Fungal melanonychia

Journal of the American Academy of Dermatology

Volumn 66, Issue 5, 2012, Pages 830-841

  Finch, Justin ^a   Arenas, Roberto ^b   Baran, Robert ^c  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b HOSPITAL GENERAL DR MANUEL GEA GONZÁLEZ   (Mexico)

^c NAIL DISEASE CENTRE   (France)

Author keywords

Alternaria; dematiaceous fungi; dermatomycosis; fungal melanin; fungal melanonychia; fungus; Hendersonula toruloidea; melanonychia; nail; Nattrassia mangiferae; onychomycosis; phaeohyphomycosis; pigmented nail infection; Scytalidium; Trichophyton rubrum; ungual phaeohyphomycosis

Indexed keywords

AMPHOTERICIN B; BIFONAZOLE; CICLOPIROX; ITRACONAZOLE; MELANIN; TERBINAFINE; VORICONAZOLE;

ALTERNARIA; CLINICAL FEATURE; DERMATOMYCOSIS; DIFFERENTIAL DIAGNOSIS; EXOPHIALA; FUNGAL MELANONYCHIA; FUNGAL MELONONYCHIA; FUNGUS; FUNGUS CULTURE; GEOGRAPHIC DISTRIBUTION; HUMAN; HYPERTHERMIC THERAPY; MELANOMA; MICROSCOPY; NAIL COLOR; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; SCYTALIDIUM DIMIDIATUM; TRICHOPHYTON RUBRUM;

ARTHRODERMATACEAE; COMBINED MODALITY THERAPY; DERMOSCOPY; FEMALE; FOOT DERMATOSES; FUNGEMIA; FUNGI; HAND DERMATOSES; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MELANOSIS; ONYCHOMYCOSIS; PROGNOSIS; RARE DISEASES; RISK ASSESSMENT; YEASTS;

EID: 84859827783     PISSN: 01909622     EISSN: 10976787     Source Type: Journal    
DOI: 10.1016/j.jaad.2010.11.018     Document Type: Review

References (97)

