Natural killer cells: From basic research to treatments

Frontiers in Immunology

Volumn 2, Issue JUN, 2011, Pages

  Vivier, Eric ^a,b,c,d   Ugolini, Sophie ^a,b,c  

^a CENTRE D IMMUNOLOGIE DE MARSEILLE LUMINY   (France)

^b INSERM   (France)

^c CNRS   (France)

^d HÔPITAL DE LA CONCEPTION   (France)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84859899944     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2011.00018     Document Type: Article

References (56)

1. Anfossi, N., Andre, P., Guia, S., Falk, C. S., Roetynck, S., Stewart, C. A., Breso, V., Frassati, C, Reviron, D., Middleton, D., Romagne, F., Ugolini, S., and Vivier, E. (2006). Human NKcell education by inhibitory receptors for MHC class I. Immunity 2S, 331-342.
2. Bauer, S., Groh, V., Wu, J., Steinle, A., Phillips, J. H., Lanier, L.L., and Spies, T. (1999). Activation of NKcells andT cells by NKG2D, areceptor for stress-inducible MICA. Science 285, 727-729.
3. Bix, M., Liao, N.-S., Zijlstra, M., Loring, J., Jaenisch, R., and Raulet, D. (1991). Rejection of class I MHC-deficient haemopoietic cells by irradiated MHC-matched mice. Nature 349, 329-331.
4. Bottino, C, Moretta, L., and Moretta, A. (2006). NK cell activating receptors and tumor recognition in humans. Curr. Top. Microbiol Immunol 298, 175-182.
5. Brandt, C. S., Baratin, M., Yi, E. C, Kennedy, J., Gao, Z., Fox, B., Haldeman, B., Ostrander, C. D., Kaifu, T., Chabannon, C, Moretta, A., West, R., Xu, W., Vivier, E., and Levin, S. D. (2009). The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans. J. Exp. Med. 206, 1495-1503.
6. Brodin, P., Karre, K., and Hoglund, P. (2009). NK cell education: not an on-off switch but a tunable rheostat. Trends Immunol 30, 143-149.
7. Burshtyn, D. N., Scharenberg, A. M., Wagtmann, N., Rajagopalan, S., Berrada, K., Yi, T., Kinet, J.-P., and Long, E. O. (1996). Recruitment of tyrosine phos-phatase HCP by the killer cell inhibitory receptor. Immunity 4, 77-85.
8. Cooley, S., June, C. H., Schoenberger, S. P., and Miller, J. S. (2007). Adoptive therapy with T cells/NK cells. Biol Blood Marrow Transplant. 13(Suppl.) 1, 33-42.
9. Cooper, M. A., Elliott, J. M., Keyel, P. A., Yang, L., Carrero, J.A., andYokoyama, W.M. (2009).Cytokine-induced memory-like natural killer cells. Proc. Nail. Acad. Sci. U.S.A. 106, 1915-1919.
10. Degli-Esposti, M. A., and Smyth, M. J. (2005). Close encounters of different kinds: dendritic cells and NK cells take centre stage. Nat. Rev. Immunol. 5, 112-124.
11. Elliott, J. M., Wahle, J. A., andYokoyama, W. M. (2010). MHC class I-deflcient natural killer cells acquire a licensed phenotype after transfer into an MHC class I-sufficient environment. J. Exp. Med. 207, 2073-2079.
12. Fernandez, N. C, Treiner, E., Vance, R. E., Jamieson, A. M., Lemieux, S., and Raulet, D. H. (2005). A subset of natural killer cells achieves self-tolerance without expressing inhibitory receptors specific for self-MHC molecules. Blood 105, 4416-4423.
13. Gasser, S., Orsulic, S., Brown, E. J., and Raulet, D. H. (2005). The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor. Nature 436, 1186-1190.
14. Gasser, S., and Raulet, D. H. (2006). Activation and self-tolerance of natural killer cells. Immunol. Rev. 214, 130-142.
15. Guerra, N., Tan, Y. X., Joncker, N. T., Choy, A., Gallardo, R, Xiong, N., Knoblaugh, S., Cado, D., Greenberg, N. M., and Raulet, D. H. (2008). NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy. Immunity 28, 571-580.
16. Guia, S., Jaeger, B. N., Piatek, S., Mailfert, S., Trombik, T., Fenis, A., Chevrier, N., Walzer, T., Kerdiles, Y. M., Marguet, D., Vivier, E., and Ugolini, S. (2011). Confinement of activating receptors at the plasma membrane controls natural killer cell tolerance. Sci. Signal. 4, ra21.
