Novel potent dual inhibitors of CK2 and Pim kinases with antiproliferative activity against cancer cells

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 9, 2012, Pages 3327-3331

  Pierre, Fabrice ^a   Regan, Collin F ^a   Chevrel, Marie Claire ^a   Siddiqui Jain, Adam ^a   MacAlino, Diwata ^a   Streiner, Nicole ^a   Drygin, Denis ^a   Haddach, Mustapha ^a   O'Brien, Sean E ^a   Rice, William G ^a   Ryckman, David M ^a  

^a Cylene Pharmaceuticals   (United States)

Author keywords

Cancer; CK2; Kinase inhibitor; Multikinase inhibitors; Pim

Indexed keywords

6 (4H 1,2,4 TRIAZOL 3 YL)THIENO[3,2 C]QUINOLINE; 7 (4H 1,2,4 TRIAZOL 3 YL)BENZO[C][2,6]NAPHTHYRIDINE; CASEIN KINASE II; CX 4945; MULTIKINASE INHIBITOR; PALLADIUM; PIM KINASE; PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE; QUINOLINE DERIVATIVE; RECOMBINANT ENZYME; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CANCER THERAPY; CATALYSIS; CELL PROLIFERATION; CELL VIABILITY; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; CLINICAL TRIAL (TOPIC); DRUG EFFECT; DRUG POTENCY; DRUG TARGETING; ENZYME ASSAY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE; GROWTH INHIBITION; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CASEIN KINASE II; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG DISCOVERY; HUMANS; INHIBITORY CONCENTRATION 50; NEOPLASMS; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-PIM-1;

EID: 84859838952     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.02.099     Document Type: Article

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