What should be the optimal cut-off of serum 1,3-β-d-glucan for the detection of invasive pulmonary aspergillosis in patients with haematological malignancies?

Scandinavian Journal of Infectious Diseases

Volumn 44, Issue 5, 2012, Pages 330-336

  Metan, Gökhan ^a   Nedret Koc A ^a   Atalay, Altay ^a   Kaynar, Leyla Gül ^a   Ozturk, Ahmet ^a   Alp, Emine ^a   Eser, Bülent ^a  

^a ERCIYES UNIVERSITY   (Turkey)

Author keywords

1,3 beta; d glucan; Diagnosis of invasive fungal infection; Galactomannan; Haematological malignancy; Invasive pulmonary aspergillosis

Indexed keywords

1,3 BETA GLUCAN SYNTHASE; AMPHOTERICIN B; FLUCONAZOLE; VORICONAZOLE;

ADOLESCENT; ADULT; AGED; CHILD; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; FEMALE; HEMATOLOGIC MALIGNANCY; HUMAN; INFANT; LUNG ASPERGILLOSIS; MAJOR CLINICAL STUDY; MALE; PREDICTIVE VALUE; PRESCHOOL CHILD; REFERENCE VALUE; REVIEW; SCHOOL CHILD; SENSITIVITY AND SPECIFICITY; STEM CELL TRANSPLANTATION;

ADOLESCENT; ADULT; AGED; ANTIGENS, FUNGAL; BETA-GLUCANS; CHILD; CHILD, PRESCHOOL; FEMALE; HEMATOLOGIC NEOPLASMS; HUMANS; INFANT; INVASIVE PULMONARY ASPERGILLOSIS; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; REAGENT KITS, DIAGNOSTIC; ROC CURVE; SENSITIVITY AND SPECIFICITY; YOUNG ADULT;

EID: 84859757572     PISSN: 00365548     EISSN: 16511980     Source Type: Journal    
DOI: 10.3109/00365548.2011.638319     Document Type: Review

References (21)

