A systematic review of the fetal safety of interferon alpha

Reproductive Toxicology

Volumn 33, Issue 3, 2012, Pages 265-268

  Yazdani Brojeni, P ^a   Matok, I ^a   Garcia Bournissen, F ^a   Koren, G ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Abortion; Interferon alpha; Malformation; Pregnancy

Indexed keywords

ALPHA INTERFERON;

BIRTH WEIGHT; CHILD SAFETY; CHRONIC MYELOID LEUKEMIA; CONGENITAL MALFORMATION; DRUG EFFECT; ENVIRONMENTAL EXPOSURE; FETUS OUTCOME; GESTATIONAL AGE; HAIRY CELL LEUKEMIA; HEPATITIS C; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MATERNAL AGE; MULTIPLE MYELOMA; PREGNANCY COMPLICATION; PREGNANCY OUTCOME; PREMATURE LABOR; PRENATAL EXPOSURE; REVIEW; SPONTANEOUS ABORTION; STILLBIRTH; SYSTEMATIC REVIEW; THROMBOCYTHEMIA;

CONGENITAL ABNORMALITIES; FEMALE; FETUS; HUMANS; INTERFERON-ALPHA; MATERNAL-FETAL EXCHANGE; PREGNANCY; PREGNANCY OUTCOME;

EID: 84859762277     PISSN: 08906238     EISSN: 18731708     Source Type: Journal    
DOI: 10.1016/j.reprotox.2011.11.003     Document Type: Review

References (60)

