Influence of acetaminophen consumption and exercise on Achilles tendon structural properties in male Wistar rats

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 302, Issue 8, 2012, Pages

  Carroll, Chad C ^a   Whitt, Jamie A ^a   Peterson, Amity ^a   Gump, Brian S ^a   Tedeschi, Jamie ^a   Broderick, Tom L ^a  

^a MIDWESTERN UNIVERSITY   (United States)

Author keywords

Collagen; Cross linking; Hydroxylyslpyridinoline; Hydroxyproline; Stiffness

Indexed keywords

COLLAGEN; HYDROXYLYSLPYRIDINOLINE; HYDROXYPROLINE; PARACETAMOL; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG; WATER;

ACHILLES TENDON; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; EXERCISE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MUSCULOSKELETAL SYSTEM PARAMETERS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CROSS LINKING; RAT; TENDON STIFFNESS; TREADMILL EXERCISE; WATER CONTENT; WISTAR RAT;

ACETAMINOPHEN; ACHILLES TENDON; ANIMALS; BIOMECHANICS; COLLAGEN; MALE; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, WISTAR;

EID: 84859771568     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00659.2011     Document Type: Article

References (56)

1. Alloui A, Chassaing C, Schmidt J, Ardid D, Dubray C, Cloarec A, Eschalier A. Paracetamol exerts a spinal, tropisetron-reversible, antinociceptive effect in an inflammatory pain model in rats. Eur J Pharmacol 443: 71-77, 2002.
2. Bank RA, Beekman B, Verzijl N, de Roos JA, Sakkee AN, TeKoppele JM. Sensitive fluorimetric quantitation of pyridinium and pentosidine crosslinks in biological samples in a single high-performance liquid chromatographic run. J Chromatogr B Biomed Sci Appl 703: 37-44, 1997.
3. Barone R, Bellafiore M, Leonardi V, Zummo G. Structural analysis of rat patellar tendon in response to resistance and endurance training. Scand J Med Sci Sports 19: 782-789, 2009.
4. Biewener AA, Roberts TJ. Muscle and tendon contributions to force, work, and elastic energy savings: a comparative perspective. Exerc Sport Sci Rev 28: 99-107, 2000.
5. Bojsen-Moller J, Magnusson SP, Rasmussen LR, Kjaer M, Aagaard P. Muscle performance during maximal isometric and dynamic contractions is influenced by the stiffness of the tendinous structures. J Appl Physiol 99: 986-994, 2005.
6. Bonnefont J, Alloui A, Chapuy E, Clottes E, Eschalier A. Orally administered paracetamol does not act locally in the rat formalin test: Evidence for a supraspinal, serotonin-dependent antinociceptive mechanism. Anesthesiology 99: 976-981, 2003.
7. Carlstedt CA, Madsen K, Wredmark T. The influence of indomethacin on collagen synthesis during tendon healing in the rabbit. Prostaglandins 32: 353-358, 1986.
8. Carroll CC, Dickinson JM, Lemoine JK, Haus JM, Weinheimer EM, Hollon CJ, Aagaard P, Magnusson SP, Trappe T.A. Influence of acetaminophen and ibuprofen on in vivo patellar tendon adaptations to knee extensor resistance exercise in older adults. J Appl Physiol 111: 508-515, 2011.
9. Chan BP, Fu SC, Qin L, Rolf C, Chan KM. Pyridinoline in relation to ultimate stress of the patellar tendon during healing: an animal study. J Orthop Res 16: 597-603, 1998.
10. Christensen B, Dandanell S, Kjaer M, Langberg H. Effect of anti-inflammatory medication on the running-induced rise in patella tendon collagen synthesis in humans. J Appl Physiol 110: 137-141, 2011.
11. Couppe C, Hansen P, Kongsgaard M, Kovanen V, Suetta C, Aagaard P, Kjaer M, Magnusson SP. Mechanical properties and collagen cross-linking of the patellar tendon in old and young men. J Appl Physiol 107: 880-886, 2009.
12. Davison PF. The contribution of labile crosslinks to the tensile behavior of tendons. Connect Tissue Res 18: 293-305, 1989.
13. Eyre DR, Paz MA, Gallop PM. Cross-linking in collagen and elastin. Annu Rev Biochem 53: 717-748, 1984.
14. Flower RJ, Vane JR. Inhibition of prostaglandin synthetase in brain explains the anti-pyretic activity of paracetamol (4-acetamidophenol). Nature 240: 410-411, 1972.
