Etoposide, vincristine, doxorubicin and dexamethasone (EVAD) combination chemotherapy as second-line treatment for advanced AIDS-related Kaposi's sarcoma

Journal of Cancer Research and Clinical Oncology

Volumn 138, Issue 3, 2012, Pages 425-430

  Zhong, Dong Ta ^a,b   Shi, Chun Mei ^a,b   Chen, Qiang ^a,b   Huang, Jing Ze ^a   Liang, Jian Gang ^a   Lin, Dong ^c  

^a FUJIAN MEDICAL UNIVERSITY   (China)

^b Fujian Key Laboratory of Translational Cancer Medicine   (China)

^c FUJIAN PROVINCIAL TUMOR HOSPITAL   (China)

Author keywords

AIDS Kaposi's sarcoma; Combination chemotherapy; Dexamethasone; Doxorubicin; Etoposide; Vincristine

Indexed keywords

BLEOMYCIN; DEXAMETHASONE; DOXORUBICIN; ETOPOSIDE; VINCRISTINE; ANTINEOPLASTIC AGENT; VINBLASTINE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; ADVANCED CANCER; ALKALINE PHOSPHATASE BLOOD LEVEL; ALOPECIA; ANEMIA; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CANCER COMBINATION CHEMOTHERAPY; CANCER GROWTH; CANCER SURVIVAL; DIARRHEA; DISEASE ASSOCIATION; DRUG EFFICACY; DRUG RESPONSE; DRUG SAFETY; DRUG TREATMENT FAILURE; FATIGUE; FEMALE; FOLLOW UP; HUMAN; KAPOSI SARCOMA; LEUKOPENIA; MAJOR CLINICAL STUDY; MALE; MULTIPLE CYCLE TREATMENT; NAUSEA AND VOMITING; NEUROTOXICITY; NEUTROPENIA; OVERALL SURVIVAL; PRIORITY JOURNAL; SIDE EFFECT; THROMBOCYTOPENIA; AIDS RELATED COMPLEX; CHEMICALLY INDUCED DISORDER; DISEASE FREE SURVIVAL; DRUG ADMINISTRATION; PATHOLOGY; RETROSPECTIVE STUDY; TREATMENT FAILURE; TREATMENT OUTCOME;

ADULT; AIDS-RELATED OPPORTUNISTIC INFECTIONS; ANEMIA; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BLEOMYCIN; DEXAMETHASONE; DISEASE-FREE SURVIVAL; DOXORUBICIN; DRUG ADMINISTRATION SCHEDULE; ETOPOSIDE; FEMALE; FOLLOW-UP STUDIES; HUMANS; LEUKOPENIA; MALE; RETROSPECTIVE STUDIES; SARCOMA, KAPOSI; THROMBOCYTOPENIA; TREATMENT FAILURE; TREATMENT OUTCOME; VINBLASTINE; VINCRISTINE;

EID: 84859755720     PISSN: 01715216     EISSN: 14321335     Source Type: Journal    
DOI: 10.1007/s00432-011-1109-7     Document Type: Article

References (16)

