The effect of deletion of the edema factor on Bacillus anthracis pathogenicity in guinea pigs and rabbits

Microbial Pathogenesis

Volumn 52, Issue 1, 2012, Pages 55-60

  Levy, Haim ^a   Weiss, Shay ^a   Altboum, Zeev ^a   Schlomovitz, Josef ^a   Rothschild, Nili ^a   Glinert, Itai ^a   Sittner, Assa ^a   Kobiler, David ^a  

^a ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH   (Israel)

Author keywords

Bacillus anthracis; Edema factor; Intranasal instillation; Lethal factor; Mutagenesis; Pathogenicity

Indexed keywords

ADENYLATE CYCLASE; ANTHRAX TOXIN; BACTERIAL PROTEIN; EDEMA FACTOR PROTEIN; EDEMA TOXIN; LETHAL TOXIN; UNCLASSIFIED DRUG; BACTERIAL ANTIGEN; BACTERIAL TOXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACILLUS ANTHRACIS; BACTERIAL COLONIZATION; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERIUM MUTANT; CONTROLLED STUDY; DEATH; FEMALE; GENE DELETION; GUINEA PIG; MORTALITY; NONHUMAN; PRIORITY JOURNAL; RABBIT; RESPIRATORY TRACT INFECTION; ANIMAL; ANTHRAX; COMPARATIVE STUDY; DISEASE MODEL; GENETICS; HUMAN; METABOLISM; MICROBIOLOGY; PATHOGENICITY; VIRULENCE;

BACILLUS ANTHRACIS; CAVIA; ORYCTOLAGUS CUNICULUS;

ADENYLATE CYCLASE; ANIMALS; ANTHRAX; ANTIGENS, BACTERIAL; BACILLUS ANTHRACIS; BACTERIAL TOXINS; DISEASE MODELS, ANIMAL; FEMALE; GENE DELETION; GUINEA PIGS; HUMANS; RABBITS; VIRULENCE;

EID: 84859891012     PISSN: 08824010     EISSN: 10961208     Source Type: Journal    
DOI: 10.1016/j.micpath.2011.10.002     Document Type: Article

References (21)

1. Ivins B.E., Ezzell J.W., Jemski J., Hedlund K.W., Ristroph J.D., Leppla S.H. Immunization studies with attenuated strains of Bacillus anthracis. Infection and Immunity 1986, 52:454-458.
2. Van der Goot G., Yang J.A.T. Receptors of anthrax toxin and cell entry. Molecular Aspects of Medicine 2009, 30:406-412.
3. Moayeri M., Leppla S.H. Cellular and systemic effects of anthrax lethal toxin and edema toxin. Molecular Aspects of Medicine 2009, 30:439-455.
4. Fiorella Tonello C.M. The anthrax lethal factor and its MAPK kinase-specific metalloprotease activity. Molecular Aspects of Medicine 2009, 30:431-438.
5. Pezard C., Berche P., Mock M. Contribution of individual toxin components to virulence of Bacillus anthracis. Infection and Immunity 1991, 59:3472-3477.
6. Levy H., Weiss S., Altboum Z., Rothchld N., Blachinsky E., Kobiler D. Lethal factor is not requierd for Bacillus anthracis virulence in guinea pigs and rabbits. Microbial Pathogenesis 2011, 51:7.
7. Firoved A.M., Miller G.F., Moayeri M., Kakkar R., Shen Y., Wiggins J.F., et al. Bacillus anthracis edema toxin causes Extensive tissue lesions and Rapid Lethality in mice. American Journal of Pathology 2005, 167:1309-1320.
8. Dumetz F., Jouvion G., Khun H., Glomski I.J., Corre J.-P., Rougeaux C., et al. Noninvasive imaging Technologies Reveal edema toxin as Key virulence factor in anthrax. Biophysical Imaging and Computational Biology 2011, 178:13.
9. Ebrahimi C.M., Sheen T.R., Renken C.W., Gottlieb R.A., Doran K. Contribution of lethal toxin and edema toxin to the Pathogenesis fo anthrax Meningitis. Infection and Immunity 2011, 79:9.
10. Guichard A., McGillivivray S.M., Cruz-Moreno B., van Sorge N.M., Bier E. Anthrax toxins cooperatively inhibit enocytic recycling by the Rab11/Sec15 exocyst. Nature 2010, 467:6.
11. Sambrook J., Fritsch E.F., Maniatis T. Molecular cloining a laboratory manual 1989, Cold Spring Harbor Laboratory Press.
12. Welkos S.L., Marrero R. Pathogenesis and host resistance to infection: amodel system and analysis of capsule synthesis and regulation by Bacillus anthracis 1996, CRC Press, Boca Raton.
13. Kobiler D., Gozes Y., Rosenberg H., Marcus D., Reuveny S., Altboum Z. Efficiency of protection of guinea pigs against infection with Bacillus anthracis spores by passive immunization. Infection and Immunity 2002, 70:544-560.
14. Levy H., Fisher M., Ariel N., Altboum Z., Kobiler D. Identification of strain specific markers in Bacillus anthracis by random amplification of polymorphic DNA. FEMS Microbiology Letters 2005, 244:199-205.
15. Posfai G., Kolisnychenko V., Bereczki Z., Blattner F. Markerkess gene replacement in Escherichia coli stimulated by a double-strand break in the chromosome. Nucleic Acids Research 1999, 27:7.
16. Gat O., Inbar I., Aloni-Grinstein R., Zahavy E., Kronman C., Mendelson I., et al. Use of a promoter trap system in Bacillus anthracis and Bacillus subtilis for the development of recombinant protective antigen-based vaccines. Infection and Immunity 2003, 71:801-813.
17. Cohen S., Mendelson I., Altboum Z., Kobiler D., Elhanany E., Bino T., et al. Attenuated nontoxinogenic and nonencapsulated recombinant Bacillus anthracis spore vaccines protect against anthrax. Infection and Immunity 2000, 68:4549-4558.
18. Janes B.K., Stibitz S. Routine Markerless gene replacement in Bacillus anthracis. Infection and Immunity 2006, 74:5.
19. Reed L.J., Muench H. A simple method of estimating fifty per cent endpoints. Americam Journal of Hygiene 1938, 27:493-497.
20. Gat O., Mendelson I., Chitlaru T., Ariel N., Altboum Z., Levy H., et al. The solute-binding component of a putative Mn(II) ABC transporter (MntA) is a novel Bacillus anthracis virulence determinant. Molecular Microbiology 2005, 58:533-551.
21. Weiss S., Kobiler D., Levy H., Marcus H., Pass A., Rothschild N., et al. Immunological correlates for protection against intranasal challenge of Bacillus anthracis spores conferred by a protective antigen-based vaccine in rabbits. Infection and Immunity 2006, 74:394-398.