1. Kiladjian J.J., Chomienne C., Fenaux P. Interferon-alpha therapy in bcr-abl-negative myeloproliferative neoplasms. Leukemia 2008, 22(November (11)):1990-1998.
2. Lenschow D.J., Giannakopoulos N.V., Gunn L.J., Johnston C., O'Guin A.K., Schmid R.E. Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo. J Virol 2005, 79(November (22)):13974-13983.
3. Shiozawa S. Interferon alpha (IFN alpha) treatment for Sjögren's syndrome. Nippon Rinsho 2006, 64(July (7)):1345-1353.
4. Smylie M., Claveau J., Alanen K., Tailleger R., Gearge R., Wong R., et al. Canadian expert panel on malignant melanoma. J Cutan Med Surg 2009, 13(March-April (2)):55-73.
5. Griesshammer M., Struve S., Barbui T. Management of Philadelphia negative chronic myeloproliferative disorders in pregnancy. Blood Rev 2008, 22:235-245.
6. Koh L.P., Devendra K., Tien S.L. Four pregnancies in 2 patients with essential thrombocythemia. Ann Acad Med Singapore 2002, 31:353-356.
7. Martinelli P., Martinelli V., Agangi A., Maruott G.M., Paladini D., Ciancia R., et al. Inteferon alpha treatment for pregnant women affected by essential throbocythemia: case report and review. Am J Obstet Gynecol 2004, 191(December (6)):2016-2020.
8. Beressi A.H., Tefferi A., Silverstein M.N., Petit R.M., Hoagland H.C. Outcome analysis of 34 pregnancies in women with essential thrombocythemia. Adv Intern Med 1995, 155:1217-1222.
9. Cincotta R., Higgins J.R., Tippett C., Gallery E., North R., McMahon L.P., et al. Management of essential thrombocythemia during pregnancy. Aust N Z J Obstet Gynaecol 2000, 40:33-37.
10. Melillo L., Tieghi A., Candoni A., Radaelli F., Ciancia R., Speccia G., et al. Outcome of 122 pregnancies in essential thrombocythemia patients: a report from Italian registry. Am J Hematol 2009, 84(October (10)):636-640.
11. Barbui T., Barosi G., Grossi A., et al. Practice guidelines for the therapy of essential thrombocythemia. A statement from the Italian Society of Hematology, the Italian Society of experimental hematology and the Italian Group for bone marrow transplantation. Hematologica 2004, 89:215-232.
12. Harrison C. Pregnancy and its management in the Philadelphia negative myeloproliferative diseases. Br J Haematol 2005, 129:293-306.
13. Iwashita T., Fujitani M., Yamamoto Y., Katsurada T., Yoshida Y. Interferon alpha treatment of essential thrombocythemia during pregnancy. Intern Med 2006, 45:1879. doi: 10.2169/internal medicine.
14. Milano V., Gabrielli S., Rizzo N., Vianelli N., Gugliotta L., Orsini L.F., et al. Successful treatment of essential thrombocythemia in a pregnancy with recombinant interferon α2α. J Matern Fetal Med 1996, 5:74-78.
15. Nevruz O., Goktolga U., Avcu F., Ozsari L. Multiple gestation in an essential thrombocythemia patient treated with interferon alpha. Acta Obstet Gynecol Scand 2007, 86(7).
16. Mesquita M.M., Pestana A., Mota A. Successful pregnancy occurring with interferon alphatherapy in chronic myeloid leukemia. Acta Obstet Gynecol Scand 2005, 84.
17. Ozaslan E., Yilmaz R., Simsek H., Tatat G. Interferon therapy for acute Hepatitis C during pregnancy. Ann Pharmacother 2002, 36(November).
18. Baykal C., Al A., Demirol A., Bozdag G., Ayhan A. Twin pregnancy after ICSI in a patient with ovarian cancer complicated with materna hepatitis C: case report. Eur J Obstet Gynecol Reprod Biol 2002, 102(April (1)):96-97.
19. Mubarak A.A.S., Kakil I.R., Awidi A., Al-Homsi U., Fawzi Z., Kelta M., et al. Normal outcome of pregnancy in chronic myeloid leukemia treated with interfero α in 1st trimester: report of 3 cases and review of the literature. Am J Hematol 2002, 69:115-118. doi:10.1002/ajh.1191.
20. Roth M.S., Foon K.A. Alpha interferon in the treatment of hematologic malignancies. Am J Med 1986, 81:871-882.
21. Al Bahar S., Pandita R., Nath S.V. Pregnancy in chronic myeloid leukemia patients treated with alpha interferon. Int J Gynecol Obstet 2004, 85:281-282.
22. Vantroyen B., Vanstraelen D. Management of essential thrombocythemia during pregnancy with aspirin, interferon alpha 2a and no treatment. Acta Haematol 2002, 107:158-169.
23. Griesshammer M., Bergmann L., Pearson T.C. Fertility, pregnancy and the management of myeloproliferative disorders. Baillieres Clin Haematol 1998, 11:859-874.
24. Griesshamme M., Grunewald M., Jan J.M. Acquired thrombophilia in pregnancy: essential thrombocythemia. Semin Thromb Hemost 2003, 29(2).
25. Griesshamme M., Heimpel H., Pearson T.C. Essential thrombocythemia and pregnancy. Leuk Lymphoma 1996, 22(Suppl. 1):57-63.
26. Mishkin D., Deschenes M. Conception soon after discontinuing interferon/ribavirin therapy: a successful outcome. Am J Gastroenterol 2001, 96(7).
27. Lebon P., Girard S., Thepot F., Chany C. The presence of alpha interferon in human amniotic fluid. J Gen Virol 1982, 59:393-396.
28. Baer M.R., Ozer H., Kenneth A. Interferon alpha therapy during pregnancy in chronic myelogenous leukemia and hairy cell leukaemia. Br J Haematol 1992, 81:160-167.
