Reactive oxygen species: The achilles' heel of Cancer cells?

Antioxidants and Redox Signaling

Volumn 16, Issue 11, 2012, Pages 1212-1214

  Cui, Xiaojiang ^a  

^a Samuel Oschin Comprehensive Cancer Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ANGIOGENESIS; CANCER CELL; CANCER STEM CELL; CARCINOGENESIS; EPITHELIAL MESENCHYMAL TRANSITION; METASTASIS; MOLECULARLY TARGETED THERAPY; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; STROMA CELL;

EPITHELIAL-MESENCHYMAL TRANSITION; GENES, P53; HUMANS; NADPH OXIDASE; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; REACTIVE OXYGEN SPECIES;

EID: 84859833047     PISSN: 15230864     EISSN: 15577716     Source Type: Journal    
DOI: 10.1089/ars.2012.4532     Document Type: Review

References (9)

1. Coso S, Harrison I, Harrison CB, Vinh A, Sobey C, Drummond GR, Williams E, and Selemidis S. NADPH oxidases as regulators of tumor angiogenesis: current and emerging concepts. Antioxid Redox Signal 16: 1229-1247, 2012.
2. Diehn M, Cho RW, Lobo NA, Kalisky T, Dorie MJ, Kulp AN, Qian D, Lam JS, Ailles LE, Wong M, Joshua B, Kaplan MJ, Wapnir I, Dirbas FM, Somlo G, Garberoglio C, Paz B, Shen J, Lau SK, Quake SR, Brown JM, Weissman IL, and Clarke MF. Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature 458: 780-783, 2009.
3. Giannoni E, Parri M, and Chiarugi P. EMT and oxidative stress: a bidirectional interplay affecting tumor malignancy. Antioxid Redox Signal 16: 1248-1263, 2012.
4. Gupta SC, Hevia D, Patchva S, Park B, Koh W, and Aggarwal BB. Upsides and downsides of reactive oxygen species for cancer: the roles of reactive oxygen species in tumorigenesis, prevention, and therapy. Antioxid Redox Signal 16: 1295-1322, 2012.
5. Kalluri R and Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest 119: 1420-1428, 2009.
6. Levine AJ. p53, the cellular gatekeeper for growth and division. Cell 88: 323-331, 1997.
7. Maillet A and Pervaiz S. Redox regulation of p53, redox effectors regulated by p53: a subtle balance. Antioxid Redox Signal 16: 1285-1294, 2012.
8. Pavlides S, Vera I, Gandara R, Sneddon S, Pestell RG, Mercier I, Martinez-Outschoorn UE, Whitaker-Menezes D, Howell A, Sotgia F, and Lisanti MP. Warburg meets autophagy: cancerassociated fibroblasts accelerate tumor growth and metastasis via oxidative stress, mitophagy, and aerobic glycolysis. Antioxid Redox Signal 16: 1264-1284, 2012.
9. Shi X, Zhang Y, Zheng J, and Pan J. Reactive oxygen species in cancer stem cells. Antioxid Redox Signal 16: 1215-1228, 2012.