Utility, or not, of estimates of glomerular filtration rate in modifying drug dosage, with particular reference to enoxaparin

Internal Medicine Journal

Volumn 42, Issue 4, 2012, Pages 463-466

  Adam, W R ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Drug toxicity; Enoxaparin; GFR; Pharmacodynamics; Renal failure

Indexed keywords

CREATININE; ENOXAPARIN;

ANTHROPOMETRY; ARTICLE; CLINICAL DECISION MAKING; CREATININE CLEARANCE; DRUG BLOOD LEVEL; DRUG CHOICE; GLOMERULUS FILTRATION RATE; HIGH RISK PATIENT; HUMAN; KIDNEY FAILURE; KIDNEY FUNCTION; PHARMACODYNAMICS; PRIORITY JOURNAL; URINALYSIS; URINARY EXCRETION;

DRUG DOSAGE CALCULATIONS; ENOXAPARIN; GLOMERULAR FILTRATION RATE; HUMANS; KIDNEY; MEDICAL ERRORS; RENAL INSUFFICIENCY;

EID: 84859837236     PISSN: 14440903     EISSN: 14455994     Source Type: Journal    
DOI: 10.1111/j.1445-5994.2012.02742.x     Document Type: Article

References (20)

1. McNeill GBS, Martin JH. How reliable is eGFR when calculating drug dosage in acute medical admissions? Intern Med J 2011; 41: 327-31.
2. Froissart M, Rossert J, Jacquot C, Paillard M, Houillier P. Predictive performance of the modification of diet in renal disease and Cockcroft-Gault equations for estimating renal function. J Am Soc Nephrol 2005; 16: 763-73.
3. Coresh J, Stevens LA. Kidney function estimating equations: where do we stand. Curr Opin Nephrol Hypertens 2006; 15: 276-84.
4. Stevens LA, Coresh J, Greene T, Levey AS. Assessing kidney function - measured and estimated glomerular filtration rate. N Engl J Med 2006; 354: 2473-83.
5. Sterner G, Frennby B, Mansson S, Nyman U, Van Westen D, Almen T. Determining 'true' glomerular filtration rate in healthy adults using infusion of inulin and comparing it with values obtained using other clearance techniques or prediction equations. Scand J Urol Nephrol 2008; 42: 278-85.
6. Coresh J, Toto RD, Kirk KA, Whelton PK, Massry S, Jones C etal. Creatinine clearance as a measure of GFR in screenees for the African-American Study of Kidney Disease and Hypertension pilot study. Am J Kidney Dis 1998; 32: 32-42.
7. Hilbrands LB, Artz MA, Wetzels JFM, Koene RAP. Cimetidine improves the reliability of creatinine as a marker of glomerular filtration. Kidney Int 1991; 40: 1171-6.
8. Verhave JC, Balje-Volkers CP, Hillege HL, De Zeeuw D, De Jong PE. The reliability of different formulae to predict creatinine clearance. J Intern Med 2003; 253: 563-73.
9. Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF 3rd, Feldman HI etal. A new equation to estimate glomerular filtration rate. Ann Intern Med 2009; 150: 604-12.
10. Grootendorst DC, Michels WM, Richardson JD, Jager KJ, Boeschoten EW, Dekker FW etal. The MDRD formula does not reflect GFR in ESRD patients. Nephrol Dial Transplant 2011; 26: 1932-7.
11. Gallagher D, Visser M, De Meersman RE, Sepulveda D, Baumgartner RN, Pierson RN etal. Appendicular skeletal muscle mass: effects of age, gender and ethnicity. J Appl Physiol 1997; 83: 229-39.
12. Adam WR. Chronic kidney disease and automatic reporting of estimated glomerular filtration rate: revised recommendations. Med J Aust 2008; 188: 427-8.
13. Martin JH, Fay MF, Udy A, Roberts J, Kirkpatrick C, Ungerer J etal. Pitfalls of using estimations of glomerular filtration rate in an intensive care population. Intern Med J 2011; 41: 537-42.
14. Brown MA, Pirabhahar S, Kelly JJ, Mangos GJ, Mackenzie C, McConachie P etal. Inaccuracies in estimated glomerular filtration rate in one Australian renal centre. Nephrology (Carlton) 2011; 16: 486-94.
15. LOVENOX. LOVENOX dosing-proven outcomes in surgery. Updated 2010 Mar [cited 18 May 2011]. Available from URL:
16. Green B, Greenwood M, Saltissi D, Westhuyzen J, Kluver L, Rowell J etal. Dosing strategy for enoxaparin in patients with renal impairment presenting with acute coronary syndromes. Br J Clin Pharmacol 2005; 59: 281-90.
17. Lim W, Dentali F, Eikelboom JW, Crowther MA. Meta-analysis: low-molecular-weight heparin and bleeding in patients with severe renal insufficiency. Ann Intern Med 2006; 144: 673-84.
18. Cervelli MJ, ed. The Renal Drug Reference Guide. Adelaide: Kidney Health Australia; 2007.
19. Stevens LA, Coresh J, Schmid CH, Feldman HI, Froissart M, Kusek J etal. Estimating GFR using serum cystatin C alone and in combination with serum creatinine: a pooled analysis of 3, 418 individuals with CKD. Am J Kidney Dis 2008; 51: 395-406.
20. Eyler RF, Mueller BA. Antibiotic dosing in critically ill patients with acute kidney injury. Nat Rev Nephrol 2011; 7: 226-35.