Histopathology of incidental findings in beagles used in toxicity studies

Journal of Toxicologic Pathology

Volumn 25, Issue 1, 2012, Pages 103-134

  Sato, Junko ^a   Doi, Takuya ^a   Wako, Yumi ^a   Hamamura, Masao ^a   Kanno, Takeshi ^a   Tsuchitani, Minoru ^a   Narama, Isao ^b  

^a LSI MEDIENCE CORPORATION   (Japan)

^b SETSUNAN UNIVERSITY   (Japan)

Author keywords

Background; Beagle; Histopathology; Incidental; Spontaneous

Indexed keywords

MUCIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERITIS; ARTICLE; DOG; EPIDIDYMIS; FEMALE GENITAL SYSTEM; GALLBLADDER EPITHELIUM; HEART; HISTOPATHOLOGY; INCIDENTAL FINDING; INFLAMMATION; INSULINOMA; LUNG; LYMPHOCYTIC THYROIDITIS; NONHUMAN; PANCREAS; REPRODUCTIVE TOXICITY; SEMINIFEROUS TUBULE; SERTOLI CELL; SPERMATOGENESIS; SPINAL CORD; SPLEEN; TOXICITY TESTING;

EID: 84859749841     PISSN: 09149198     EISSN: None     Source Type: Journal    
DOI: 10.1293/tox.25.103     Document Type: Article

References (29)

1. Jones TC, Hunt RD, and King NW. Veterinary Pathology. 6th ed. Lippincott Williams & Wilkins, Baltimore. 1997.
2. Maxie MG. Jubb, Kennedy, and Palmer's Pathology of Domestic Animals. 5th ed. Elsevier, Philadelphia. 2007.
3. Mohr U, Carlton WW, Dungworth DL, Benjamin SA, Capen CC, and Hahn FF. Pathobiology of the Aging Dog. Iowa State University Press, Ames. 2001.
4. Japanese Society of Veterinary Pathology. Colour Atlas of Animal Pathology. Bun-eido Publishing, Tokyo. 2007. (in Japanese).
5. Gross TL, Ihrke PJ, Walder EJ, and Affolter VK. Skin Diseases of the Dog and Cat: Clinical and Histopathologic Dignosis. Blackwell Science, Oxford. 2005.
6. Meuten DJ. Tumors in Domestic Animals. 4th ed. Iowa State Press, Ames. 2002.
7. Benirschke K, Garner FM, and Jones TC. Pathology of Laboratory Animals. Springer-Verlag, New York. 1978.
8. McGavin MD, and Zachary JF. Pathologic Basis of Veterinary Disease. 4th ed. Elsevier, Philadelphia. 2007.
9. Hottendorf GH, and Hirth RS. Lesions of spontaneous subclinical disease in beagle dogs. Vet Pathol. 11: 240-258. 1974. [Medline] [CrossRef]
10. Maita K, Masuda H, and Suzuki Y. Spontaneous lesions detected in the beagles used in toxicity studies. Exp Anim. 26: 161-167. 1977. [Medline]
11. Yasuba M, Okimoto K, and Iida M. Histopathology of spontaneous lesions in beagles used for toxicity studies. Jpn J Vet Sci. 49: 51-59. 1987. [Medline] [CrossRef]
12. Kobayashi K, Hirouchi Y, Iwata H, Yamakawa S, Mikami S, Yamamoto S, Hashiguchi J, Enomoto M, Shiga A, and Koike Y. Historical control data of spontaneous lesions in beagle dogs. J Toxicol Pathol. 7: 329-343. 1994.
13. Takeda T, Makita T, Nakamura N, and Kimizuka G. Morphologic aspects and morphogenesis of blood cysts on canine cardiac valves. Vet Pathol. 28: 16-21. 1991. [Medline] [CrossRef]
14. Mesfin GM. Spontaneous epicardial fibrous fronds on the atria of beagle dogs. Vet Pathol. 27: 458-461. 1990. [Medline] [CrossRef]
15. Kemi M, Usui T, Narama I, and Takahashi R. Histopathology of spontaneous panarteritis in beagle dogs. Jpn J Vet Sci. 52: 55-61. 1990. [Medline] [CrossRef]
16. Nelson LW, and Kelly WA. Progestogen-related gross and microscopic changes in female beagles. Vet Pathol. 13: 143-156. 1976. [Medline]
17. Rehm S. Spontaneous testicular lesions in purpose-bred beagle dogs. Toxicol Pathol. 28: 782-787. 2000. [Medline] [CrossRef]
18. Goedken MJ, Kerlin RL, and Morton D. Spontaneous and age-related testicular findings in beagle dogs. Toxicol Pathol. 36: 465-471. 2008. [Medline] [CrossRef]
19. Koguchi A, Nomura K, Fujiwara T, Kawai Y, and Okaniwa A. Maternal placenta-like endometrial hyperplasia in a beagle dog (canine deciduoma). Exp Anim. 44: 251-253. 1995. [Medline] [CrossRef]
20. Kajikawa S, Ito K, Nii A, Okamiya H, and Hanada T. Multifocal calcification in the stomach of a beagle dog. J Toxicol Pathol. 13: 265-268. 2000. [CrossRef]
21. Sato J, Tsurukame M, Edamoto H, Kusuoka O, and Tamura K. Spontaneous granular cell tumor of cecum in a laboratory beagle. J Toxicol Pathol. 16: 275-278. 2003. [CrossRef]
22. Katsuta O, Tsuchitani M, and Narama I. Abnormal proliferation of pancreatic endocrine cells in beagle dogs. J Toxicol Pathol. 5: 67-76. 1992.
23. Ohira T, Ishizaki M, Yamakawa S, Iwata H, Imai K, and Enomoto M. A case of pancreatic nesidioblastosis with ab errant istet cell proliferation in a beagle. J Toxicol Pathol. 17: 55-58. 2004. [CrossRef]
24. Yoshizawa K, Oishi Y, Tsubota K, Ieoka K, Fujii T, Ohe O, Senzaki H, and Tsubura A. Latent infection of canine herpes virus in laboratory beagle dogs. J Toxicol Pathol. 13: 1-6. 2000. [CrossRef]
25. Jiang J, Tate Y, Kobayashi Y, and Ichikawa A. Adenomatous hyperplasia of the rete ovarii in a beagle. J Toxicol Pathol. 17: 127-128. 2004. [CrossRef]
26. Zayed I, Gopinath C, Hornstra HW, Spit BJ, and Heijden CA. A light and electron microscopical study of glomerular lipidosis in beagle dogs. J Comp Pathol. 86: 509-517. 1976. [Medline] [CrossRef]
27. Kameda Y. Co-expression of vimentin and 19S-thyroglobulin in follicular cells located in the C-cell complex of dog thyroid gland. J Histochem Cytochem. 43: 1097-1106. 1995. [Medline] [CrossRef]
28. Vajner L, Vortel V, and Brejcha A. Lymphocytic thyroiditis in beagle dogs in a breeding colony: histological findings. Vet Med (Praha). 42: 43-49. 1997. [Medline]
29. Elcock LE, Stuart BP, Hoss HE, Crabb K, Millard DM, Bopp BILL, Mueller RE, Hastings TF, and Lake SG. Renaut bodies in the sciatic nerve of beagle dogs. Exp Toxicol Pathol. 53: 19-24. 2001. [Medline] [CrossRef]