European survey on the use of prophylactic fluconazole in neonatal intensive care units

European Journal of Pediatrics

Volumn 171, Issue 3, 2012, Pages 439-445

  Kaguelidou, Florentia ^a   Pandolfini, Chiara ^b   Manzoni, Paolo ^c   Choonara, Imti ^d   Bonati, Maurizio ^b   Jacqz Aigrain, Evelyne ^a  

^a HÔPITAL ROBERT DEBRÉ   (France)

^b MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^c CITTÀ DELLA SALUTE E DELLA SCIENZA HOSPITAL   (Italy)

^d UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Fluconazole; Intensive care; Neonatology; Prophylaxis; Survey

Indexed keywords

AMPHOTERICIN B; CASPOFUNGIN; CIPROFLOXACIN; FLUCONAZOLE; MICAFUNGIN; MICONAZOLE; NYSTATIN;

ANTIFUNGAL RESISTANCE; BIRTH WEIGHT; CANDIDIASIS; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DRUG EFFICACY; EUROPE; GESTATIONAL AGE; HUMAN; MYCOSIS; NEWBORN; NEWBORN INTENSIVE CARE; PRIORITY JOURNAL; PROPHYLAXIS; REVIEW; STRUCTURED QUESTIONNAIRE;

ANTIFUNGAL AGENTS; CROSS-SECTIONAL STUDIES; DRUG ADMINISTRATION SCHEDULE; EUROPE; FLUCONAZOLE; HUMANS; INFANT, NEWBORN; INTENSIVE CARE UNITS, NEONATAL; INTENSIVE CARE, NEONATAL; MYCOSES; PHYSICIAN'S PRACTICE PATTERNS; QUESTIONNAIRES;

EID: 84859738365     PISSN: 03406199     EISSN: 14321076     Source Type: Journal    
DOI: 10.1007/s00431-011-1565-8     Document Type: Review

References (29)

