Elevated inflammatory markers at preschool age precede persistent wheezing at school age

Pediatric Allergy and Immunology

Volumn 23, Issue 3, 2012, Pages 259-264

  van de Kant, Kim D G ^a   Jansen, Maria A ^a   Klaassen, Ester M M ^a   van der Grinten, Chris P ^a   Rijkers, Ger T ^b,c   Muris, Jean W M ^a   van Schayck, Onno C P ^a   Jöbsis, Quirijn ^a   Dompeling, Edward ^a  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c ST ANTONIUS HOSPITAL   (Netherlands)

Author keywords

Airway resistance; Asthma; Exhaled breath condensate; Phenotypes; Preschool wheeze

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CORTICOSTEROID; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 8;

AIRWAY; ARTICLE; ATOPY; BREATH ANALYSIS; BRONCHODILATATION; CHILD; CONTROLLED STUDY; ECZEMA; FEMALE; HUMAN; IMMUNOASSAY; LUNG FUNCTION TEST; LUNG RESISTANCE; MAJOR CLINICAL STUDY; MALE; PATIENT ASSESSMENT; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; RESPIRATORY TRACT EXAMINATION; WHEEZING;

AIRWAY RESISTANCE; BIOLOGICAL MARKERS; CHILD; CHILD, PRESCHOOL; EXHALATION; FEMALE; HUMANS; INFLAMMATION; INTERLEUKINS; MALE; PHENOTYPE; RESPIRATORY SOUNDS; SCHOOLS; UP-REGULATION;

EID: 84859837377     PISSN: 09056157     EISSN: 13993038     Source Type: Journal    
DOI: 10.1111/j.1399-3038.2011.01244.x     Document Type: Article

References (23)

1. Martinez FD, Wright AL, Taussig LM, Holberg CJ, Halonen M, Morgan WJ. Asthma and wheezing in the first six years of life. The Group Health Medical Associates. N Engl J Med 1995: 332: 133-8.
2. Henderson J, Granell R, Sterne J. The search for new asthma phenotypes. Arch Dis Child 2009: 94: 333-6.
3. Spycher BD, Silverman M, Kuehni CE. Phenotypes of childhood asthma: are they real? Clin Exp Allergy 2010: 40: 1130-41.
4. Pijnenburg MW, de Jongste JC. Exhaled nitric oxide in childhood asthma: a review. Clin Exp Allergy 2008: 38: 246-59.
5. Rosias PP, Robroeks CM, van de Kant KD, et al. Feasibility of a new method to collect exhaled breath condensate in pre-school children. Pediatr Allergy Immunol 2010: 21: e235-44.
6. van de Kant KD, Klaassen EM, Jöbsis Q, et al. Wheezing in preschool children is associated with increased levels of cytokines/chemokines in exhaled breath condensate. J Allergy Clin Immunol 2010: 126: 669-71.
7. Oommen A, Patel R, Browning M, Grigg J. Systemic neutrophil activation in acute preschool viral wheeze. Arch Dis Child 2003: 88: 529-31.
8. McDougall CM, Helms PJ. Neutrophil airway inflammation in childhood asthma. Thorax 2006: 61: 739-41.
9. Marguet C, Jouen-Boedes F, Dean TP, Warner JO. Bronchoalveolar cell profiles in children with asthma, infantile wheeze, chronic cough, or cystic fibrosis. Am J Respir Crit Care Med 1999: 159: 1533-40.
10. Shahid SK, Kharitonov SA, Wilson NM, Bush A, Barnes PJ. Increased interleukin-4 and decreased interferon-gamma in exhaled breath condensate of children with asthma. Am J Respir Crit Care Med 2002: 165: 1290-3.
11. Merkus PJ, Stocks J, Beydon N, et al. Reference ranges for interrupter resistance technique: the asthma UK initiative. Eur Respir J 2010: 36: 157-63.
12. Brussee JE, Smit HA, Koopman LP, et al. Interrupter resistance and wheezing phenotypes at 4years of age. Am J Respir Crit Care Med 2004: 169: 209-13.
13. Kooi EM, Schokker S, van der Molen T, Duiverman EJ. Airway resistance measurements in pre-school children with asthmatic symptoms: the interrupter technique. Respir Med 2006: 100: 955-64.
14. Oostveen E, Dom S, Desager K, Hagendorens M, De Backer W, Weyler J. Lung function and bronchodilator response in 4-year-old children with different wheezing phenotypes. Eur Respir J 2010: 35: 865-72.
15. The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee. Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. Lancet 1998: 351: 1225-32.
16. van de Kant KD, Klaassen EM, Jöbsis Q, Nijhuis AJ, van Schayck OC, Dompeling E. Early diagnosis of asthma in young children by using non-invasive biomarkers of airway inflammation and early lung function measurements: study protocol of a case-control study. BMC Public Health 2009: 9: 210.
17. De Jager W, Te Velthuis H, Prakken BJ, Kuis W, Rijkers GT. Simultaneous detection of 15 human cytokines in a single sample of stimulated peripheral blood mononuclear cells. Clin Diagn Lab Immunol 2003: 10: 133-9.
18. Robroeks CM, Rijkers GT, Jöbsis Q, et al. Increased cytokines, chemokines and soluble adhesion molecules in exhaled breath condensate of asthmatic children. Clin Exp Allergy 2010: 40: 77-84.
19. Martinez FD, Godfrey S. Immunology of wheezing disorders in infants and preschool children. New York: Martin Dunitz, 2003.
20. Beydon N, Davis SD, Lombardi E, et al. An official American Thoracic Society/European Respiratory Society statement: pulmonary function testing in preschool children. Am J Respir Crit Care Med 2007: 175: 1304-45.
21. Caudri D, Wijga AH, Hoekstra MO, et al. Prediction of asthma in symptomatic preschool children using exhaled nitric oxide, Rint and specific IgE. Thorax 2010: 65: 801-7.
22. Horvath I, Hunt J, Barnes PJ, et al. Exhaled breath condensate: methodological recommendations and unresolved questions. Eur Respir J 2005: 26: 523-48.
23. Rosias PP, Robroeks CM, Kester A, et al. Biomarker reproducibility in exhaled breath condensate collected with different condensers. Eur Respir J 2008: 31: 934-42.