Progressive Primary Sclerosing Cholangitis Requiring Liver Transplantation Is Associated With Reduced Need for Colectomy in Patients With Ulcerative Colitis

Clinical Gastroenterology and Hepatology

Volumn 10, Issue 5, 2012, Pages 540-546

  Navaneethan, Udayakumar ^a   Venkatesh, Preethi G K ^a   Mukewar, Saurabh ^a   Lashner, Bret A ^a   Remzi, Feza H ^a   McCullough, Arthur J ^a   Kiran, Ravi P ^a   Shen, Bo ^a   Fung, John J ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Inflammatory Bowel Disease; Liver Disease; Prognostic; Risk Factors

Indexed keywords

AZATHIOPRINE; MERCAPTOPURINE; URSODEOXYCHOLIC ACID;

ADULT; ARTICLE; BILE DUCT CARCINOMA; CANCER RISK; CLINICAL FEATURE; COLON CARCINOMA; COLON RESECTION; COLON TUMOR; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE COURSE; FEMALE; HUMAN; LIVER GRAFT REJECTION; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; PRIMARY SCLEROSING CHOLANGITIS; TREATMENT OUTCOME; ULCERATIVE COLITIS;

ADULT; AGED; CHOLANGITIS, SCLEROSING; COHORT STUDIES; COLECTOMY; COLITIS, ULCERATIVE; FEMALE; HUMANS; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; TREATMENT OUTCOME;

EID: 84859852635     PISSN: 15423565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cgh.2012.01.006     Document Type: Article

References (20)

1. Navaneethan U., Shen B. Hepatopancreatobiliary manifestations and complications associated with inflammatory bowel disease. Inflamm Bowel Dis 2010, 16:1598-1619.
2. Olsson R., Danielsson A., Järnerot G., et al. Prevalence of primary sclerosing cholangitis in patients with ulcerative colitis. Gastroenterology 1991, 100:1319-1323.
3. Broomé U., Bergquist A. Primary sclerosing cholangitis, inflammatory bowel disease, and colon cancer. Semin Liver Dis 2006, 26:31-40.
4. Loftus E.V., Sandborn W.J., Lindor K.D., et al. Interactions between chronic liver disease and inflammatory bowel disease. Inflamm Bowel Dis 1997, 3:288-302.
5. Faubion W.A., Loftus E.V., Sandborn W.J., et al. Pediatric "PSC-IBD": a descriptive report of associated inflammatory bowel disease among pediatric patients with PSC. J Pediatr Gastroenterol Nutr 2001, 33:296-300.
6. Loftus E.V., Harewood G.C., Loftus C.G., et al. PSC-IBD: a unique form of inflammatory bowel disease associated with primary sclerosing cholangitis. Gut 2005, 54:91-96.
7. Heuschen U., Hinz U., Allemeyer E., et al. Backwash ileitis is strongly associated with colorectal carcinoma in ulcerative colitis. Gastroenterology 2001, 120:841-847.
8. Joo M., Abreu-e-Lima P., Farraye F., et al. Pathologic features of ulcerative colitis in patients with primary sclerosing cholangitis: a case-control study. Am J Surg Pathol 2009, 33:854-862.
9. Penna C., Dozois R., Tremaine W., et al. Pouchitis after ileal pouch anal anastomosis for ulcerative colitis occurs with increased frequency in patients with associated primary sclerosing cholangitis. Gut 1996, 38:234-239.
10. Shen B., Bennett A.E., Navaneethan U., et al. Primary sclerosing cholangitis is associated with endoscopic and histologic inflammation of the distal afferent limb in patients with ileal pouch-anal anastomosis. Inflamm Bowel Dis 2011, 17:1890-1900.
11. Marelli L., Xirouchakis E., Kalambokis G., et al. Does the severity of primary sclerosing cholangitis influence the clinical course of associated ulcerative colitis?. Gut 2011, 60:1224-1228.
12. Fausa O., Schrumpf E., Elgjo K. Relationship of inflammatory bowel disease and primary sclerosing cholangitis. Semin Liver Dis 1991, 11:31-39.
13. Rutter M., Saunders B., Wilkinson K., et al. Severity of inflammation is a risk factor for colorectal neoplasia in ulcerative colitis. Gastroenterology 2004, 126:451-459.
14. Kim W.R., Poterucha J.J., Wiesner R.H., et al. The relative role of the Child-Pugh classification and the Mayo natural history model in the assessment of survival in patients with primary sclerosing cholangitis. Hepatology 1999, 29:1643-1648.
15. Lundqvist K., Broomé U. Differences in colonic disease activity in patients with ulcerative colitis with and without primary sclerosing cholangitis: a case control study. Dis Colon Rectum 1997, 40:451-456.
16. Broomé U., Löfberg R., Lundqvist K., et al. Subclinical time span of inflammatory bowel disease in patients with primary sclerosing cholangitis. Dis Colon Rectum 1995, 38:1301-1305.
17. Berenyi M.R., Straus B., Cruz D. In vitro and in vivo studies of cellular immunity in alcoholic cirrhosis. Am J Dig Dis 1974, 19:199-205.
18. Aoki C.A., Bowlus C.L., Gershwin M.E. The immunobiology of primary sclerosing cholangitis. Autoimmun Rev 2005, 4:137-143.
19. Tung B.Y., Emond M.J., Haggitt R.C., et al. Ursodiol use is associated with lower prevalence of colonic neoplasia in patients with ulcerative colitis and primary sclerosing cholangitis. Ann Intern Med 2001, 134:89-95.
20. Pardi D.S., Loftus E.V., Kremers W.K., et al. Ursodeoxycholic acid as a chemopreventative agent in patients with ulcerative colitis and primary sclerosing cholangitis. Gastroenterology 2003, 124:889-893.