1. Tosti A, Piraccini BM, Lorenzi S. Onychomycosis caused by nondermatophytic molds: clinical features and response to treatment of 59 cases. J Am Acad Dermatol 2000;42:217-24. (Pubitemid 30469618)
2. Badillet G. Mélanonychies superficielles. Bulletin de la Societe Française de Mycologie Medicale 1988;17:335-40.
3. Brandt ME, Warnock DW. Epidemiology, clinical manifestations, and therapy of infections caused by dematiaceous fungi. J Chemother 2003;15(Suppl):36-47. (Pubitemid 38021614)
4. Hay RJ, Moore MK. Clinical features of superficial fungal infections caused by Hendersonula toruloidea and Scytalidium hyalinum. Br J Dermatol 1984;110:677-83. (Pubitemid 14084050)
5. Sharma NL, Mahajan V, Sharma RC, Sharma A. Subcutaneous pheohyphomycosis in India - a case report and review. Int J Dermatol 2002;41:16-20. (Pubitemid 34192969)
6. Kotrajaras R, Chongsathein S, Rojanavich V, Buddhavudhikrai P, Viriyayudhakorn S. Hendersonula toruloidea infection in Thailand. Int J Dermatol 1988;27:391-5.
7. Costa AR, Porto E, Lacaz CS, de Melo NT, Calux Mde J, Valente NY. Cutaneous and ungual phaeohyphomycosis caused by species of Chaetomium Kunze (1817) ex Fresenius, 1829. J Med Vet Mycol 1988;26:261-8. (Pubitemid 19077309)
8. Little MG, Hammond ML. Scytalidium dimidiatum in Australia. Australas J Dermatol 1995;36:204-5.
9. Arrese JE, Piérard-Franchimont C, Piérard-Gerald E. Onychomycosis and keratomycosis caused by Alternaria sp.: a bipolar opportunistic infection in a wood-pulp worker on chronic steroid therapy. Am J Dermatol 1996;18:611-3. (Pubitemid 27020176)
10. Singh SM, Pouranik M. Ungual and cutaneous phaeohyphomycosis caused by Alternaria alternata and Alternaria chlamydospora. J Med Vet Mycol 1990;28:275-8. (Pubitemid 20387363)
11. Romano C, Paccagnini E, Difonzo EM. Onychomycosis caused by Alternaria spp. in Tuscany, Italy from 1985 to 1999. Mycoses 2001;44:73-6.
12. Wadhwani K, Shrivastava AK. Some cases of onychomycosis from North India in different working environments. Mycopathologica 1985;92:149-55. (Pubitemid 16200279)
13. Romano C, Gianni C, Difonzo EM. Retrospective study of onychomycosis in Italy: 1985-2000. Mycoses 2005;48:42.
14. Lacroix C, Kac G, Dubertret L, Morel P, Derouin F, de Chauvin MF. Scytalidiosis in Paris, France. J Am Acad Dermatol 2003;48: 852-6. (Pubitemid 36706216)
15. Moore MK. Hendersonula toruloidea and Scytalidium hyalinum infections in London, England. J Med Vet Mycol 1986;24: 219-30. (Pubitemid 16094414)
16. Kombila M, Martz M, Gomez de Diaz M, de Bievre C, Richard-Lenoble D. Hendersonula toruloidea as an agent of mycotic foot infection in Gabon. J Med Vet Mycol 1990;28: 215-23. (Pubitemid 20296496)
17. Allison VY, Hay RJ, Campbell CK. Hendersonula toruloidea and Scytalidium hyalinum infections in Tobago. Br J Dermatol 1984; 111:371-2.
18. Moore MK. Skin and nail infections by nondermatophyte filamentous fungi. Mykosen Suppl 1978;1:128-32.
19. Matsumoto T, Matsuda T, Padhye AA, Standard PG, Ajello L. Fungal melanonychia: ungual phaeohyphomycosis caused by Wangiella dermatitidis. Clin Exp Dermatol 1992;17:83-6.
20. Baran R, Tosti A, Piraccini BM. Uncommon clinical patterns of Fusarium nail infection: report of three cases. Br J Dermatol 1997;136:424-7. (Pubitemid 27105873)
21. Vierira JR. Onychomycose por Aureobasidium pullulans (De Bary) Arnaud. Proceedings of the Congress for Tropical Medicine and Malaria 1961;4:768-77.
22. Male O, Trappeiner J. Nagelveranderungen durch Schimmelpilze. Dermatologische Wochenschrift 1965;151:212-21.
23. Gip L, Paldrock H. Onychomycosis caused by Phyllostictina sydow. Acta Derm Venereol 1967;47:186-9.
24. Badillet G, Panagiotidou D, Sene S. Etude retrospective des Trichophyton rubrum á pigment noir diffusible isolés á Paris de 1971 á 1980. Bulletin de la Societe Française de Mycologie Medicale 1984;1:117-20.