17. Herberman, R. B., Nunn, M. E., and Lavrin, D. H. (1975). Natural cytotoxic reactivity of mouse lym-phoid cells against syngeneic acid allogeneic tumors. I. Distribution of reactivity and specificity. Int. J. Cancer 16, 216-229.
18. Hoglund, R, and Brodin, P. (2010). Current perspectives of natural killer cell education by MHC class I molecules. Nat. Rev. Immunol. 10, 724-734.
19. Joncker, N. T., Fernandez, N. C, Treiner, E., Vivier, E., and Raulet, D. H. (2009). NK cell responsiveness is tuned commensurate with the number of inhibitory receptors for self-MHC class I: the rheostat model. J. Immunol. 182, 4572-4580.
20. Joncker, N. T., Shifrin, N., Delebecque, E, and Raulet, D. H. (2010). Mature natural killer cells reset their responsiveness when exposed to an altered MHC environment. J. Exp. Med. 207, 2065-2072.
21. Karre, K., Ljunggren, H. G., Piontek, G., and Kiessling, R. (1986). Selective rejection of H-2-deficientlymphoma variants suggests alternative immune defense strategy. Nature 319, 675-678.
22. Kiessling, R., Klein, E., and Wigzell, H. (1975).Natural killer cells in the mouse. I. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Specificity and distribution according to genotype. Eur. J. Immunol. 5, 112-117.
23. Kim, S., Poursine-Laurent, J., Truscott, S. M., Lybarger, L., Song, Y. J., Yang, L, French, A. R., Sunwoo, J. B., Lemieux, S., Hansen, T. H., and Yokoyama, W. M. (2005). Licensing of natural killer cells by host major histocompatibility complex class I molecules. Nature 436, 709-713.
24. Krebs, P., Barnes, M. J., Lampe, K., Whitley, K., Bahjat, K. S., Beutler, B., Janssen, E., and Hoebe, K. (2009). NK cell-mediated killing of target cells triggers robust antigen-specific T cell-mediated and humoral responses. Blood 113, 6593-6602.
25. Kumar, V, and McNerney, M. E. (2005). A new self: MHC-class-I-independent natural-killer-cell self-tolerance. Nat. Rev. Immunol. 5, 363-374.
26. Lanier, L. L. (2005). NK cell recognition. Annu. Rev. Immunol. 23, 225-274.
27. Ljunggren, H. G., and Malmberg, K. J. (2007). Prospects for the use of NK cells in immunotherapy of human cancer. Nat. Rev. Immunol. 7, 329-339.
28. Lu, L., Ikizawa, K., Hu, D., Werneck, M.B., Wucherpfennig, K. W., and Cantor, H. (2007). Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2 A inhibitory pathway. Immunity 26, 593-604.
29. Moretta, A. (2002). Natural killer cells and dendritic cells: rendezvous in abused tissues. Nat. Rev. Immunol. 2, 957-964.
30. Moretta, A., Bottino, C, Vitale, M., Pende, D., Cantoni, C, Mingari, M. C, Biassoni, R., and Moretta, L. (2001). Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis. Annu. Rev. Immunol. 19, 197-223.
31. Moretta, L., and Moretta, A. (2004). Unravelling natural killer cell function: triggering and inhibitory human NK receptors. EMBOJ. 23, 255-259.
32. Olcese, L., Lang, P., Vely, E, Cambiaggi, A., Marguet, D., Blery, M., Hippen, K. L., Biassoni, R., Moretta, A., Moretta, L, Cambier, J. C, and Vivier, E. (1996). Human and mouse killer-cell inhibitory receptors recruit PTP1C and PTP1D protein tyrosine phos-phatases. J. Immunol. 156, 4531-4534.
33. Oldham, R. K., and Herberman, R. B. (1973). Evaluation of cell-mediated cytotoxic reactivity against tumor associated antigens with 1251-iododeoxyuridine labeled target cells. J. Immunol. Ill, 862-871.
34. O'Leary J, G., Goodarzi, M., Drayton, D. L., and von Andrian, U. H. (2006). T cell- and B cell-independent adaptive immunity mediated by natural killer cells. Nat. Immunol. 7, 507-516.
35. Orr, M. T., Murphy, W. J., and Lanier, L. L. (2010). 'Unlicensed' natural killer cells dominate the response to cytomegalovirus infection. Nat. Immunol. 11, 321-327.
36. Parham, P. (2005). MHC class I molecules and KIRs in human history, health and survival. Nat. Rev. Immunol. 5, 201-214.