15. Franchi M, Trire A, Quaranta M, Orsini E, Ottani V. Collagen structure of tendon relates to function. Scientific World J 7: 404-420, 2007.
16. Graham GG, Scott KF. Mechanism of action of paracetamol. Am J Ther 12: 46-55, 2005.
17. Hansen P, Aagaard P, Kjaer M, Larsson B, Magnusson SP. Effect of habitual running on human Achilles tendon load-deformation properties and cross-sectional area. J Appl Physiol 95: 2375-2380, 2003.
18. Haus JM, Carrithers JA, Carroll CC, Tesch PA, Trappe T.A. Contractile and connective tissue protein content of human skeletal muscle: Effects of 35 and 90 days of simulated microgravity and exercise countermeasures. Am J Physiol Regul Integr Comp Physiol 293: R1722-R1727, 2007.
19. Haus JM, Carrithers JA, Trappe SW, Trappe T.A. Collagen, cross-linking, and advanced glycation end products in aging human skeletal muscle. J Appl Physiol 103: 2068-2076, 2007.
20. Haut TL, Haut RC. The state of tissue hydration determines the strain-rate-sensitive stiffness of human patellar tendon. J Biomech 30: 79-81, 1997.
21. Hinz B, Cheremina O, Brune K. Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. FASEB J 22: 383-390, 2008.
22. Jang SH, Lee MH, Lee MG. Pharmacokinetics of acetaminophen after intravenous and oral administration to spontaneously hypertensive rats and normotensive Wistar rats. J Pharm Sci 83: 810-814, 1994.
23. Ker R, Alexander R, Bennett M. Why are mammalian tendons so thick? J Zool Lond 216: 309-324, 1988.
24. Kjaer M. Role of extracellular matrix in adaptation of tendon and skeletal muscle to mechanical loading. Physiol Rev 84: 649-698, 2004.
25. Kongsgaard M, Kovanen V, Aagaard P, Doessing S, Hansen P, Laursen AH, Kaldau NC, Kjaer M, Magnusson SP. Corticosteroid injections, eccentric decline squat training and heavy slow resistance training in patellar tendinopathy. Scand J Med Sci Sports 19: 790-802, 2009.
26. Kongsgaard M, Qvortrup K, Larsen J, Aagaard P, Doessing S, Hansen P, Kjaer M, Magnusson SP. Fibril morphology and tendon mechanical properties in patellar tendinopathy. Am J Sports Med 38: 749-756, 2010.
27. Kongsgaard M, Reitelseder S, Pedersen TG, Holm L, Aagaard P, Kjaer M, Magnusson SP. Region specific patellar tendon hypertrophy in humans following resistance training. Acta Physiol (Oxf) 191: 111-121, 2007.
28. Lange AK, Vanwanseele B, Fiatarone S.M.A. Strength training for treatment of osteoarthritis of the knee: a systematic review. Arthritis Rheum 59: 1488-1494, 2008.
29. Legerlotz K, Schjerling P, Langberg H, Bruggemann GP, Niehoff A. The effect of running, strength, and vibration strength training on the mechanical, morphological, and biochemical properties of the Achilles tendon in rats. J Appl Physiol 102: 564-572, 2007.
30. Lemoine JK, Lee JD, Trappe T.A. Impact of sex and chronic resistance training on human patellar tendon dry mass, collagen content, and collagen cross-linking. Am J Physiol Regul Integr Comp Physiol 296: R119-R124, 2009.
31. Magnusson SP, Hansen P, Kjaer M. Tendon properties in relation to muscular activity and physical training. Scand J Med Sci Sports 13: 211-223, 2003.
32. Magnusson SP, Langberg H, Kjaer M. The pathogenesis of tendinopathy: balancing the response to loading. Nature Rev Rheumatol 6: 262-268, 2010.
33. Magnusson SP, Qvortrup K, Larsen JO, Rosager S, Hanson P, Aagaard P, Krogsgaard M, Kjaer M. Collagen fibril size and crimp morphology in ruptured and intact Achilles tendons. Matrix Biol 21: 369-377, 2002.
34. Meknas K, Johansen O, Steigen SE, Olsen R, Jorgensen L, Kartus J. Could tendinosis be involved in osteoarthritis? Scand J Med Sci Sports 2011 Mar 16. doi: 10.1111/j.1600-0838.2010.01287.x.
35. Michna H. Morphometric analysis of loading-induced changes in collagen-fibril populations in young tendons. Cell Tissue Res 236: 465-470, 1984.