1. Aghai ZH, Mudduluru M, Nakhla TA, Amendolla B, Lo go D, Kemble N, Kaki S, Sutsko R, Saslow JG, Stahl GE (2006) Fluconazole prophylaxis in extremely low birth weight infants: association with cholestasis. J Perinatol 26:550-555 (Pubitemid 44305065)
2. Austin N, Darlow BA, McGuire W (2009) Prophylactic oral/ topical non-absorbed antifungal agents to prevent invasive fungal infection in very low birth weight infants. Cochrane Database Syst Rev 7:CD003478
3. Benjamin DK Jr, Stoll BJ, Fanaroff AA, McDonald SA, Oh W, Higgins RD, Duara S, Poole K, Laptook A, Goldberg R, Institute N, National Institute of Health and Human Development Neonatal Research Network (2006) Neonatal candidiasis among extremely low birth weight infants: risk factors, mortality rates, and neurodevelopmental outcomes at 18 to 22 months. Pediatrics 117:84-92 (Pubitemid 46050523)
4. Bertini G, Perugi S, Dani C, Filippi L, Pratesi S, Rubaltelli FF (2005) Fluconazole prophylaxis prevents invasive fungal infection in high-risk, very low birth weight infants. J Pediatr 147:162-165 (Pubitemid 41207827)
5. Burwell LA, Kaufman D, Blakely J, Stoll BJ, Fridkin SK (2006) Antifungal prophylaxis to prevent neonatal candidiasis: a survey of perinatal physician practices. Pediatrics 118:e1019-1026 (Pubitemid 46393750)
6. Cabrera C, Frank M, Carter D, Bhatia J (2002) Fluconazole prophylaxis against systemic candidiasis after colonization: a randomised double-blinded study. J Perinatol 22:604
7. Clerihew L, Austin N, McGuire W (2007) Prophylactic systemic antifungal agents to prevent mortality and morbidity in very low birth weight infants. Cochrane database of systematic reviews CD003850
8. Clerihew L, McGuire W (2008) Antifungal prophylaxis for very low birthweight infants: UK national survey. Arch Dis Child Fetal Neonatt Ed 93:F238-239 (Pubitemid 352039296)
9. EU FP7 project: http//www.tin-project.org/.
10. Fridkin SK, Kaufman D, Edwards JR, Shetty S, Horan T (2006) Changing incidence of Candida bloodstream infections among NICU patients in the United States: 1995-2004. Pediatrics 117:1680-1687 (Pubitemid 46071397)
11. Healy CM, Baker CJ, Zaccaria E, Campbell JR (2005) Impact of fluconazole prophylaxis on incidence and outcome of invasive candidiasis in a neonatal intensive care unit. J Pediatr 147:166-171 (Pubitemid 41207828)
12. Healy CM, Campbell JR, Zaccaria E, Baker CJ (2008) Fluconazole prophylaxis in extremely low birth weight neonates reduces invasive candidiasis mortality rates without emergence of fluconazoleresistant Candida species. Pediatrics 121:703-710
13. Kaufman D (2009) Neonatal candidiasis: clinical manifestations, management, and prevention strategies. J Pediatr 156:S47-S52
14. Kaufman DA (2010) Challenging issues in neonatal candidiasis. Curr Med Res Opin 26:1769-1778
15. Kaufman D, Boyle R, Hazen KC, Patrie JT, Robinson M, Donowitz LG (2001) Fluconazole prophylaxis against fungal colonization and infection in preterm infants. N Engl J Med 345:1660-1666 (Pubitemid 33126821)
16. Kaufman D, Boyle R, Hazen KC, Patrie JT, Robinson M, Grossman LB (2005) Twice weekly fluconazole prophylaxis for prevention of invasive Candida infection in high-risk infants of <1000 grams birth weight. J Pediatr 147:172-179 (Pubitemid 41207829)
17. Kicklighter SD, Springer SC, Cox T, Hulsey TC, Turner RB (2001) Fluconazole for prophylaxis against candidal rectal colonization in the very low birth weight infant. Pediatrics 107:293-298 (Pubitemid 32121244)
18. Manzoni P, Arisio R, Mostert M, Leonessa M, Farina D, Latino MA, Gomirato G (2006) Prophylactic fluconazole is effective in preventing fungal colonization and fungal systemic infections in preterm neonates: a single-center, 6-year, retrospective cohort study. Pediatrics 117:e22-32 (Pubitemid 46050500)
19. Manzoni P, Farina D, Leonessa M, d'Oulx EA, Galetto P, Mostert M, Miniero R, Gomirato G (2006) Risk factors for progression to invasive fungal infection in preterm neonates with fungal colonization. Pediatrics 118:2359-2364 (Pubitemid 46397574)
20. Manzoni P, Mostert M, Jacqz-Aigrain E, Farina D (2009) The use of fluconazole in neonatal intensive care units. Arch Dis Child 94:983-987
21. Manzoni P, Stolfi I, Pugni L, Decembrino L, Magnini C, Vetrano G, Tridapalli E, Corona G, Giovannozzi G, Farina D, Arisio R, Merletti F, Maule M, Mosca F, Pedicino R, Stronati M, Mostert M, Gomirato G, Italian Task Force for the Study and Prevention of Neonatal Fungal Infections; Italian Society of Neonatology (2007) A multicenter, randomized trial of prophylactic fluconazole in preterm neonates. N Engl J Med 356:2483-2495 (Pubitemid 46919774)
22. McCrossan BA, McHenry E, O'Neill F, Ong G, Sweet DG (2007) Selective fluconazole prophylaxis in high-risk babies to reduce invasive fungal infection. Arch Dis Child Fetal Neonatal Ed 92: F454-458 (Pubitemid 350044002)
23. Pappas PG, Kauffman CA, Andes D, Benjamin DK Jr, Calandra TF, Edwards JE Jr, Filler SG, Fisher JF, Kullberg BJ, Ostrosky-Zeichner L, Reboli AC, Rex JH, Walsh TJ, Sobel JD, Infectious Diseases Society of America (2009) Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America. Clin Infect Dis 48:503-535
24. Parikh TB, Nanavati RN, Patankar CV, Rao S, Bisure K, Udani RH, Mehta P (2007) Fluconazole prophylaxis against fungal colonization and invasive fungal infection in very low birth weight infants. Indian Pediatr 44:830-837 (Pubitemid 350176034)
25. Stark AR (2004) Levels of neonatal care. Pediatrics 114:1341-1347 (Pubitemid 41647699)
26. Uko S, Soghier LM, Vega M, Marsh J, Reinersman GT, Herring L, Dave VA, Nafday S, Brion LP (2006) Targeted short-term fluconazole prophylaxis among very low birth weight and extremely low birth weight infants. Pediatrics 1117:1243-1252 (Pubitemid 46071518)
27. Van Reempts P, Gortner L, Milligan D, Cuttini M, Petrou S, Agostini R, Field D, den Ouden L, Borch K, Mazela J, Carrapato M, Zeittin J, MOSAIC Research Group (2007) Characteristics of neonatal units that care for very preterm infants in Europe: results from the MOSAIC study. Pediatrics 120:e815-825 (Pubitemid 47549524)
28. Wade KC, Wu D, Kaufman DA, Ward RM, Benjamin DK Jr, Sullivan JE, Ramey N, Javaraman B, Hoppu K, Adamson PC, Gastronguay MR, Barrett JS, National Institute of Child Health and Development Paediatric Pharmacology Research Network (2008) Population pharmacokinetics of fluconazole in young infants. Antimicrob Agents Chemother 52:4043-4049
29. Weitkamp JH, Ozdas A, LaFleur B, Potts AL (2008) Fluconazole prophylaxis for prevention of invasive fungal infections in targeted highest risk preterm infants limits drug exposure. J Perinatol 28:405-411 (Pubitemid 351780934)