Age difference in morphology and immunohistology in the thymus and spleen in Crl: CD (SD) rats

Journal of Toxicologic Pathology

Volumn 25, Issue 1, 2012, Pages 55-61

  Kodama, Rinya ^a   Okazaki, Takanobu ^a   Sato, Tamio ^a   Iwashige, Shuichiro ^a   Tanigawa, Yohei ^a   Fujishima, Junko ^a   Moriyama, Akiko ^a   Yamashita, Nobuyoshi ^a   Sasaki, Yuji ^a   Yoshikawa, Tsuyoshi ^a   Kamimura, Yasuhiro ^a   Maeda, Hiroshi ^a  

^a SHIN NIPPON BIOMEDICAL LABORATORIES LTD   (Japan)

Author keywords

Development; Immunohistochemistry; Pleen; SD rat; Thymus; Weaning

Indexed keywords

CD3 ANTIGEN; CD45RA ANTIGEN; CD68 ANTIGEN; CYCLINE; NATURAL KILLER CELL RECEPTOR;

AGE; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CELL PROLIFERATION; CONTROLLED STUDY; DEVELOPMENT; FEMALE; IMMUNOHISTOCHEMISTRY; LYMPH FOLLICLE; MALE; MATURATION; MORPHOLOGY; NONHUMAN; RAT; SPLEEN; T LYMPHOCYTE; THYMUS;

EID: 84859762066     PISSN: 09149198     EISSN: None     Source Type: Journal    
DOI: 10.1293/tox.25.55     Document Type: Article

References (15)

1. Immunotoxicity Studies For Human Pharmaceuticals. ICH S8 Guideline Step 5.
2. Harleman JH. Approaches to the identification and recording of findings in the lymphoreticular organs indicative for immunotoxicity in regulatory type toxicity studies. Toxicology. 142: 213-219. 2000. [Medline] [CrossRef]
3. Day MJ. Immune system development in the dog and cat. J Comp Pathol. 137: S10-S15. 2007. [Medline] [CrossRef]
4. Morein B, Abusugra I, and Blomqvist G. Immunity in neonates. Vet Immunol Immunopathol. 87: 207-213. 2002. [Medline] [CrossRef]
5. Morein B, Blomqvist G, and Hu K. Immune responsiveness in the neonatal period. J Comp Pathol. 137: S27-S31. 2007. [Medline] [CrossRef]
6. Singh J, and Singh AK. Age-related changes in human thymus. Clin Exp Immunol. 37: 507-511. 1979. [Medline]
7. Schwander R, Hess MW, Keller HU, and Cottier H. The post-natal development of lymph nodes in mice. Immunobiology. 157: 425-436. 1980. [Medline] [CrossRef]
8. Cheung HT, and Nadakavukaren MJ. Age-dependent changes in the cellularity and ultrastructure of the spleen of Fischer F344 rats. Mech Ageing Dev. 22: 23-33. 1983. [Medline] [CrossRef]
9. Yang TJ, and Gawlak SL. Lymphoid organ weights and organ: body weight ratios of growing beagles. Lab Anim. 23: 143-146. 1989. [Medline] [CrossRef]
10. Spoor MS, Radi ZA, and Dunstan RW. Characterization of age-and gender-related changes in the spleen and thymus from control cynomolgus macaques used in toxicity studies. Toxicol Pathol. 36: 695-704. 2008. [Medline] [Cross-Ref]
11. Baldrick P. Developing drugs for pediatric use: a role for juvenile animal studies? Regul Toxicol Pharmacol. 39: 381-389. 2004. [Medline] [CrossRef]
12. FDA 2006. Guidance for industry nonclinical safety evaluation of pediatric drug products. Document available at http://www.fda.gov/cder/guidance/index.htm.
13. Ji GE. Probiotics in primary prevention of atopic dermatitis. Forum Nutr. 61: 117-128. 2009. [Medline] [CrossRef]
14. Gruver AL, Hudson LL, and Sempowski GD. Immunosenescence of ageing. J Pathol. 211: 144-156. 2007. [Medline] [CrossRef]
15. Bhan AK, Reinherz EL, Poppema S, McCluskey RT, and Schlossman SF. Location of T cell and major histocompatible antigens in the human thymus. J Exp Med. 152: 771-782. 1980. [Medline] [CrossRef]