"Atypical femoral fractures" during bisphosphonate exposure in adult hypophosphatasia

Journal of Bone and Mineral Research

Volumn 27, Issue 5, 2012, Pages 987-994

  Sutton, Roger A L ^a   Mumm, Steven ^b,c   Coburn, Stephen P ^d   Ericson, Karen L ^d   Whyte, Michael P ^b,c  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b SHRINERS HOSPITAL FOR CHILDREN   (United States)

^c BARNES JEWISH HOSPITAL   (United States)

^d INDIANA UNIVERSITY PURDUE UNIVERSITY FORT WAYNE   (United States)

Author keywords

ALENDRONATE; ALKALINE PHOSPHATASE; ANTIRESORPTIVES; OSTEOMALACIA; OSTEOPOROSIS; PSEUDOFRACTURE; PYRIDOXAL PHOSPHATE; PYROPHOSPHATE; STRESS FRACTURE; VITAMIN B 6; ZOLENDRONATE

Indexed keywords

ALENDRONIC ACID; ALKALINE PHOSPHATASE; CALCIUM; COLECALCIFEROL; RADIOISOTOPE; ZOLEDRONIC ACID;

ADULT; ALKALINE PHOSPHATASE BLOOD LEVEL; ANKLE PAIN; ARTICLE; BONE DENSITY; BONE SCINTISCANNING; BURSITIS; CASE REPORT; DRUG EXPOSURE; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FEMUR FRACTURE; HUMAN; HYPOPHOSPHATASIA; MENOPAUSE; MERALGIA PARESTHETICA; METATARSAL STRESS FRACTURE; OSTEOSYNTHESIS; PERIOSTITIS; PLATE FIXATION; SWELLING; WRIST FRACTURE;

ALENDRONATE; DIPHOSPHONATES; FEMALE; FEMORAL FRACTURES; HUMANS; HYPOPHOSPHATASIA; IMIDAZOLES; MIDDLE AGED;

EID: 84859907817     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.1565     Document Type: Article

References (38)