29. Williams J.M., Schlesinger P.E., Gray A.G. Successful treatment of essential thrombocythaemia and recurrent abortion with alpha interferon. Br J Haematol 1994, 88(November (3)):647-648.
30. Radi M.L., Barbone E., Girolami A. Normal pregnancy and delivery in essential thrombocythemia even without interferon therapy. Am J Hematol 1994, 45(March (3)):270-271.
31. Petit J.J., Callis M., Fernandez de Sevilla A. Normal pregnancy in a patient with essential thrombocythemia treated with interferon a2b. Am J Hematol 1992, 40:80.
32. Pardini S., Dore F., Murineddu M., Bontigli S., Longinotti M. Alpha 2b interferon therapy and pregnancy - report of a case of essential thrombocythemia. Am J Hematol 1993, 43(May (1)):78-79.
33. Baer M.R. Letter to the editor: normal full term pregnancy in a patient with chronic myelogenous leukemia treated with a interferon. Am J Hematol 1991, 37:66.
34. Pardini S., Careddu M.F., Dore F., Bonfigli S., Gigliotti B., Longinotti M. Essential thrombocythemia and pregnancy. Haematologica 1995, 80(July-August (4)):392-393.
35. Delage R., Demers C., Cantin G., Roy J. Treatment of essential thrombocythemia during pregnancy with interferon a. Obstet Gynecol 1996, 87(May (5Pt 2)):814-817.
36. Cincotta R., Higgins J.R., Tippett C., Gallery E., North R., McMahon L.P., et al. Management of essential thrombocythemia during pregnancy. Aust N Z Gynecol 2000, 40(1):33-37.
37. Skata H., Karamitsos J., Kundaria B., Disaia P.J. Case report of interferon alpha therapy for multiple myeloma during pregnancy. Am J Obstet Gynecol 1995, 172(January (1 Part 1)):217-219.
38. Fritz M., Vats K., Goyal R.K. Neonatal lupus and IUGR following alpha- interferon therapy during pregnancy. J Perinatol 2005, 25:552-554.
39. Hiratsuka M., Minakami H., Koshizuka S., Sato I. Administration of interferon-alpha in pregnancy: effects on fetus. J Perinat Med 2000, 28:372-376.
40. Delage R., Demers C., Caantin G., et al. Treatment of essential thrombocythemia during pregnancy with interferon alpha. Obstet Gynecol 1996, 87:814.
41. Gangat N., Wolanskyi A.P., Schwa Schwager S., Tefferi A. Acquired thrombophilia in pregnancy: essential thrombocythemia. Semin Thromb Hemost 2003, 29(April (2)):205-212.
42. Bellucci S., Janvier M., Tobelem G., et al. Essential thrombocythemias: clinical evaluation and biological data. Cancer 1986, 58:2440.
43. Kaibara M., Kobayashi T., Matsumoto S. Idiopathic thrombocythemia in pregnancy: a report of a case. Obstet Gynecol 1985, 65:18s.
44. Mercer B., Drouin J., Jolly E., et al. Primary thrombocythemia in pregnancy: a report of two cases. Am J Obstet Gynecol 1988, 159:127.
45. Falconer J., Pineo G., Blahey W., et al. Essential thrombocythemia associated with recurrent abortions and fetal growth retardation. Am J Hematol 1987, 25:345.
46. Johnson P.M., Davis J.M., Rand J. Thrombocythemia and recurrent miscarriage. Br J Obstet Gynaecol 1980, 96:1231.
47. Snethlage W., Ten-case J.W. Thrombocythemia and recurrent late abortions: Normal outcome of pregnancies after antiaggregatory treatment: case report. Br J Obstet Gynaecol 1986, 93:386.
48. Lishner M., Amoto D., Farine D. Different outcomes of pregnancy in women with essential thrombocytosis. Isr J Med Sci 1993, 29:100.
49. Okayasu N., Murta M., Ueda A., et al. Primary thrombocythemia and myocardial infarction in a 26 year old woman with normal coronary arterigram. Jpn Heart J 1981, 22:439.
50. Murphy S. Thrombocytosis and thrombocythaemia. Clin Haematol 1983, 12:89.
51. Hoagland H.C., Silverstein M.N. Primary thrombocythemia in the young patient. Mayo Clin Proc 1978, 53:578.
52. Beard J., Hillmen P., Anderson C.C., et al. Primary thrombocythemia in pregnancy. Br J Haematol 1991, 177:371.
53. Ferrai A., Veneziano S., Neri V., et al. Un caso gradidanzo Condetta a termine senza complicanze da una giovane affetta da thrombocythemia primitive. Recenti Prog Med 1986, 77:183.
54. Minkhorst A.G., Novakova I.R.O., Van Dongan P.W.J. Idiopathic thrombocythemia and pregnancy: a case report. Eur J Obstet Gynecol Reprod Biol 1991, 40:237.
55. Rondi M.L., Barbone E., Rossi L., et al. Essential thrombocythemia and pregnancy: a report of six normal pregnancies in 5 untreated patients. Obstet Gynecol 1994, 83:915.
56. Griesshammer M., Grünewald M., Michiels J.J. Acquired thrombophilia in pregnancy: essential thrombocythemia. Semin Thromb Hemost 2003, 29(April (2)):205-212.
57. Harrison C.N. Current trends in essential thrombocythaemi. Br J Haematol 2002, 117:796-808. Summary of 220 reported pregnancies in women with ET.
58. Ananth C.V., Vintzileos A.M. Epidemiology of preterm birth and its clinical subtypes. J Matern Fetal Neonatal Med 2006, 19(December (12)):773-782.
59. Stock S., Norman J. Preterm and term labor in multiple pregnancies. Semin Fetal Neonatal Med 2010, 15(December (6)):336-341.
60. Bar-Oz B., Moretti M.E., Mareels G., Van Tittelboom T., Koren G. Reporting bias in retrospective ascertainment of drug-induced embryopathy. Lancet 1999, 354(November (9191)):1700-1701.