25. Baxter M. The stimulation of pigment production by Trichophyton rubrum on a new medium. Sabouraudia 1963;3: 72-80.
26. Ray AC, Eakin RE. Studies on the biosynthesis of aspergillin by Aspergillus niger. Appl Microbiol 1975;30:909-15.
27. Finch JJ, Warshaw EM. Toenail onychomycosis: current and future treatment options. Dermatol Ther 2007;20:31-46. (Pubitemid 46568375)
28. Parlak AH, Goksugur N, Karabay O. A case of melanonychia due to Candida albicans. Clin Dermatol 2006;31:398-400.
29. Velez A. Melanonychia due to Candida humicola. Br J Dermatol 1996;134:374-5.
30. Gautret P, Rodier MH, Kauffmann-Lacroix C, Jacquemin JL. Case report and review: onychomycosis due to Candida parapsilosis. Mycoses 2000;43:433-5. (Pubitemid 32055286)
31. Lee SW, Kim YC, Kim DK, Yoon TY, Park HJ, Cinn YW. Fungal melanonychia. J Dermatol 2004;31:904-9. (Pubitemid 39612225)
32. Morris-Jones R, Gomez BL, Diez S, Uran M, Morris-Jones SD, Casadevall A, et al. Synthesis of melanin pigment by Candida albicans in vitro and during infection. Infect Immun 2005;73: 6147-50. (Pubitemid 41193055)
33. Lyke KE, Miller NS, Towne L, Merz WG. A case of cutaneous ulcerative alternariosis: rare association with diabetes mellitus and unusual failure of itraconazole treatment. Clin Infect Dis 2001;32:1178-87. (Pubitemid 32396399)
34. Taylor BE, Wheeler MH, Szaniszlo PJ. Evidence for pentaketide melanin biosynthesis in dematiaceous human pathogenic fungi. Mycologia 1987;79:320-2.
35. Nosanchuk JD, Rosas AL, Casadevall A. The antibody response to fungal melanin in mice. J Immunol 1998;160:6026-31. (Pubitemid 28298065)
36. Polak A. Melanin as a virulence factor in pathogenic fungi. Mycoses 1989;33:215-24.
37. Bell AA, Wheeler MH. Biosynthesis and functions of fungal melanins. Ann Rev Phytopathol 1986;24:411-51.
38. Mirchink TG, Kashkina GB, Abatwrow YND. The resistance of fungi with various pigments to gamma radiation. Microbiology USSR 1972;41:67-9.
39. Wheeler MH, Bell AA. Melanins and their importance in pathogenic fungi. In: McGinnis MR, editor. Current topics in medical mycology, Vol 2. New York: Springer Verlag, 1988. pp. 338-387.
40. Bloomfield BJ, Alexander M. Melanins and resistance of fungi to lysis. J Bacteriol 1967;93:1276-80.
41. Kubo Y, Suzuki K, Furusawa I, Yamamoto M. Melanin biosynthesis as a prerequisite for penetration by appressoria of Colletotrichum lagenarium: site of inhibition by melanin-inhibiting fungicides and their action on appressoria. Pestic Biochem Physiol 1985;23:47-55. (Pubitemid 15159245)
42. Hamilton AJ, Holdom MD. Antioxidant systems in the pathogenic fungi of man and their role in virulence. Med Mycol 1999;37:375-89. (Pubitemid 30006560)
43. Scnitzler N, Peltroche-Llacsahuanga H, Bestier N, Zündorf J, Lütticken R, Haase G. Effect of melanin and carotenoids of Exophiala (Wangiella) dermatitidis on phagocytosis, oxidative burst, and killing by human neutrophils. Infect Immun 1999; 67:94-101. (Pubitemid 29021634)
44. Jacobson ES, Hove E, Emery HS. Antioxidant function of melanin in black fungi. Infect Immun 1995;63:4944-5.
45. Jacobson ES. Redox buffering by melanin and Fe(II) in Cryptococcus neoformans. J Bacteriol 1997;179:5340-6. (Pubitemid 27387601)
46. Dixon DM, Polak A, Szaniszlo PJ. Pathogenicity and virulence of wild-type and melanin-deficient Wangiella dermatitidis. J Med Vet Mycol 1987;25:97-106.
47. Badillet G, Panagiotidou D, Coco O, Sené S. Etude des souches de Trichophyton rubrum à pigment noir diffusible isolés en 1982-83 à Paris et à Salonique. Bulletin de la Societe Française de Mycologie Medicale 1984;1:121-4.
48. Perrin C, Baran R. Longitudinal melanonychia caused by Trichophyton rubrum: histochemical and ultrastructural studies of two cases. J Am Acad Dermatol 1994;31:311-6. (Pubitemid 24249255)
49. Haneke E. Fungal infections of the nail. Semin Dermatol 1991; 10:41-53.