36. Miller BF, Olesen JL, Hansen M, Dossing S, Crameri RM, Welling RJ, Langberg H, Flyvbjerg A, Kjaer M, Babraj JA, Smith K, Rennie MJ. Coordinated collagen and muscle protein synthesis in human patella tendon and quadriceps muscle after exercise. J Physiol 567: 1021-1033, 2005.
37. Muth-Selbach US, Tegeder I, Brune K, Geisslinger G. Acetaminophen inhibits spinal prostaglandin E2 release after peripheral noxious stimulation. Anesthesiology 91: 231-239, 1999.
38. National Research Council Guide for the Care and Use of Laboratory Animals. Washington, DC: National Academy Press, 2011.
39. Reeves ND, Maganaris CN, Narici MV. Effect of strength training on human patella tendon mechanical properties of older individuals. J Physiol 548: 971-981, 2003.
40. Riley G Medscape. Tendinopathy-from basic science to treatment. Nat Clin Pract Rheumatol 4: 82-89, 2008.
41. Riley GP, Cox M, Harrall RL, Clements S, Hazleman BL. Inhibition of tendon cell proliferation and matrix glycosaminoglycan synthesis by non-steroidal anti-inflammatory drugs in vitro. J Hand Surg Br 26: 224-228, 2001.
42. Rosager S, Aagaard P, Dyhre-Poulsen P, Neergaard K, Kjaer M, Magnusson SP. Load-displacement properties of the human triceps surae aponeurosis and tendon in runners and non-runners. Scand J Med Sci Sports 12: 90-98, 2002.
43. Ruwanpura SM, Noguchi K, Ishikawa I. Prostaglandin E2 regulates interleukin-1beta-induced matrix metalloproteinase-3 production in human gingival fibroblasts. J Dent Res 83: 260-265, 2004.
44. Sommer HM. The biomechanical and metabolic effects of a running regime on the Achilles tendon in the rat. Int Orthop 11: 71-75, 1987.
45. Thomas BH, Nera EA, Zeitz W. Failure to observe pathology in the rat following chronic dosing with acetaminophen and acetylsalicylic acid. Res Commun Chem Pathol Pharmacol 17: 663-678, 1977.
46. Tsai WC, Hsu CC, Chang HN, Lin YC, Lin MS, Pang JH. Ibuprofen upregulates expressions of matrix metalloproteinase-1,-8,-9, and-13 without affecting expressions of types I and III collagen in tendon cells. J Orthop Res 28: 487-491, 2010.
47. Tsai WC, Hsu CC, Chen CP, Chen MJ, Lin MS, Pang JH. Ibuprofen inhibition of tendon cell migration and down-regulation of paxillin expression. J Orthop Res 24: 551-558, 2006.
48. Tsai WC, Hsu CC, Chou SW, Chung CY, Chen J, Pang JH. Effects of celecoxib on migration, proliferation and collagen expression of tendon cells. Connect Tissue Res 48: 46-51, 2007.
49. Tsai WC, Tang FT, Hsu CC, Hsu YH, Pang JH, Shiue CC. Ibuprofen inhibition of tendon cell proliferation and upregulation of the cyclin kinase inhibitor p21CIP1. J Orthop Res 22: 586-591, 2004.
50. Voloshenyuk TG, Landesman ES, Khoutorova E, Hart AD, Gardner JD. Induction of cardiac fibroblast lysyl oxidase by TGF-beta1 requires PI3K/Akt, Smad3, and MAPK signaling. Cytokine 55: 90-97, 2011.
51. Wang JH, Iosifidis MI, Fu FH. Biomechanical basis for tendinopathy. Clin Orthop Relat Res 443: 320-332, 2006.
52. Wang XM, Wu TX, Lee YS, Dionne RA. Rofecoxib regulates the expression of genes related to the matrix metalloproteinase pathway in humans: implication for the adverse effects of cyclooxygenase-2 inhibitors. Clin Pharmacol Ther 79: 303-315, 2006.
53. Woo SL, Ritter MA, Amiel D, Sanders TM, Gomez MA, Kuei SC, Garfin SR, Akeson WH. The biomechanical and biochemical properties of swine tendons-long term effects of exercise on the digital extensors. Connect Tissue Res 7: 177-183, 1980.
54. Wood TO, Cooke PH, Goodship AE. The effect of exercise and anabolic steroids on the mechanical properties and crimp morphology of the rat tendon. Am J Sports Med 16: 153-158, 1988.
55. Wu M, Desai DH, Kakarla SK, Katta A, Paturi S, Gutta AK, Rice KM, Walker EM Jr, Blough ER. Acetaminophen prevents aging-associated hyperglycemia in aged rats: effect of aging-associated hyper-activation of p38-MAPK and ERK1/2. Diabetes Metab Res Rev 25: 279-286, 2009.
56. Yoon JH, Halper J. Tendon proteoglycans: biochemistry and function. J Musculoskelet Neuronal Interact 5: 22-34, 2005.