Immunomodulatory therapy in recurrent acute necrotizing encephalopathy ANE1: Is it useful?

Brain and Development

Volumn 34, Issue 5, 2012, Pages 384-391

  Bergamino, Laura ^a   Capra, Valeria ^b   Biancheri, Roberta ^b   Rossi, Andrea ^b   Tacchella, Angela ^b   Ambrosini, Linda ^b   Mizuguchi, Masashi ^c   Saitoh, Makiko ^c   Marazzi, Maria Grazia ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b G GASLINI INSTITUTE   (Italy)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

Acute; Encephalopathy; Necrotizing; RANBP2; Recurrent; Steroid

Indexed keywords

ACICLOVIR; ANTIBIOTIC AGENT; CYSTEINE; DEXAMETHASONE; IMMUNOGLOBULIN; IMMUNOMODULATING AGENT; MANNITOL; MEMBRANE PROTEIN; METHYLPREDNISOLONE; PHENOBARBITAL; PROTEIN RANBP2; THREONINE; UNCLASSIFIED DRUG;

ANTIBIOTIC THERAPY; ARTICLE; ARTIFICIAL VENTILATION; CASE REPORT; CHILD; CORTICOSTEROID THERAPY; DISEASE SEVERITY; DYSPHAGIA; FEVER; GASTROENTERITIS; GENE MUTATION; GLASGOW COMA SCALE; HUMAN; HYPOTHESIS; IMMUNOMODULATION; INTUBATION; ITALY; LEIGH DISEASE; MALE; MUSCLE HYPOTONIA; NEUROIMAGING; PHARYNGITIS; PRESCHOOL CHILD; RECURRENT DISEASE; SEIZURE; VIRUS INFECTION;

BRAIN; CHILD, PRESCHOOL; DEXAMETHASONE; GLUCOCORTICOIDS; HUMANS; IMMUNOGLOBULINS, INTRAVENOUS; IMMUNOMODULATION; LEUKOENCEPHALITIS, ACUTE HEMORRHAGIC; MAGNETIC RESONANCE SPECTROSCOPY; MALE; RECURRENCE; TREATMENT OUTCOME;

EID: 84859888890     PISSN: 03877604     EISSN: 18727131     Source Type: Journal    
DOI: 10.1016/j.braindev.2011.08.001     Document Type: Article

References (15)

1. Mizuguchi M., Abe J., Mikkaichi K., Noma S., Yoshida K., Yamanaka T., et al. Acute necrotising encephalopathy of childhood: a new syndrome presenting with multifocal, symmetric brain lesions. J Neurol Neurosurg Psychiatry 1995, 58:555-561.
2. Mizuguchi M. Acute necrotizing encephalopathy of childhood: a novel form of acute encephalopathy prevalent in Japan and Taiwan. Brain Dev 1997, 19:81-92.
3. Mizuguchi M., Yamanouchi H., Ichiyama T., Shiomi M. Acute encephalopathy associated with influenza and other viral infections. Acta Neurol Scand 2007, 115:45-56.
4. Mastroyanni S.D., Gionnis D., Voudris K., Skardoutsou A., Mizuguchi M. Acute necrotizing encephalopathy of childhood in non-Asian patients: report of three cases and literature review. J Child Neurol 2006, 21:872-879.
5. Neilson D.E., Eiben R.M., Waniewski S., Hoppel C.L., Varnes M.E., Bangert B.A., et al. Autosomal dominant acute necrotizing encephalopathy. Neurology 2003, 61:226-230.
6. Neilson D.E., Feiler H.S., Wilhelmsen K.C., Lynn A., Eiben R.M., Kerr D.S., et al. Autosomal dominant acute necrotizing encephalopathy maps to 2q12.1-2q13. Ann Neurol 2004, 55:291-294.
7. Neilson D.E., Adams M.D., Orr C.M., Schelling D.K., Elben R.M., Kerr D.S., et al. Infection-triggered familial or recurrent cases of acute necrotizing encephalopathy caused by mutations in a component of the nuclear pore, RANBP2. Am J Hum Genet 2009, 84:44-51.
8. Neilson D.E. The interplay of infection and genetics in acute necrotizing encephalopathy. Curr Opin Pediatr 2010, 22:751-757.
9. López-Laso E., Mateos-González M.E., Pérez-Navero J.L., Camino-León R., Briones P., Neilson D.E. Infection-triggered familial or recurrent acute necrotizing encephalopathy. An Pediatr (Barc) 2009, 71:235-239.
10. Marco E.J., Anderson J.E., Neilson D.E., Strober J.B. Acute necrotizing encephalopathy in 3 brothers. Pediatrics 2010, 125:e693-e698.
11. Manara R., Franzoi M., Cogo P., Battistella P.A. Acute necrotizing encephalopathy: combined therapy and favorable outcome in a new case. Childs Nerv Syst 2006, 22:1231-1236.
12. Okumura A., Mizuguchi M., Kidokoro H., Tanaka M., Abe S., Hosoya M., et al. Outcome of acute necrotizing encephalopathy in relation to treatment with corticosteroids and gammaglobulin. Brain Dev 2009, 31(3):221-227.
13. Loh N.R., Appleton D.B. Untreated recurrent acute necrotising encephalopathy associated with RANBP2 mutation, and normal outcome in a Caucasian boy. Eur J Pediatr 2010, 169:1299-1302.
14. Gika A.D., Rich P., Gupta S., Neilson D.E., Clarke A. Recurrent acute necrotizing encephalopathy following influenza A in a genetically predisposed family. Dev Med Child Neurol 2010, 52:99-102.
15. Gilson C., McFarland R., Forsyth R. Autosomal dominant acute necrotising encephalopathy: a case report with possible disease-expression modification by coincidental homocysteinuria. Eur J Paediatr Neurol 2011, 15:174-176.