Protective effect of morin on lipid peroxidation and lipid profile in ammonium chloride-induced hyperammonemic rats

Asian Pacific Journal of Tropical Disease

Volumn 2, Issue 2, 2012, Pages 103-106

  Subash, S ^a   Subramanian, P ^a  

^a ANNAMALAI UNIVERSITY   (India)

Author keywords

Ammonia; Ammonium chloride; Lipid peroxidation; Lipids; Morin

Indexed keywords

3,5,7,2',4' PENTAHYDROXYFLAVONE; AMMONIA; AMMONIUM CHLORIDE; CHOLESTEROL; FATTY ACID; MORIN; PHOSPHOLIPID; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; UREA;

AMMONIA BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CHEMICAL STRUCTURE; CHOLESTEROL BLOOD LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; FATTY ACID BLOOD LEVEL; HYPERAMMONEMIA; LIPID PEROXIDATION; MALE; NONHUMAN; PHOSPHOLIPID BLOOD LEVEL; PRIORITY JOURNAL; RAT; TREATMENT RESPONSE; TRIACYLGLYCEROL BLOOD LEVEL; UREA BLOOD LEVEL;

EID: 84859893746     PISSN: 22221808     EISSN: None     Source Type: Journal    
DOI: 10.1016/S2222-1808(12)60025-5     Document Type: Article

References (22)

1. Justin Thenmozhi A, Subramanian P Hepatoprotective effect of Momordica charantia in ammonium chloride induced hyperammonemic rats. J Pharm Res 2011, 4:700-702.
2. Vijayakumar N, Subramanian P Neuroprotective effect of Semecarpus anacardium against hyperammonemia in rats. J Pharm Res 2010, 3:1564-1568.
3. Harikrishnan B, Subramanian P, Subash S Effect of Withania somnifera root powder on the levels of circulatory lipid peroxidation and liver marker enzymes in chronic hyperammonemia. E-J Chem 2008, 5:872-877.
4. Harikrishnan B, Subramanian P, Subash S Antihyperammonemic effect of Withania somnifera on ammonium chloride induced wistar rats. J Cell Tissue Res 2008, 8:1417-1420.
5. Subash S, Subramanian P Impact of morin (a bioflavonoid) on ammonium chloride-mediated oxidative damage in rat kidney. Int J Nutr Pharmacol Neurol Dis 2011, 1:174-178.
6. Sivaramakrishnan V, Moorthy Shilpa PN, Praveen Kumar VR, Niranjali Devaraj S Attenuation of N-nitrosodiethylamine-induced hepatocellular carcinogenesis by a novel flavonol-Morin. Chem Bio Interact 2008, 171:79-88.
7. Rui Zhang R, Kang AK, Jing Piao M, Maeng YH, Lee KH, Chang WY, et al. Cellular protection of morin against the oxidative stress induced by hydrogen peroxide. Chem Biol Interact 2009, 177:21-27.
8. Sivaramakrishnan V, Niranjali Devaraj S Morin fosters apoptosis in experimental hepatocellular carcinogenesis model. Chem Biol Interact 2010, 183:284-292.
9. Subash S, Subramanian P Morin improves the expression of urea cycle enzymes in hyperammonemic rats. J Pharm Res 2010, 3:2557-2560.
10. Subash S, Subramanian P, Sivaperumal R Antihyperammonemic effect of morin: a dose dependent study. J Cell Tissue Res 2007, 7:1043-1046.
11. Wolheim DF Preanalytical increase of ammonia in blood specimens from healthy subjects. Clin Chem 1984, 30:906-908.
12. Varley H, Gowenlock AH, Bell M Practical clinical biochemistry 1998, CBS Publishers, Delhi. 4th ed.
13. Nichans WG, Samuelson B Formation of MDA from phospholipids arachidonate during microsomal lipid peroxidation. Eur J Biochem 1968, 6:126-130.
14. Jiang ZY, Hunt JV, Wolff SP Ferrous ion oxidation in the presence of xylenol orange for detection of lipid hydroperoxide in low density lipoprotein. Anal Biochem 1992, 202:384-387.
15. Zlatki A, Zak B, Boyle AJ A new method for the direct determination of serum cholesterol. J Lab Clin Med 1953, 45:486.
16. Foster LB, Dunn RT Stable reagents for determination of serum triglycerides by a colorimetric Hantzsch condensation method. Clin Chem 1973, 19:338-340.
17. Falholt K, Falholt W, Lund B An easy colorimetric method for routine determination of free fatty acids in plasma. Clin Chim Acta 1973, 46:105-111.
18. Zilversmit DB, Davis A Micro determination of plasma phospholipids by trichloroacetic acid precipitation. J Lab Clin Med 1950, 35:155-160.
19. Subash S, Subramanian P Effect of morin on the levels of circulatory liver markers and redox status in experimental chronic hyperammonaemic rats. Singapore Med J 2008, 49:650-655.
20. Subash S, Subramanian P Morin a flavonoid exerts antioxidant potential in chronic hyperammonemic rats: a biochemical and histopathological study. Mol Cell Biochem 2009, 327:153-161.
21. Campos-Esparza MR, Sanchez-Gomez MV, Matute C Molecular mechanisms of neuroprotection by two natural antioxidant polyphenols. Cell Calcium 2009, 45:358-368.
22. Essa MM, Ali AA, Waly MI, Guillemin GJ, Subramanian P Effect of leaves on serum lipids in ammonium chloride induced experimental hyperammonemic rats. Int J Biol Med Res 2010, 3:71-73.