, Deo S, Raina V, Ashok S, et al. Lipid peroxidation, free radical production and antioxidant status in breast cancer. Breast Cancer Res Treat 2000; 59: 163-70.
12. Cotgreave I, Moldens P, Orrenius S. Host biochemical defence mechanisms against prooxidants. Annu Rev Pharmacol Toxicol 1988;28:189-212.
13. Czinner E, Hagymasi K, Blazovics A, Kery A, Szoke E, Lemberkovics E. The In vitro effect of Helichrysi flos on microsomal lipid peroxidation. J Ethanopharmacol 2001; 77: 31-5.
14. Jagetia GC, Rao SK. Evaluation of the antineoplastic activity of guduchi (Tinospora cordifolia) in Ehrlich ascites carcinoma bearing mice. Biol Pharm Bull 2006; 29: 460-6.
15. Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radical and antioxidants in normal physiological functions and humandisease. Int.J. Biochem.CellBiol 2007; 39: 44-84.
16. Bartsch H, Nair J. Chronic inflammation and oxidative stress in the genesis and perpetuation of cancer: role of lipid peroxidation, DNA damage, and repair. Langenbecks Arch. Surg 2006; 391: 499-510.
17. Jeena KJ, Joy KL, Kuttan R. Effect of Emblica officinalis, Phyllanthus amarus and Picrorrhiza kurroa on Nnitrosodiethylamine induced hepatocarcinogenesis. CancerLett 1999; 136: 11-16.
18. Archer MC. Mechanisms of action on N-nitroso compounds. Cancer. Surv 1989; 8: 241-250.
19. Brown JL. N-Nitrosamines. Occup. Med 1999; 14: 839-848.
20. Mittal G, Brar AP, Soni G. Impact of hypercholesterolemia on toxicity of N- nitrosodiethylamine: biochemical and histopathological effects. Pharmacol. Rep 2006; 58: 413-419.
21. Sivaramakrishnan V, Devaraj SN. Morin regulates the expression of NF-k B-p65, COX-2 and Matrix metalloproteinases in diethylnitrosamine induced rat hepatocellular carcinoma. Chem. Biol. Inter 2009; 180: 353-359.
22. Ohkawa H, Ohishi N, Yagi K. Assay of lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979; 95: 351-8.
23. King J. The transferases-alanine and aspartate transaminases, in: D. Van (Ed.), In Practical Clinical Enzymology. Nostrand Company Ltd, London 1965a pp. 191-208, pp. 121-128.
24. King J. The hydrolases-acid and alkaline phosphatases, in: D. Van (Ed.), In Practical Clinical Enzymology. Nostrand Company Ltd, London 1965b pp. 191-208.
25. King J. The dehydrogenases or oxidoreductase-lactate dehydrogenase, in: D. Van (Ed.), In Practical Clinical Enzymology. Nostrand Company Ltd, London 1965c; pp: 83-93, pp: 121-128.
26. Rosali SB, Rau D, Serum gamma-glutamyl transpeptidase activity in alcoholism. Clin. Chim. Acta. 1972; 39: 41-47.
27. Luly P, Barnabei O, Tria E. Hormonal control in vitro of plasma membrane bound Na+, K+-ATPase of rat liver. Biochim Biophys Acta 1972; 282: 447-52.
28. Misra HP, Fridovich I. The role of superoxide anion in the antioxidation of epinephrine and a simple assay for superoxide dismutase. J. Biol. Chem 1972; 247: 3170-3175.
29. Sinha AK. Colorimetric assay of catalase. Anal. Biochem 1972; 47: 380-395.
30. Rotruck J, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WGO. Selenium, biochemical role as a component of glutathione peroxidase purification and assay. Science 1973; 179: 588-590.
31. Habig WH, Pabst MJ, Jakoby WB. Glutathione-S-transferase. The first enzymatic step in mercapturic acid formation. J. Biol. Chem 1974; 249: 71130-71139.
32. Maron MS, Die fierre JW, Mannervik KB. Levels of glutathione, glutathione reductase and glutathione-S-transferase activities in rat lung and liver. Biochem. Biophys. Acta 1979c; 582: 67-78.
33. Sell S, Beckar FF. Alphafetoprotein. Natl.CancerInst 1978; 60: 19-26.
34. Macnab GM, Urbanowicz JM, Kew MC. Carcinoembryonic antigen in hepatocellular cancer. Br.J.Cancer 1978; 38: 51-54.
35. Mori M. Electron microscopic and new microscopic studies of hepatocyte cytoskeleton.physiological and pathological relevance. J. Electron Microsc 1994; 43: 347-355.
36. Esterbauer H, Zollner H, Schaua RJ. Aldehydes formed by lipid peroxidation: mechanisms of formation, occurrences and determination. In: Vigo-Pelfrey C, editor. Membrance lipid peroxidation. Boca Raton CRC 1990; p: 239-83.
37. Seckin S, Neclakocak-Toker N, Usal M, Buge O. The role of lipid peroxidation and calcium in galactosamine induced toxicity in the rat liver. Res Comm Chem Pathol Pharmacol 1993; 80: 117-20.
38. Sell S, Becker F, Leffert HL, sborn KO, Salman J, ombardi BL, Shinozuka H, Reddy J, oushlahti ER, Sala-Trepat J. α -Fetoprotein as a marker for early events and carcinoma development during chemical hepatocarcinogenesis. Environ.Sci.Res 1983; 29: 271-293.
39. Becker FF, Sell S. Differences in serum α -fetoprotein concentrations during the carcinogenic sequences resulting from exposure to diethylnitrosamine or acetaminofluorene. Cancer.Res 1979; 39: 1437-1442.
40. Zimmer R, Thomas P. Mutations in the carcinoembryonic antigen gene in colorectal cancer patients: implications on liver metastasis. Cancer.Res 2001; 61: 2822-2826.
41. Mc-Intrye N, Rosalki S. Biochemical investigation in the management of liver diseases. In: Prieto J, Rodes J, Shafritz DA, editors. Hepatobiliary Diseases. Berlin:Springer-Verlag 1992. p. 39-71.
42. Kamdem L, Siest G, Magdalou J. Differential toxicity of aflotoxin B1 in male and female rats relationship with hepatic drug metabolizing enzymes. Biochem Pharmacol 1982; 31: 3057-62.
43. Sallie R, Fredger JM, William R. Immunohistochemical study of proteoglycans in D- galactosamne induced acute liver injury in rats. J Gastroentrol 1991; 31: 46-54.
44. Robak J, Glyglewsi RJ. Flavonoids are scavengers of superoxide anions. Biochem.Pharmacol 1988; 37: 837-841
45. Ketterer B, Meyer DJ. Glutathione transferases: a possible role in the detoxification and repair of DNA and lipid hydroperoxides. Mutat.Res 1989; 45: 1-8.
46. Batko J, Warchol T, Karon H. The activities of super oxide dismutase, catalase, glutathione peroxidase and glutathione reductase in erythrocytes of rats with experimental neoplastic diseases. Acta. Biochim. Pol 1996; 43: 403-405.