LYVE-1 upregulation and lymphatic invasion correlate with adverse prognostic factors and lymph node metastasis in neuroblastoma

Virchows Archiv

Volumn 460, Issue 2, 2012, Pages 183-191

  Ramani, Pramila ^a,b   Dungwa, Josiah V ^a,b   May, Margaret T ^b  

^a BRISTOL ROYAL INFIRMARY   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Lymph node metastasis; Lymphatic density; Lymphatic invasion; LYVE 1; Neuroblastoma

Indexed keywords

BIOLOGICAL MARKER; PROTEIN LYVE 1; UNCLASSIFIED DRUG; LYVE1 PROTEIN, HUMAN; TUMOR MARKER; VESICULAR TRANSPORT PROTEIN;

ARTICLE; CANCER INVASION; CANCER PROGNOSIS; CANCER RISK; CANCER STAGING; CORRELATION ANALYSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; LYMPH VESSEL; MAJOR CLINICAL STUDY; NEUROBLASTOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSITIVITY ANALYSIS; SURVIVAL RATE; UPREGULATION; ADOLESCENT; BIOSYNTHESIS; CHILD; INFANT; KAPLAN MEIER METHOD; METABOLISM; MORTALITY; NEWBORN; PATHOLOGY; PRESCHOOL CHILD; PROGNOSIS; PROPORTIONAL HAZARDS MODEL;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNOHISTOCHEMISTRY; INFANT; INFANT, NEWBORN; KAPLAN-MEIER ESTIMATE; LYMPHATIC METASTASIS; LYMPHATIC VESSELS; NEOPLASM STAGING; NEUROBLASTOMA; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION; VESICULAR TRANSPORT PROTEINS;

EID: 84859936291     PISSN: 09456317     EISSN: 14322307     Source Type: Journal    
DOI: 10.1007/s00428-011-1190-y     Document Type: Article

References (20)

1. Maris JM, Hogarty MD, Bagatell R et al (2007) Neuroblastoma. Lancet 369:2106-2120 (Pubitemid 46935947)
2. Cohn SL, Pearson AD, London WB et al (2009) The International Neuroblastoma Risk Group (INRG) classification system: an INRG Task Force report. J Clin Oncol 27:289-297
3. Shimada H, Ambros IM, Dehner LP et al (1999) The International Neuroblastoma Pathology Classification (the Shimada system). Cancer 86:364-372 (Pubitemid 29327594)
4. Rossler J, Taylor M, Geoerger B et al (2008) Angiogenesis as a target in neuroblastoma. Eur J Cancer 44:1645-1656
5. Lagodny J, Juttner E, Kayser G et al (2007) Lymphangiogenesis and its regulation in human neuroblastoma. Biochem Biophys Res Commun 352:571-577 (Pubitemid 44838525)
6. Ribatti D, Nico B, Cimpean AM et al (2010) Podoplanin and LYVE-1 expression in lymphatic vessels of human neuroblastoma. J Neurooncol 100:151-152
7. Becker J, Wang B, Pavlakovic H et al (2010) Homeobox transcription factor Prox1 in sympathetic ganglia of vertebrate embryos: correlation with human stage 4 s neuroblastoma. Pediatr Res 68:112-117
8. Becker J, Pavlakovic H, Ludewig F et al (2010) Neuroblastoma progression correlates with downregulation of the lymphangiogenesis inhibitor sVEGFR-2. Clin Cancer Res 16:1431-1441
9. Eggert A, Ikegaki N, Kwiatkowski J et al (2000) High-level expression of angiogenic factors is associated with advanced tumor stage in human neuroblastomas. Clin Cancer Res 6:1900-1908 (Pubitemid 30305088)
10. Komuro H, Kaneko S, Kaneko M et al (2001) Expression of angiogenic factors and tumor progression in human neuroblastoma. J Cancer Res Clin Oncol 127:739-743 (Pubitemid 33079374)
11. Nowicki M, Konwerska A, Ostalska-Nowicka D et al (2008) Vascular endothelial growth factor (VEGF)-C-a potent risk factor in children diagnosed with stadium 4 neuroblastoma. Folia Histochem Cytobiol 46:493-499
12. Sleeman JP, Thiele W (2009) Tumor metastasis and the lymphatic vasculature. Int J Cancer 125:2747-2756
13. Baluk P, McDonald DM (2008) Markers for microscopic imaging of lymphangiogenesis and angiogenesis. Ann N Y Acad Sci 1131:1-12 (Pubitemid 351758499)
14. Van der Auwera I, Cao Y, Tille JC et al (2006) First international consensus on the methodology of lymphangiogenesis quantification in solid human tumours. Br J Cancer 95:1611-1625 (Pubitemid 44950785)
15. Beasley NJ, Prevo R, Banerji S et al (2002) Intratumoral lymphangiogenesis and lymph node metastasis in head and neck cancer. Cancer Res 62:1315-1320 (Pubitemid 34407785)
16. Van der Auwera I, Van den Eynden GG, Colpaert CG et al (2005) Tumor lymphangiogenesis in inflammatory breast carcinoma: a histomorphometric study. Clin Cancer Res 11:7637-7642 (Pubitemid 41611604)
17. Maris JM (2010) Recent advances in neuroblastoma. N Engl J Med 362:2202-2211
18. Gombos Z, Xu X, Chu CS et al (2005) Peritumoral lymphatic vessel density and vascular endothelial growth factor C expression in early-stage squamous cell carcinoma of the uterine cervix. Clin Cancer Res 11:8364-8371 (Pubitemid 41746949)
19. Straume O, Jackson DG, Akslen LA (2003) Independent prognostic impact of lymphatic vessel density and presence of low-grade lymphangiogenesis in cutaneous melanoma. Clin Cancer Res 9:250-256 (Pubitemid 36109741)
20. Dadras SS, Paul T, Bertoncini J et al (2003) Tumor lymphangiogenesis: a novel prognostic indicator for cutaneous melanoma metastasis and survival. Am J Pathol 162:1951-1960 (Pubitemid 36613052)