Peptide truncation leads to a twist and an unusual increase in affinity for casitas B-lineage lymphoma tyrosine kinase binding domain

Journal of Medicinal Chemistry

Volumn 55, Issue 7, 2012, Pages 3583-3587

  Kumar, Eric A ^a,c   Yuan, Ziyan ^a,c   Palermo, Nicholas Y ^a   Dong, Lin ^a   Ahmad, Gulzar ^a   Lokesh, G L ^c   Kolar, Carol ^a   Kizhake, Smitha ^a,c   Borgstahl, Gloria E O ^a   Band, Hamid ^a,b   Natarajan, Amarnath ^c  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CBL PROTEIN; PENTAPEPTIDE; PEPTIDE; PROTEIN TYROSINE KINASE INHIBITOR;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PEPTIDE LIBRARY; PEPTIDOMICS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

BINDING SITES; MODELS, MOLECULAR; OLIGOPEPTIDES; ONCOGENE PROTEIN V-CBL; PEPTIDE LIBRARY; PROTEIN BINDING; PROTEIN-TYROSINE KINASES; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 84859793038     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300078z     Document Type: Article

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