A randomized double-blind placebo-controlled pilot study to assess the efficacy of a 24-week topical treatment by latanoprost 0.1% on hair growth and pigmentation in healthy volunteers with androgenetic alopecia

Journal of the American Academy of Dermatology

Volumn 66, Issue 5, 2012, Pages 794-800

  Blume Peytavi, Ulrike ^a   Lönnfors, Sanna ^a   Hillmann, Kathrin ^a   Garcia Bartels, Natalie ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

androgenetic alopecia; hair density; hair growth; hair pigmentation; latanoprost; scalp pigmentation

Indexed keywords

LATANOPROST; PLACEBO; PROSTAGLANDIN;

ADULT; ARTICLE; BURN; CLINICAL ARTICLE; CLINICAL EVALUATION; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; ERYTHEMA; FOLLICULITIS; HAIR ANALYSIS; HAIR GROWTH; HUMAN; MALE; MALE TYPE ALOPECIA; PIGMENTATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCALP; TREATMENT DURATION; TREATMENT RESPONSE;

ADMINISTRATION, TOPICAL; ADULT; ALOPECIA; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; FOLLOW-UP STUDIES; HAIR; HUMANS; MALE; PIGMENTATION; PILOT PROJECTS; PROSTAGLANDINS F, SYNTHETIC; SEVERITY OF ILLNESS INDEX; TIME FACTORS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84859849330     PISSN: 01909622     EISSN: 10976787     Source Type: Journal    
DOI: 10.1016/j.jaad.2011.05.026     Document Type: Article

References (26)

1. Alm A, Grierson I, Shields MB. Side effects associated with prostaglandin analog therapy. Surv Ophthalmol 2008;53:S93-S195.
2. Costagliola C, Del Prete A, Verolino M, Antinozzi P, Fusco R, Parmeggiani F, et al. Effect of 0.005% latanoprost once daily on intraocular pressure in glaucomatous patients not adequately controlled by beta-blockers twice daily: a 3-year follow-up. Graefes Arch Clin Exp Ophthalmol 2002;240:379-86. (Pubitemid 36075612)
3. Chiba T, Kashiwagi K, Ishijima K, Furuichi M, Kogure S, Abe K, et al. A prospective study of iridial pigmentation and eyelash changes due to ophthalmic treatment with latanoprost. Jpn J Ophthalmol 2004;48:141-7. (Pubitemid 38453787)
4. Chou S-Y, Chou C-K, Kuang T-M, Hsu W-M. Incidence and severity of iris pigmentation on latanoprost-treated glaucoma eyes. Eye 2005;19:784-7. (Pubitemid 41030577)
5. Herndon LW, Williams RD, Wand M, Asrani S. Increased periocular pigmentation with ocular hypotensive lipid use in African Americans. Am J Ophthalmol 2003;135:713-5. (Pubitemid 36457983)
6. Kook MS, Lee K. Increased eyelid pigmentation associated with use of latanoprost. Am J Ophthalmol 2000;129:804-6. (Pubitemid 30604165)
7. Chien KH, Lu DW, Chen JT. Extensive facial skin pigmentation after latanoprost treatment. Cutan Ocul Toxicol 2009;28:185-7.
8. Demitsu T, Manabe M, Harima N, Sugiyama T, Yoneda T, Yamada N. Hypertrichosis induced by latanoprost. J Am Acad Dermatol 2001;44:721-3.
9. Johnstone MA, Albert DM. Prostaglandin-induced hair growth. Surv Ophthalmol 2002;47:S185-202. (Pubitemid 35232233)
10. Johnstone MA. Hypertrichosis and increased pigmentation of eyelashes and adjacent hair in the region of the ipsilateral eyelids of patients treated with unilateral topical latanoprost. Am J Ophthalmol 1997;124:544-7. (Pubitemid 27425878)
11. Casson RJ, Selva D. Lash ptosis caused by latanoprost. Am J Ophthalmol 2005;139:932-3. (Pubitemid 40614793)
12. Mehta JS, Raman J, Gupta N, Thoung D. Cutaneous latanoprost in the treatment of alopecia areata. Eye 2003;17:444-6. (Pubitemid 36592389)
13. Mansberger SL, Cioffi GA. Eyelash formation secondary to latanoprost treatment in a patient with alopecia. Arch Ophthalmol 2000;118:718-9. (Pubitemid 30327353)
14. Coronel-Pérez IM, Rodríguez-Rey EM, Camacho-Martínez FM. Latanoprost in the treatment of eyelash alopecia in alopecia areata universalis. J Eur Acad Dermatol Venereol 2010;24:481-5.
15. Uno H, Zimbric ML, Albert DM, Stjernschantz J. Effect of latanoprost on hair growth in the bald scalp of the stump-tailed macacque: a pilot study. ActaDerm Venereol 2002;82:7-12. (Pubitemid 34450536)
16. Sasaki S, Hozumi Y, Kondo S. Influence of prostaglandin F2α and its analogues on hair regrowth and follicular melanogenesis in a murine model. Ext Dermatol 2005;14:323-8. (Pubitemid 40691653)
17. Wolf R, Matz H, Zalish M, Pollack A, Orion E. Prostaglandin analogs for hair growth: great expectations. Dermatol Online 2003;9:7.
18. Thibaut S, De Becker E, Caisey L, Baras D, Karatas S, Jammayrac O, et al. Human eyelash characterization. Br J Dermatol 2010;162:304-10.
19. Gassmueller J, Rowold E, Frase T, Hughes-Formella B. Validation of TrichoScan technology as a fully-automated tool for evaluation of hair growth parameters. Eur J Dermatol 2009;19:224-31.
20. Hoffmann R. TrichoScan: Ein neues Werkzeug für die digitale Haarzählung. Hautarzt 2002;53:798-804. (Pubitemid 36069812)
21. Hoffmann R. TrichoScan: what is new? Dermatology 2005;211:54-62. (Pubitemid 40911565)
22. Hoffmann R. TrichoScan: combined epiluminescence microscopy with digital image analysis for the measurement of hair growth in vivo. Eur J Dermatol 2001;11:362-8. (Pubitemid 32623336)
23. Olsen EA, Whiting D, Bergfeld W, Miller J, Hordinsky M, Wanser R, et al. A multicenter, randomized, placebo-controlled, double-blind clinical trial of a novel formulation of 5% minoxidil topical foam versus placebo in the treatment of androgenetic alopecia in men. J Am Acad Dermatol 2007;57:767-74. (Pubitemid 47553065)
24. Stough DB, Rao NA, Kaufman KD, Mitchell C. Finasteride improves male pattern hair loss in a randomized study in identical twins. Eur J Dermatol 2002;12:32-7. (Pubitemid 34131136)
25. Blume-Peytavi U, Kunte C, Krisp A, Garcia Bartels N, Ellwanger U, Hoffmann R. Comparison of the efficacy and safety of topical minoxidil and topical alfatradiol in the treatment of androgenetic alopecia in women. J Dtsch Dermatol Ges 2007;5:391-5.
26. Blume-Peytavi U, Hillmann K, Dietz E, Canfield D, Garcia Bartels N. A randomized, single-blind trial of 5% minoxidil foam once daily versus 2% minoxidil solution twice daily in the treatment of androgenetic alopecia in women. J Am Acad Dermatol 2011 doi: 10.1016/j.jaad.2010.09.724. Published online June 24, 2011.