8q23.3 and 11q23.1 as modifying loci influencing the risk for CRC in Lynch syndrome

European Journal of Human Genetics

Volumn 20, Issue 5, 2012, Pages 487-488

  Talseth Palmer, Bente A ^a,b   Scott, Rodney J ^a,b   Vasen, Hans F A ^c   Wijnen, Juul T ^d  

^a UNIVERSITY OF NEWCASTLE   (Australia)

^b JOHN HUNTER HOSPITAL   (Australia)

^c Foundation for the Detection of Hereditary Tumours   (Netherlands)

^d LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN MLH1; PROTEIN MSH2;

ALLELE; CANCER RISK; CHROMOSOME 11Q; CHROMOSOME 8Q; COLORECTAL CANCER; GENE LOCUS; GENOTYPE; HEREDITARY NONPOLYPOSIS COLORECTAL CANCER; HETEROZYGOSITY; HUMAN; LETTER; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

COLORECTAL NEOPLASMS; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; DNA MISMATCH REPAIR; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MUTATION;

EID: 84859904328     PISSN: 10184813     EISSN: 14765438     Source Type: Journal    
DOI: 10.1038/ejhg.2011.232     Document Type: Letter

References (3)

1. Houlle S, Charbonnier F, Houivet E et al: Evaluation of Lynch syndrome modifier genes in 748 MMR mutation carriers. Eur J Hum Genet 2011; 19: 887-892.
2. Wijnen JT, Brohet RM, van Eijk R et al: Chromosome 8q23.3 and 11q23.1 variants modify colorectal cancer risk in Lynch syndrome. Gastroenterology 2009; 136: 131-137.
3. Talseth-Palmer BA, Brenne IS, Ashton KA et al: Colorectal cancer susceptibility loci on chromosome 8q23.3 and 11q23.1 as modifiers for disease expression in lynch syndrome. J Med Genet 2011; 48: 279-284.