50. Lateur N, André J. Melanonychia: diagnosis and treatment. Dermatol Ther 2002;15:131-41. (Pubitemid 34832668)
51. Glowacka A, Wasowska-Krolikowska K, Skowron-Kobos J, Kurnatowski M, Janniger CK. Childhood onychomycosis: alternariosis of all ten fingernails. Pediatr Dermatol 1998;62:125-8. (Pubitemid 128472650)
52. Campbell CK, Kurwa A, Abdel-Aziz AM, Hodgson C. Fungal infection of skin and nails by Hendersonula toruloidea. Br J Dermatol 1973;89:45.
53. Meisel EC, Quadripur SA. Onychomycosis due to Hendersonula toruloidea. Hautnah Mykologie 1992;6:232-4.
54. Gupta AK, Ryder JE, Baran R, Summerbell RC. Non-dermatophyte onychomycosis. Dermatol Clin 2003;21:257-68. (Pubitemid 36529759)
55. Tosti A, Piraccini BM. Proximal subungual onychomycosis due to Aspergillus niger: report of two cases. Br J Dermatol 1998; 139:152-69.
56. Braun RP, Baran R, Le Gal FA, Dalle S, Ronger S, Pandolfi R, et al. Diagnosis and management of nail pigmentations. J Am Acad Dermatol 2007;56:835-47. (Pubitemid 46561013)
57. Baran R. Nail biting and picking as a possible cause of longitudinal melanonychia: a study of 6 cases. Dermatologica 1990;181:126-8. (Pubitemid 20263281)
58. Baran R. Frictional longitudinal melanonychia: a new entity. Dermatologica 1987;174:280-4. (Pubitemid 17075440)
59. Skowron F, Combemale P, Faisant M, Baran R, Kanitakis J, Dupin M. Functional melanonychia due to involvement of the nail matrix in systemic lupus erythematosus. J Am Acad Dermatol 2002;47(Suppl):S187-8.
60. Aste N, Fumo G, Contu F, Aste N, Biggio P. Nail pigmentation caused by hydroxyurea: report of 9 cases. J Am Acad Dermatol 2002;47:146-7.
61. Ledbetter LS, Hsu S. Melanonychia associated with PUVA therapy. J Am Acad Dermatol 2003;48(Suppl):S31-2. (Pubitemid 36231884)
62. Fryer JM, Werth VP. Pregnancy-associated hyperpigmentation: longitudinal melanonychia. JAmAcad Dermatol 1992;26:493-4.
63. Dasanu CA, Vaillant JG, Alexandrescu DT. Distinct patterns of chromonychia, Beau's lines, and melanoderma seen with vincristine, Adriamycin, dexamethasone therapy for multiple myeloma. Dermatol Online J 2006;12:10.
64. Haneke E, Baran R. Longitudinal melanonychia. Dermatol Surg 2001;27:580-4. (Pubitemid 32552914)
65. Tosti A, Baran R, Piraccini BM, Cameli N, Fanti PA. Nail matrix nevi: a clinical and histopathological study of twenty-two patients. J Am Acad Dermatol 1996;34:765-71. (Pubitemid 26137200)
66. Baran R, Haneke D, Drape JL, Zook EG. Tumors of the nail apparatus and adjacent tissues. In: Baran R, Dawber RPR, de Berker DAR, et al, editors. Baran and Dawber's diseases of the nails and their management. 3rd ed Oxford: Blackwell Science; 2001. pp. 607-30.
67. Thomas L, Dalle S. Dermoscopy provides useful information for the management of melanonychia striata. Dermatol Ther 2007;20:3-10. (Pubitemid 46568372)
68. Di Chiacchio N, Hirata SH, Enokihara MY, Michalany NS, Fabbrocini G, Tosti A. Dermatologists' accuracy in early diagnosis of melanoma of the nail matrix. Arch Dermatol 2010;146: 382-7.
69. English MP. Nails and fungi. Br J Dermatol 1976;94:697-701.
70. Arrese JE, Piérard-Franchimont C, Greimers R, Piérard- Gerald E. Fungi in onychomycosis: a study by immunohistochemistry and dual flow cytometry. J Eur Acad Dermatol Venereol 1995; 4:123-30.
71. De Doncker PR, Scher RK, Baran RL, Decroix J, Degreef HJ, Roseeuw DI, et al. Itraconazole therapy is effective for pedal onychomycosis caused by some nondermatophyte molds and in mixed infection with dermatophytes and molds: a multicenter study with 36 patients. J Am Acad Dermatol 1997;36: 173-7. (Pubitemid 27078906)
72. Larsen CG, Arendrup MC, Krarup E, Pedersen M, Thybo S, Larsen FG. Subcutaneous phaeohyphomycosis in a renal transplant recipient successfully treated with voriconazole. Acta Derm Venereol 2009;89:657-8.
73. Elewski BE. Onychomycosis caused by Scytalidium dimidiatum. J Am Acad Dermatol 1996;35:338.