37. Paust, S., Gill, H. S., Wang, B. Z., Flynn, M. P., Moseman, E. A., Senman, B., Szczepanik, M., Telenti, A., Askenase, P. W., Compans, R.W., and von Andrian, U.H. (2010). Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses. Nat. Immunol. 11, 1127-1135.
38. Raulet, D. H. (2004). Interplay of natural killer cells and their receptors with the adaptive immune response. Nat. Immunol. 5, 996-1002.
39. Raulet, D. H., and Guerra, N. (2009). Oncogenic stress sensed by the immune system: role of natural killer cell receptors. Nat. Rev. Immunol. 9, 568-580.
40. Raulet, D. H., and Vance, R. E. (2006). Self-tolerance of natural killer cells. Nat. Rev. Immunol. 6, 520-531.
41. Romagne, E, Andre, P., Spee, P., Zahn, S., Anfossi, N., Gauthier, L., Capanni, M., Ruggeri, L., Benson, D. M. Jr., Blaser, B. W., Delia Chiesa, M., Moretta, A., Vivier, E., Caligiuri, M. A., Velardi, A., and Wagtmann, N. (2009). Preclinical characterization of 1-7F9, a novel human an ti-KIR therapeutic antibody that augments natural killer-mediated killing of tumor cells. Blood 114, 2667-2677.
42. Ruggeri, L., Capanni, M., Urbani, E., Perruccio, K., Shlomchik, W. D., Tosti, A., Posati, S., Rogaia, D., Frassoni, E, Aversa, E, Martelli, M. F., and Velardi, A. (2002). Effectiveness of donor natural killer cell allo-reactivity in mismatched hematopoietic transplants. Science 295, 2097-2100.
43. Soderquest, K., Walzer, T., Zafirova, B., Klavinskis, L. S., Polic, B., Vivier, E., Lord, G. M., and Martin-Fontecha, A. (2011). Cutting edge: CD8+ T cell priming in the absence of NK cells leads to enhanced memory responses. J. Immunol. 186, 3304-3308.
44. Sola, C, Andre, P., Lemmers, C, Fuseri, N., Bonnafous, C, Blery, M., Wagtmann, N. R., Romagne, F., Vivier, E., and Ugolini, S. (2009). Genetic and antibody-mediated reprogramming of natural killer cell missing-self recognition in vivo. Proc. Nail. Acad. Sci. U.S.A. 106, 12879-12884.
45. Sun, J. C, Beilke, J. N., and Lanier, L. L. (2009). Adaptive immune features of natural killer cells. Nature 457, 557-561.
46. Tay, C. H., Welsh, R. M., and Brutkiewicz, R. R. (1995). NK cell response to viral infections in beta 2-microglobulin-deficient mice. J. Immunol. 154, 780-789.
47. Terme, M., Ullrich, E., Delahaye, N. E, Chaput, N., and Zitvogel, L. (2008). Natural killer cell-directed therapies: moving from unexpected results to successful strategies. Nat. Immunol. 9, 486-494.
48. Ugolini, S., and Vivier, E. (2009). Immunology: natural killer cells remember. Nature 457, 544-545.
49. Unni, A. M., Bondar, T., and Medzhitov, R. (2008). Intrinsic sensor of oncogenic transformation induces a signal for innate immunosurveillance. Proc. Nail. Acad. Sci. U.S.A. 105, 1686-1691.
50. Vivier, E., Nunes, J. A., and Vely, F. (2004). Natural killer cell signaling pathways. Science 306, 1517-1519.
51. Vivier, E., Raulet, D. H., Moretta, A., Caligiuri, M. A., Zitvogel, L., Lanier, L. L., Yokoyama, W. M., and Ugolini, S. (2011). Innate or adaptive immunity? The example of natural killer cells. Science 331, 44-49.
52. Vivier, E., Tomasello, E., Baratin, M., Walzer, T., and Ugolini, S. (2008). Functions of natural killer cells. Nat. Immunol. 9, 503-510.
53. Walzer, T., Dalod, M., Robbins, S. H., Zitvogel, L., and Vivier, E. (2005). Natural-killer cells and dendritic cells: "l'union fait la force". Blood 106, 2252-2258.
54. Yokoyama, W M., and Kim, S. (2006). How do natural killer cells find self to achieve tolerance? Immunity 24, 249-257.
55. Yokoyama, W M., and Plougastel, B. F. (2003). Immune functions encoded by the natural killer gene complex. Nat. Rev. Immunol. 3, 304-316.
56. Zitvogel, L., Apetoh, L., Ghiringhelli, E, and Kroemer, G. (2008). Immunological aspects of cancer chemotherapy. Nat. Rev. Immunol. 8, 59-73.