Conformationally restricted novel pyrazole derivatives: Synthesis of 1,8-disubstituted 5,5-dimethyl-4,5-dihydro-1H-benzo[g]indazoles as a new class of PDE4 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 9, 2012, Pages 3248-3255

  Shyamsunder Reddy, T ^a,e   Shiva Kumar, K ^b   Meda, Chandana L T ^b   Kandale, Ajit ^b   Rambabu, D ^b,c   Rama Krishna, G ^d   Hariprasad, C ^a   Venugopala Rao, V ^a   Venkataiah, S ^a   Malla Reddy, C ^d   Naidu, A ^e   Dubey, P K ^e   Parsa, Kishore V L ^b   Pal, Manojit ^b  

^a IDA Jeedimetla   (India)

^b INSTITUTE OF LIFE SCIENCES   (India)

^c K L UNIVERSITY   (India)

^d INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH KOLKATA   (India)

^e JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY   (India)

Author keywords

Benzo g indazole; Docking; PDE4; Pyrazole; X ray

Indexed keywords

1,8 DISUBSTITUTED 5,5 DIMETHYL 4,5 DIHYDRO 1H BENZO[G]INDAZOLE DERIVATIVE; PHOSPHODIESTERASE IV INHIBITOR; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; MOLECULAR MODEL;

CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; INDAZOLES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PHOSPHODIESTERASE 4 INHIBITORS; PYRAZOLES;

EID: 84859812794     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.03.029     Document Type: Article

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