1. Beral V, Peterman TA, Berkelman RL, Jaffe HW (1990) Kaposi's sarcaoma among persons with AIDS: a sexually transmitted infection. Lancet 335:123-128 (Pubitemid 20032724)
2. Bower M, Collins S, Cottrill C, Cwynarski K, Montoto S, Nelson M, Nwokolo N, Powles T, Stebbing J, Wales N, Webb A (2008) British HIV association guidelines for HIV-associated malignancies 2008. HIV Med 9:336-388 (Pubitemid 352015641)
3. Brambilla L, Labianca R, Ferrucci SM, Taglioni M, Boneschi V (2001) Treatment of classical Kaposi's sarcoma with gemcitabine. Dermatology 202:119-122 (Pubitemid 32337161)
4. Canellos GP, Petroni GR, Barcos M, Duggan DB, Peterson BA (1995) Etoposide, vinblastine, and doxorubicin: an active regimen for the treatment of Hodgkin's disease in relapse following MOPP. Cancer and Leukemia Group B. J Clin Oncol 13:2005-2011
5. Dezube BJ (1996) Clinical presentation and natural history of AIDS-related Kaposi's sarcoma. Hematol Oncol Clin North Am 10:1023-1029 (Pubitemid 26314132)
6. Di Lorenzo G, Di Trolio R, Montesarchio V, Palmieri G, Nappa P, Delfino M, De Placido S, Dezube BJ (2008) Pegylated liposomal doxorubicin as second-line therapy in the treatment of patients with advanced classic Kaposi sarcoma: a retrospective study. Cancer 112:1147-1152 (Pubitemid 351304601)
7. Evans SR, Krown SE, Testa MA, Cooley TP, Roenn JHV (2002) Phase II evaluation of low-dose oral etoposide for the treatment of relapsed or progressive AIDS-rlated Kaposi's sarcoma: an AIDS clinical trails group clinical study. J Clin Oncol 20:3236-3241 (Pubitemid 34831520)
8. Fardet L, Stoebner PE, Bachelez H, Descamps V, Kerob D, Meunier L, Dandurand M, Morel P, Lebbe C (2006) Treatment with taxanes of refractory or life-threatening Kaposi sarcoma not associated with human immunodeficiency virus infection. Cancer 106:1785-1789
9. Gill PS, Rarick M, McCutchan JA, Slater L, Parker B, Muchmore E, Bemstein-Singer M, Akil B, Espina BM, Krailo M et al (1991) Systemic treatment of AIDS-related Kaposi's sarcoma: results of a randomized trial. Am J Med 90:427-433
10. Goodman GE, Crowley JJ, Blasko JC, Livingston RB, Beck TM, Demattia MD, Bukowski RM (1990) Treatment of limited small-cell lung cancer with etoposide and cisplatin alternating with vincristine, doxorubicin, and cyclophosphamide versus concurrent etoposide, vincristine, doxorubicin, and cyclophosphamide and chest radiotherapy: a Southwest Oncology Group Study. J Clin Oncol 8:39-47 (Pubitemid 20032445)
11. Jones JL, Hanson DL, Dworkin MS, Jaffe HW (2000) Incidence and trends in Kaposi's sarcoma in the era of effective antiretroviral therapy. J Acquir Immune Defic Syndr 24:270-274
12. Laubenstein LS, Krigel RL, Odajnyk CM, Hymes KB, Friedman-kien A, wernz JC, Muggia FM (1984) Treatment of epidemic Kaposi's sarcoma with etoposide or a combination of doxorubicin, bleomycin and vinblastine. J Clin Oncol 2:1115-1120 (Pubitemid 14022699)
13. Papandreou CN, Daliani DD, Thall PF, Tu SM, Wang X, Reyes A, Troncoso P, Logothetis CJ (2002) Results of a phase II study with doxorubicin, etoposide, and cisplatin in patients with fully characterized small-cell carcinoma of the prostate. J Clin Oncol 20:3072-3080 (Pubitemid 34791096)
14. Raina V, Sharma A, Mohanti BK, Kumar R, Dawar R, Rath GK (2003) Etoposide, vinblastine, doxorubicin and prednisolone (EVAP) combination chemotherapy as Wrst-line treatment for Hodgkin's disease. Natl Med J India 16:199-203 (Pubitemid 37304499)
15. Sparano JA, Weller E, Nazeer T, Habermann T, Traynor AE, Manalo J, Cassileth P (2002) Phase 2 trial of infusional cyclophosphamide, doxorubicin, and etoposide in patients with poor-prognosis, intermediate-grade non-Hodgkin lymphoma: an Eastern Cooperative Oncology Group trial (E3493). Blood 100:1634-1640 (Pubitemid 34925139)
16. Volm MD, von Roenn JH (1995) Treatment strategies for epidemic Kaposi's sarcoma. Curr Opin Oncol 7:429-436