Effect of aqueous extract of Passiflora edulis on biochemical and hematological parameters of Wistar Albino rats

Toxicology International

Volumn 19, Issue 1, 2012, Pages 63-67

  Devaki, K ^a   Beulah, U ^a   Akila, G ^a   Gopalakrishnan, V K ^a  

^a KARPAGAM UNIVERSITY   (India)

Author keywords

Acute and subacute toxicity studies; hepatotoxic; nephrotoxic; P. edulis

Indexed keywords

AMINOTRANSFERASE; CREATININE; PASSIFLORA EDULIS EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG; UREA; URIC ACID;

ACUTE TOXICITY; AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; BONE MARROW; CONTROLLED STUDY; CREATININE BLOOD LEVEL; ERYTHROCYTE; HEMATOLOGICAL PARAMETERS; LEUKOCYTE; MORTALITY; NONHUMAN; ORGAN WEIGHT; PASSION FRUIT; PLANT LEAF; RAT; THROMBOCYTE; UREA BLOOD LEVEL; URIC ACID BLOOD LEVEL;

ANIMALIA; PASSIFLORA EDULIS; RATTUS;

EID: 84859761975     PISSN: 09716580     EISSN: 09765131     Source Type: Journal    
DOI: 10.4103/0971-6580.94508     Document Type: Article

References (25)

1. Owolabi J, Omogbai EK, Obasuyi O. Antifungal and antibacterial activities of the ethanolic and aqueous extract of Kigelia africana (Bignoniaceae) stem bark. Afr J Biotechnol 2007;6:882-5.
2. Yadav JP, Saini S, Kalia AN, Dangi AS. Hypoglycemic activity of ethanolic extract of Salvadora oleoides in normal and alloxan - induced diabetes rats. Indian J Pharmacol 2008;40:23-7.
3. Nworgu ZA, Onwukaeme DN, Afolayan AJ, Amaechina FC, Ayinde BA. Preliminary studies of blood pressure lowering effect of Nauclea latifolia in rats. Afr J Pharm Phamacol 2008;2:37-41.
4. Lee SI, Oh SH, Park KY, Park BH, Kim JS, Kim SD. Antihyperglycemic effects of fruits of privet (Ligustrum obtusifolium) in streptozotocin - induced diabetic rats fed a high fat diet. J Med Food 2009;12:109-17.
5. Pushparay P, Tan CH, Tan BK. Effect of Averrhoea bilimbi leaf extract on blood glucose and lipid in STZ-diabetic rats. J Ethanopharmacol 2000;72:69-76.
6. Patel SS. Morphology and Pharmacology of Passiflora edulis: A review. J Herb Med Toxicol 2009;3:1-6.
7. Yakuba MT, Akanji MA, Oladiji AT. Effect of oral administration of aquoes extyract of Fadogia agretis stem on some testicular function indices of male rats. J Ethanopharmacol 2008;111:288-92.
8. Sanderson JH, Philips CE. An atlas of laboratory animal haematology. New York: Oxford University Press; 1981. p. 471.
9. Duncan BD. Multiple ranges tests for correlated and heteroscedastic means. Biometrics 1957;13:359-64.
10. Clarke EG, Clarke ML. Landers veterinary toxicology in London. London: Bailliere Tindall; 1997.
11. Zbinden G, Roversi F. Significance of the LD 50 teat for the toxicological evaluation of chemical substances. Arch Toxicol 1981;47:77-99.
12. Schmidt BM, Ilic N, Poulev A, Raskin I. Toxicological evaluation of a chicory root extract. Food Chem Toxicol 2007;45:1131-9.
13. Appidi JR, Yakubu MT, Grierson DS, Afolayan AJ. Toxicological evaluation of aqueous extracts of Hermannia incana Cav. leaves in male wistar rats. Afr J Biotechnol 2009;8:2016-20.
14. Odoula T, Adeniyl FA, Bello IS, Subair HG. Toxicity studies on an unripe Carica papaya aqueous extract: Biochemical and haematological effects in Wister albino rats. J Med Plants Res 2007;1:1-4.
15. Ghosh S, Suryawanshi SA. Effect of Vinica rosea extracts in treatment of alloxan diabetes in male albino rats. Indian J Exp Biol 2001;39:748-59.
16. Ramakrishnan S, Swami R. Text Book of Clinical Biochemistry and Immunology. Chennai: T.R. Publications; 1995. p. 21-7.
17. Will's DE. Biochemical basis of medicine. 3rd ed. Bristol, England: John Wright and Sons Ltd; 1985. p. 267-8.
18. Akanji MA, Yakubu MT. Alpha tocopherol protects against metabisulphite-induced tissue damage in rats. J Biochem Mol Biol 2000;15:179-83.
19. Al-Habori M, AL-Aghbari A, AL-Mamary M, Baker M. Toxicological evaluation of Catha edulis leaves: A long term feeding experiment in animals. J Ethnopharmacol 2002;83:209-17.
20. Sunitha M, Devaki K. Antimicribial activity of Passiflora edulis Sims leaves. Adv Pharmacol Toxicol 2009;10:171-4.
21. Hodek P, Trefil P, Stiborova M. Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450. Chem Biol Interact 2002;139:1-21.
22. Aliyu AB, Ibrahim MA, Musa AM, Ibrahim H, Abdullkadir IE, Oyewale AO. Evalaution of antioxidant activity of leave extract of Bauhinia refurscens Lam. J Med Plant Res 2009;3:563-7.
23. Odabasoglu F, Aslan A, Cakir A, Suleyman HK. Comparision of antioxidant activity and total phenolic content of 3lichen species. Phytother Res 2004;18:938-41.
24. Bever BO. Oral hypoglycaemic plants in West Africa. J Ethanopharmacol 1980;2:119-27.
25. Afolayan AJ, Yakubu MT. Effect of Bulbine natalensis Baker stem extract on the functional indices and histology of the liver and kidney of male Wistar rats. J Med Food 2009;12:814-20.