Study on genipin: A new alternative natural crosslinking agent for fixing heterograft tissue

Korean Journal of Thoracic and Cardiovascular Surgery

Volumn 44, Issue 3, 2011, Pages 197-207

  Yoo, Jae Suk ^a   Kim, Yong Jin ^a   Kim, Soo Hwan ^b   Choi, Seung Hwa ^b  

^a Seoul National University Hospital   (South Korea)

^b Seoul National University Biomedical Research Institute   (South Korea)

Author keywords

Bioprosthesis; Glutaraldehyde; Pericardial patch; Xenograft

Indexed keywords

EID: 84859839567     PISSN: 2233601X     EISSN: 20936516     Source Type: Journal    
DOI: 10.5090/kjtcs.2011.44.3.197     Document Type: Article

References (18)

1. Gratzer PF, Pereira CA, Lee JM. Solvent environment modulates effects of glutaraldehyde crosslinking on tissue-derived biomaterials. J Biomed Mater Res 1996;31:533-43.
2. Kim KC, Choi YK, Kim SH, Kim YJ. Effect of diamine bridges using l-lysine in glutaraldehyde treated porcine pericardium. Korean J Thorac Cardiovasc Surg 2009;42:157-64.
3. Pathak CP, Adams AK, Simpson T, Phillips RE Jr, Moore MA. Treatment of bioprosthetic heart valve tissue with long chain alcohol solution to lower calcification potential. J Biomed Mater Res A 2004;69:140-4.
4. Sung HW, Huang RN, Huang LL, Tsai CC, Chiu CT. Feasibility study of a natural crosslinking reagent for biological tissue fixation. J Biomed Mater Res 1998;42:560-7.
5. Xi-xun Y, Fei L, Yuan-ting X, Chang-xiu W. In vitro study in the endothelial cell compatibility and endothelialization of genipin-crosslinked biological tissues for tissue-engineered vascular scaffolds. J Mater Sci Mater Med 2010;21:777-85.
6. Jastrzebska M, Wrzalik R, Kocot A, Zalewska-Rejdak J, Cwalina B. Raman spectroscopic study of glutaraldehyde-stabilized collagen and pericardium tissue. J Biomater Sci Polym Ed 2003;14:185-97.
7. Cho S, Kim YJ, Kim SH, Park JE, Kim WH. Comparison of the uniaxial tensile strength, elasticity and thermal stability between glutaraldehyde and glutaraldehyde with solvent fixation in xenograft cardiovascular tissue. Korean J Thorac Cardiovasc Surg 2009;42:165.
8. Nimni ME, Cheung D, Strates B, Kodama M, Sheikh K. Chemically modified collagen: a natural biomaterial for tissue replacement. J Biomed Mater Res 1987;21:741-71.
9. Webb CL, Benedict JJ, Schoen FJ, Linden JA, Levy RJ. Inhibition of bioprosthetic heart valve calcification with aminodiphosphonate covalently bound to residual aldehyde groups. Ann Thorac Surg 1988;46:309-16.
10. Akao T, Kobashi K, Aburada M. Enzymic studies on the animal and intestinal bacterial metabolism of geniposide. Biol Pharm Bull 1994;17:1573-6.
11. Sung HW, Huang RN, Huang LL, Tsai CC. In vitro evaluation of cytotoxicity of a naturally occurring cross-linking reagent for biological tissue fixation. J Biomater Sci Polym Ed 1999;10:63-78.
12. Tsai CC, Huang RN, Sung HW, Liang HC. In vitro evaluation of the genotoxicity of a naturally occurring crosslinking agent (genipin) for biologic tissue fixation. J Biomed Mater Res 2000;52:58-65.
13. Chang Y, Hsu CK, Wei HJ, et al. Cell-free xenogenic vascular grafts fixed with glutaraldehyde or genipin: in vitro and in vivo studies. J Biotechnol 2005;120:207-19.
14. Chang Y, Tsai CC, Liang HC, Sung HW. In vivo evaluation of cellular and acellular bovine pericardia fixed with a naturally occurring crosslinking agent (genipin). Biomaterials 2002;23:2447-57.
15. Somers P, De Somer F, Cornelissen M, et al. Genipin blues: an alternative non-toxic crosslinker for heart valves? J Heart Valve Dis 2008;17:682-8.
16. Huang LL, Sung HW, Tsai CC, Huang DM. Biocompatibility study of a biological tissue fixed with a naturally occurring crosslinking reagent. J Biomed Mater Res 1998;42:568-76.
17. Touyama R, Inoue K, Takeda Y, et al. Studies on the blue pigments produced from genipin and methylamine. II. On the formation mechanisms of brownish-red intermediates leading to the blue pigment formation. Chem Pharm Bull 1994;42:1571-8.
18. Chang Y, Tsai CC, Liang HC, Sung HW. Reconstruction of the right ventricular outflow tract with a bovine jugular vein graft fixed with a naturally occurring crosslinking agent (genipin) in a canine model. J Thorac Cardiovasc Surg 2001; 122:1208-18.