1. Khandwala HM, Mumm S, Whyte MP., Low serum alkaline phosphatase activity and pathologic fracture: case report and brief review of hypophosphatasia diagnosed in adulthood. Endocr Pract. 2006; 12: 676-81.
2. Hardy DC, Murphy WA, Siegel BA, Reid IR, Whyte MP., X-linked hypophosphatemia in adults: prevalence of skeletal radiographic and scintigraphic features. Radiology. 1989; 171: 403-14.
3. Shane E, Burr D, Ebeling PR, et al. Atypical subtrochanteric and diaphyseal femoral fractures: report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res. 2010; 25: 1-28.
4. Park-Wyllie LY, Mamdani MM, Juurlink DN, et al. Bisphosphonate use and the risk of subtrochanteric or femoral shaft fractures in older women. JAMA. 2011; 305: 783-9.
5. Schilcher J, Michaelsson K, Aspenberg P., Bisphosphonate use and atypical fractures of the femoral shaft. N Engl J Med. 2011; 364: 1728-37.
6. Amit S, Shehkar A, Vivek M, Shekhar S, Biren N., Fixation of subtrochanteric fractures in two patients with osteopetrosis using a distal femoral locking compression plate of the contralateral side. Eur J Trauma Emerg Surg. 2010; 36: 263-9.
7. Birmingham P, McHale KA., Case reports: treatment of subtrochanteric and ipsilateral femoral neck fractures in an adult with osteopetrosis. Clin Orthop Rel Res. 2008; 466: 2002-8.
8. Yates JY, Bartlett MJ, Ebeling PR., An atypical subtrochanteric femoral fracture from pycnodysostosis: a lesson from nature. J Bone Miner Res. 2011; 26: 1377-9.
9. Whyte MP., Hypophosphatasia. In:, Glorieux FH, Jueppner H, Pettifor J, editors. Pediatric bone: biology and diseases. 3rd edition. San Diego, CA: Elsevier; 2012. p. 771-94.
10. Fleisch H, Russell RGG, Francis MD., Diphosphonates inhibit hydroxyapatite dissolution in vitro and bone resorption in tissue culture and in vivo. Science. 1969; 165: 1262-4.
11. Whyte MP., Physiological role of alkaline phosphatase explored in hypophosphatasia. Ann N Y Acad Sci. 2010; 1192: 190-200.
12. Chodirker BN, Coburn SP, Seargeant LE, Whyte MP, Greenberg CR., Increased plasma pyridoxa1-5'-phosphate levels before and after pyridoxine loading in carriers of perinatal/infantile hypophosphatasia. J Inherit Metab Dis. 1990; 13: 891-6.
13. Coe JD, Murphy WA, Whyte M., Management of femoral fractures and pseudofractures in adult hypophosphatasia. J Bone Joint Surg. 1986; 68A: 981-90.
14. Whyte MP, Mumm S, Deal C., Adult hypophosphatasia treated with teriparatide. J Clin Endocrinol Metab. 2007; 92: 1203-8.
15. Doshi KB, Hamrahian AH, Licata AA., Teriparatide treatment in adult hypophosphatasia in a patient exposed to bisphosphonate: a case report. Clin Cases Miner Bone Metab. 2009; 3: 266-9.
16. Ericson KL, Mahuren JD, Zubovic YM, Coburn SP., Use of chlorite to improve HPLC detection of pyridoxal 5'-phosphate. J Chromatogr B Analyt Technol Biomed Life Sci. 2005; 823: 218-20.
17. Mumm S, Jones J, Finnegan P, Henthorn PS, Podgornik MN, Whyte MP., Denaturing gradient gel electrophoresis analysis of the tissue nonspecific alkaline phosphatase isoenzyme gene in hypophosphatasia. Mol Genet Metab. 2002; 75: 143-53.
18. Fallon MD, Weinstein RS, Goldfischer S, Brown DS, Whyte MP., Hypophosphatasia: clinicopathologic comparison of the infantile, childhood, and adult forms. Medicine (Baltimore). 1984; 63: 12-24.
19. Weinstein RS, Whyte MP., Heterogeneity of adult hypophosphatasia. Report of severe and mild cases. Arch Intern Med. 1981; 141: 727-31.
20. Whyte MP, Wenkert D, McAlister WH, Mughal Z, Freemont AJ, Whitehouse R, Baildam E, Mumm S., Chronic recurrent multifocal osteomyelitis mimicked in childhood hypophosphatasia. J Bone Miner Res. 2009; 24: 1493-1505.
21. Whyte MP., Atypical femoral fractures, bisphosphonates and adult hypophosphatasia. J Bone Miner Res. 2009; 24: 1132-4.
22. Steinbach HL, Noetzli M., Roentgen appearance of the skeleton in osteomalacia and rickets. Am J Roentgenol Radium Ther Nucl Med. 1964; 91: 955-72.
23. Dell R, Greene D, Ott S, Silverman S, Eisemon E, Funahashi T, Adams A., A retrospective analysis of all atypical femoral fractures seen in a large California HMO from the years 2007 to 2009. J Bone Miner Res. 2010; 25 (Suppl 1): S61. [Abstract 2012].
24. Otero JE, Gottesman GS, McAlister WH, et al. Severe skeletal toxicity from protracted etidronate therapy for generalized arterial calcification of infancy. (submitted for publication).
25. Vaisman DN, McCarthy AD, Cortizo AM., Bone-specific alkaline phosphatase activity is inhibited by bisphosphonates: role of divalent cations. Biol Trace Elem Res. 2005 May; 104 (2): 131-40.
26. Giusti A, Hamdy NA, Dekkers OM, Ramautar SR, Dijkstra S, Papapoulos SE., Atypical fractures and bisphosphonate therapy: a cohort study of patients with femoral fracture with radiographic adjudication of fracture site and features. Bone. 2011 May; 48 (5): 966-71.
27. Mornet E., The Tissue Nonspecific Alkaline Phosphatase Gene Mutation Database. [Internet]. Yvelines, France: SESEP Laboratory and the Human Molecular Genetics laboratory of the University of Versailles-Saint Quentin en Yvelines, France; [updated 2011 Dec 21; cited 2012 Feb 7]. Available from:.
28. Taillandier A, Lia-Baldini AS, Mouchard M, et al. Twelve novel mutations in the tissue-nonspecific alkaline phosphatase gene (ALPL) in patients with various forms of hypophosphatasia. Hum Mutat. 2001; 18: 83-4.
29. Whyte MP, Kurtzberg J, McAlister WH, et al. Marrow cell transplantation for infantile hypophosphatasia. J Bone Miner Res. 2003; 18: 624-36.
30. Henthorn PS, Raducha M, Fedde KN, Lafferty MA, Whyte MP., Different missense mutations at the tissue-nonspecific alkaline phosphatase gene locus in autosomal recessively inherited forms of mild and severe hypophosphatasia. Proc Natl Acad Sci U S A. 1992; 89: 9924-8.
31. Orimo H, Girschick HJ, Goseki-Sone M, Ito M, Oda K, Shimada T., Mutational analysis and functional correlation with phenotype in German patients with childhood-type hypophosphatasia. J Bone Miner Res. 2001; 16: 2313-9.
32. Fraser D., Hypophosphatasia. Am J Med. 1957; 22: 730-46.
33. Mornet E, Yvard A, Taillandier A, et al. A molecular-based estimation of the prevalence of hypophosphatasia in a European population. Ann Hum Genet. 2011; 75: 439-45.
34. Nielson CM, Zmuda JM, Carlos AS, et al. Rare coding variants in ALPL are associated with low serum alkaline phosphatase and low bone mineral density. J Bone Miner Res. 2012; 27: 93-103.
35. Reynolds RD, Lorenc RS, Wieczorek E, Pronicka E., Extremely low serum pyridoxal 5'-phosphate in children with familial hypophosphatemic rickets. Am J Clin Nutr. 1991; 53: 698-701.
36. Cheung CP, Suhadolnik RJ., Analysis of inorganic pyrophosphate at the picomole level. Anal Biochem. 1977; 83: 61-3.
37. Cheung A, Tile L, Austin N, et al. Use of teriparatide in patients with atypical femur fractures (abstract). J Bone Miner Res. 2011; 26: S225.
38. Whyte MP, Greenberg CR, Salman NJ, et al. Enzyme-replacement therapy in life-threatening hypophosphatasia. N Engl J Med. 2012; 366: 904-13.