74. Rollman O, Johansson S. Hendersonula toruloidea infection-successful response of onychomycosis to nail avulsion and topical ciclopiroxolamine. Acta Derm Venereol 1987; 67:506-10. (Pubitemid 18014097)
75. Sigler L, Summerbell RC, Poole L, Wieden M, Sutton DA, Rinaldi MG, et al. Invasive Nattrassia mangiferae infections: case report, literature review, andtherapeutic and taxonomic appraisal. J Clin Microbiol 1997;35:433-40. (Pubitemid 27043918)
76. Gianni C, Romano C. Clinical and histological aspects of toenail onychomycosis caused by Aspergillus spp.: 34 cases treated with weekly intermittent terbinafine. Dermatology 2004;209:104-10. (Pubitemid 39179079)
77. Young WJ. Pigmented mycotic growth beneath the nails. Arch Dermatol 1934;30:186-9.
78. Gianni C, Cerri A, Crosti C. Ungual phaeohyphomycosis caused by Alternaria alternata. Mycoses 1997;40:219-21. (Pubitemid 28018496)
79. Pritchard RC, Muir DB. Black fungi: a survey of dematiaceous hyphomycetes from clinical specimens identified over a five year period in a reference laboratory. Pathology 1987;19: 281-4. (Pubitemid 17132306)
80. Ernst TM. Nagel-alternariose. Mykosen 1983;26:553-6. (Pubitemid 14189613)
81. Restrepo A, Arango M, Velez H, Uribe L. The isolation of Botryodiplodia theobromae from a nail lesion. Sabouraudia 1976;14:1-4.
82. Barde AK, Singh SM. Cladosporium carrionii Trejos 1954 infection of human nail. Mykosen 1984;27:366-9. (Pubitemid 14070185)
83. Badillet G, de Biévre C, Spizajzen S. Isolement de dématées a partir d'ongles et de squames. Bulletin de la Societe Française de Mycologie Medicale 1982;11:69-72.
84. Barde AK, Singh SM. A case of onychomycosis caused by Curvularia lunata (Wakker) Boedijn. Mykosen 1983;26:311-6. (Pubitemid 13025555)
85. Boisseau-Garsaud A, Desbois N, Guillermin M, Ossondo M, Gueho E, Cales-Quist D. Onychomycosis due to Exophiala jeanselmei. Dermatology 2002;204:150-2. (Pubitemid 34297983)
86. Hata Y, Naka W, Nishikawa T. A case of melanonychia caused by Exophiala dermatitidis. Nippon Ishinkin Gakkai Zasshi 1999; 40:231-4.
87. Ritchie EB, Pinkerton ME. Fusarium oxysporum infection of the nail. Arch Dermatol 1959;79:705-8.
88. Arrese JE, Piérard-Franchimont C, Piérard-Gerald E. Fatal hyalohyphomycosis following Fusarium onychomycosis in an immunocompromised patient. Am J Dermatol 1996;18:196-8. (Pubitemid 26127841)
89. Baran R, Kechijian P. Longitudinal melanonychia (melanonychia striata): diagnosis and management. J Am Acad Dermatol 1989;21:1165-75. (Pubitemid 20216983)
90. Punithalingam E, English MP. Pyrenochaeta unguis-hominis sp.nov. on human toenails. Transactions of the British Mycological Society 1975;64:539-41.
91. Carruthers JA, Stein L, Black WA. Persistent skin and nail infection by an exotic fungus, Hendersonula toruloidea. Can Med Assoc J 1982;127:608. (Pubitemid 12000820)
92. Gentles JC, Evans EGV. Infection of the feet and nails with Hendersonula toruloidea. Sabouraudia 1970;8:72-5.
93. Arrese JE, Piérard-Franchimont C, Piérard GE. Scytalidium dimidiatum melanonychia and scaly plantar skin in four patients from the Maghreb: imported disease or outbreak in a Belgian mosque? Dermatology 2001;202:183-5. (Pubitemid 32337181)
94. Lacaz CS, Pereira AD, Heins-Vaccari EM, Cucé LC, Benatti C, Nunes RS, et al. Onychomycosis caused by Scytalidium dimidiatum: report of two cases; review of the taxonomy of the synanamorph and anamorph forms of this coelomycete. Rev Inst Med Trop Sao Paulo 1999;41:319-23.
95. Elewski BE, Greer DL. Hendersonula toruloidea and Scytalidium hyalinum: review and update. Arch Dermatol 1991;127: 1041-4.
96. Peiris S, Moore MK, Marten RH. Scytalidium dimidiatum infection of the skin and nails. Br J Dermatol 1979;100:579-84. (Pubitemid 9255469)
97. Kalter DC, Hay RJ. Onychomycosis due to Trichophyton soudanense. Clin Exp Dermatol 1988;13:221-7.