1. Del Bono V, Mikulska M, Viscoli C. Invasive e aspergillosis: Diagnosis, prophylaxis and treatment. Curr Opin Hematol 2008;16:586-93.
2. Ke? dzierska A, Kochan P, Pietrzyk A, Ke ? dzierska J. Current status of fungal cell wall components in the immunodiagnostics of invasive fungal infections in humans: galactomannan, mannan and (1,3)-beta- D -glucan antigens. Eur J Clin Microbiol Infect Dis 2007;26:755-66.
3. Marty FM, Koo S. Role of (1,3)-beta- D-g lucan in the diagnosis of invasive aspergillosis. Med Mycol 2009;47(Suppl 1): S233 - 40.
4. Karageorgopoulos DE, Vouloumanou EK, Ntziora F, Michalopoulos A, Rafailidis PI, Falagas ME. Beta -D- glucan assay for the diagnosis of invasive fungal infections: A metaanalysis. Clin Infect Dis 2011;52:750-70.
5. Odabasi Z, Mattiuzzi G, Estey E, Kantarjian H, Saeki F, Ridge RJ, et al. Beta -D- glucan as a diagnostic adjunct for invasive fungal infections: Validation, cutoff development, and performance in patients with acute myelogenous leukemia and myelodysplastic syndrome. Clin Infect Dis 2004;39:199-205.
6. Senn L, Robinson JO, Schmidt S, Knaup M, Asahi N, Satomura S, et al. 1,3-Beta -D- glucan antigenemia for early diagnosis of invasive fungal infections in neutropenic patients with acute leukemia. Clin Infect Dis 2008;46: 878-85.
7. Pazos C, Pontón J, Del Palacio A. Contribution of (1,3)-beta -D- glucan chromogenic assay to diagnosis and therapeutic monitoring of invasive aspergillosis in neutropenic adult patients: A comparison with serial screening for circulating galactomannan. J Clin Microbiol 2005;43: 299-305.
8. Ostrosky-Zeichner L, Alexander BD, Kett DH, Vazquez J, Pappas PG, Saeki F, et al. Multicenter clinical evaluation of the (1,3)-beta -D- glucan assay as an aid to diagnosis of fungal infections in humans. Clin Infect Dis 2005;41: 654-9.
9. Alexander BD, Smith PB, Davis RD, Perfect JR, Reller LB. The (1,3)-beta -D- glucan test as an aid to early diagnosis of invasive fungal infections following lung transplantation. J Clin Microbiol 2010;48:4083-8.
10. Racil Z, Kocmanova I, Lengerova M, Weinbergerova B, Buresova L, Toskova M, et al. Diffi culties in using 1,3-{beta} -D- glucan as the screening test for the early diagnosis of invasive fungal infections in patients with haematological malignancies - high frequency of falsepositive results and their analysis. J Med Microbiol 2010; 59:1016-22.
11. De Pauw B, Walsh TJ, Donnelly JP, Stevens DA, Edwards JE, Calandra T, et al. Revised defi nitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group. Clin Infect Dis 2008;46: 1813-21.
12. Hachem RY, Kontoyiannis DP, Chemaly RF, Jiang Y, Reitzel R, Raad I. Utility of galactomannan enzyme immunoassay and (1,3)-beta -D- glucan in diagnosis of invasive fungal infections: Low sensitivity for Aspergillus fumigatus infection in hematologic malignancy patients. J Clin Microbiol 2009;47: 129-33.
13. Koo S, Bryar JM, Page JH, Baden LR, Marty FM. Diagnostic performance of (1,3)-beta -D- glucan assay for invasive fungal disease. Clin Infect Dis 2009;49:1650-9.
14. Kato K, Onoda S, Asano J, Fukaya S, Yoshida S. Evaluation of the clinical cutoff level of serum (1,3)-beta -D- glucan in patients with connective tissue diseases complicated by deep fungal infections. Mod Rheumatol 2010;20: 366-9.
15. Odabasi Z, Paetznick VL, Rodriguez JR, Chen E, McGinnis MR, Ostrosky-Zeichner L. Differences in beta-glucan levels in culture supernatants of a variety of fungi. Med Mycol 2006;44:267-72.
16. Persat F, Ranque S, Derouin F, Michel-Nguyen A, Picot S, Sulahian A. Contribution of the (1,3)-beta -D- glucan assay for diagnosis of invasive fungal infections. J Clin Microbiol 2008;46:1009-13.
17. Marty FM, Lowry CM, Lempitski SJ, Kubiak DW, Finkelman MA, Baden LR. Reactivity of (1,3)-beta- D -glucan assay with commonly used intravenous antimicrobials. Antimicrob Agents Chemother 2006;50:3450-3.
18. Metan G, Agkus C, Buldu H, Koc AN. The interaction between piperacillin/tazobactam and assays for Aspergillus galacto mannan and 1,3-beta -D- glucan in patients without risk factors for invasive fungal infections. Infection 2010; 38:217-21.
19. Iossifova Y, Reponen T, Sucharew H, Succop P, Vesper S. Use of (1 - 3)-beta -D- glucan concentrations in dust as a surrogate method for estimating specific fungal exposures. Indoor Air 2008;18:225-32.
20. Nagano Y, Walker J, Loughrey A, Millar C, Goldsmith C, Rooney P, et al. Identifi cation of airborne bacterial and fungal species in the clinical microbiology laboratory of a university teaching hospital employing ribosomal DNA (rDNA) PCR and gene sequencing techniques. Int. J. Environ Health Res 2009;19:187-99.
21. Kelaher A. Two non-invasive diagnostic tools for invasive aspergillosis: (1 - 3)-beta -D- glucan and the galactomannan assay. Clin Lab Sci 2006;19:222-4.