AKAP12 regulates vascular integrity in zebrafish

Experimental and Molecular Medicine

Volumn 44, Issue 3, 2012, Pages 225-235

  Kwon, Hyouk Bum ^a   Choi, Yoon Kyung ^b   Lim, Jhong Jae ^a   Kwon, Seung Hae ^c   Her, Song ^c   Kim, Hyun Jin ^a   Lim, Kyung Joon ^a   Ahn, Jong Chan ^a   Kim, Young Myeong ^b   Bae, Moon Kyung ^d   Park, Jeong Ae ^e   Jeong, Chul Ho ^f   Mochizuki, Naoki ^g   Kim, Kyu Won ^a,h  

^a Seoul National University   (South Korea)

^b Kangwon National University   (South Korea)

^c Korea Basic Science Institute (KBSI)   (South Korea)

^d Pusan National University   (South Korea)

^e Yonsei University   (South Korea)

^f Keimyung University   (South Korea)

^g NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^h Seoul National University   (South Korea)

Author keywords

AKAP12 protein; Animal; Disease models; Hemorrhage; Hemostatic disorders; Human; MLLT4 protein; PAK2 protein; Zebrafish

Indexed keywords

A KINASE ANCHORING PROTEIN 12; MEMBRANE PROTEIN; P21 ACTIVATED KINASE 2; UNCLASSIFIED DRUG;

ACTIN FILAMENT; ANGIOGENESIS; ARTICLE; CELL ADHESION; CONTROLLED STUDY; CYTOSKELETON; ENDOTHELIUM; ENDOTHELIUM CELL; ENZYME REGULATION; FLUORESCENCE IN SITU HYBRIDIZATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; MOLECULAR DYNAMICS; NONHUMAN; PROTEIN ANALYSIS; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; UBIQUITINATION; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULARIZATION; ZEBRA FISH;

ANIMALIA; DANIO RERIO;

EID: 84859772040     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.3858/emm.2012.44.3.017     Document Type: Article

References (26)

1. Aijaz S, Balda MS, Matter K. Tight junctions: molecular architecture and function. Int Rev Cytol 2006;248:261-298
2. Anderson JM, Van Itallie CM. Tight junctions and the molecular basis for regulation of paracellular permeability. Am J Physiol 1995;269:G467-G475
3. Balda MS, Matter K. Tight junctions. J Cell Sci 1998;111: 541-547
4. Bazzoni G, Dejana E. Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis. Physiol Rev 2004;84:869-901
5. Bokoch GM. Biology of the p21-activated kinases. Annu Rev Biochem 2003;72:743-781
6. Buchner DA, Su F, Yamaoka JS, Kamei M, Shavit JA, Barthel LK, McGee B, Amigo JD, Kim S, Hanosh AW, Jagadeeswaran P, Goldman D, Lawson ND, Raymond PA, Weinstein BM, Ginsburg D, Lyons SE. Pak2a mutations cause cerebral hemorrhage in redhead zebrafish. Proc Natl Acad Sci USA 2007;104:13996-14001
7. Choi YK, Kim JH, Kim WJ, Lee HY, Park JA, Lee SW, Yoon DK, Kim HH, Chung H, Yu YS, Kim KW. AKAP12 regulates human blood-retinal barrier formation by downregulation of hypoxia-inducible factor-1alpha. J Neurosci 2007;27: 4472-4481
8. Choi YK, Kim KW. AKAP12 in astrocytes induces barrier functions in human endothelial cells through protein kinase Czeta. FEBS J 2008;275:2338-2353
9. Coniglio SJ, Zavarella S, Symons MH. Pak1 and Pak2 mediate tumor cell invasion through distinct signaling mechanisms. Mol Cell Biol 2008;28:4162-472
10. Corey DR, Abrams JM. Morpholino antisense oligonucleotides: tools for investigating vertebrate development. Genome Biol 2001;2: REVIEWS1015
11. Dejana E. Endothelial cell-cell junctions: happy together. Nat Rev Mol Cell Biol 2004;5:261-270
12. Dejana E, Orsenigo F, Lampugnani MG. The role of adherens junctions and VE-cadherin in the control of vascular permeability. J Cell Sci 2008;121:2115-2122
13. Fukuhara S, Sako K, Minami T, Noda K, Kim HZ, Kodama T, Shibuya M, Takakura N, Koh GY, Mochizuki N. Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1. Nat Cell Biol 2008;10: 513-526
14. Fung SI, Chan JY, Manzoni D, White SR, Lai YY, Strahlendorf HK, Zhuo H, Liu RH, Reddy VK, Barnes CD. Cotransmittermediated locus coeruleus action on motoneurons. Brain Res Bull 1994;35:423-432
15. Lawson ND, Weinstein BM. In vivo imaging of embryonic vascular development using transgenic zebrafish. Dev Biol 2002;248:307-318
16. Liu J, Fraser SD, Faloon PW, Rollins EL, Vom Berg J, Starovic-Subota O, Laliberte AL, Chen JN, Serluca FC, Childs SJ. A betaPix Pak2a signaling pathway regulates cerebral vascular stability in zebrafish. Proc Natl Acad Sci USA 2007;104:13990-13995
17. Murakami M, Simons M. Regulation of vascular integrity. J Mol Med 2009;87:571-582
18. Pellegrin S, Mellor H. Actin stress fibres. J Cell Sci 2007;120: 3491-3499
19. Stockton RA, Schaefer E, Schwartz MA. P21-activated kinase regulates endothelial permeability through modulation of contractility. J Biol Chem 2004;279:46621-46630
20. Taddei A, Giampietro C, Conti A, Orsenigo F, Breviario F, Pirazzoli V, Potente M, Daly C, Dimmeler S, Dejana E. Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5. Nat Cell Biol 2008;10:923-934
21. Trepel M, Stoneham CA, Eleftherohorinou H, Mazarakis ND, Pasqualini R, Arap W, Hajitou A. A heterotypic bystander effect for tumor cell killing after adeno-associated virus/ phage-mediated, vascular-targeted suicide gene transfer. Mol Cancer Ther 2009;8:2383-2391
22. Vestweber D. VE-cadherin: the major endothelial adhesion molecule controlling cellular junctions and blood vessel formation. Arterioscler Thromb Vasc Biol 2008;28:223-232
23. Wallez Y, Huber P. Endothelial adherens and tight junctions Biochim Biophys Acta 2008;1778:794-809
24. Weiser DC, Pyati UJ, Kimelman D. Gravin regulates mesodermal cell behavior changes required for axis elongation during zebrafish gastrulation. Genes Dev 2007; 12:1559-1571
25. Westerfield M. The Zebrafish Book: A Guide for the Laboratory Use of Zebrafish, 3rd Ed, 1995, University of Oregon Press, Eugene, USA
26. Wong W, Scott JD. AKAP signalling complexes: focal points in space and time. Nat Rev Mol Cell Biol 2004;5:959-970