New activators and inhibitors in the hair cycle clock: Targeting stem cells state of competence

Journal of Investigative Dermatology

Volumn 132, Issue 5, 2012, Pages 1321-1324

  Plikus, Maksim V ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; CYTOKERATIN 6; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 18; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA2; WNT PROTEIN;

CELL REGENERATION; DERMIS; HAIR FOLLICLE; HAIR GROWTH; MOLECULAR CLOCK; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; STEM CELL;

EID: 84859735359     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2012.38     Document Type: Note

References (16)

1. Blanpain C, Lowry WE, Geoghegan A et al. (2004) Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche. Cell 118:635-48 (Pubitemid 39179715)
2. Botchkarev VA, Botchkareva NV, Nakamura M et al. (2001) Noggin is required for induction of the hair follicle growth phase in postnatal skin. FASEB J 15:2205-14 (Pubitemid 32927938)
3. Brennan T, Dean R, Kavanaugh WM et al. (2011a) Hair growth methods using Fgfr4 extracellular domains. WIPO patent application WO/2011/034940
4. Brennan T, Dean R, Kavanaugh WM et al. (2011b) Hair growth methods using Fgfr3 extracellular domains. WIPO patent application WO/2011/084711
5. Enshell-Seijffers D, Lindon C, Kashiwagi M et al. (2010) b-catenin activity in the dermal papilla regulates morphogenesis and regeneration of hair. Dev Cell 18:633-42
6. Festa E, Fretz J, Berry R et al. (2011) Adipocyte lineage cells contribute to the skin stem cell niche to drive hair cycling. Cell 146:761-71
7. Garza LA, Yang CC, Zhao T et al. (2011) Bald scalp in men with androgenetic alopecia retains hair follicle stem cells but lacks CD200-rich and CD34-positive hair follicle progenitor cells. J Clin Invest 121:613-22
8. Geyfman M, Gordon W, Paus R et al. (2012) Identification of telogen markers underscores that telogen is far from a quiescent hair cycle phase. J Invest Dermatol 132:721-4
9. Greco V, Chen T, Rendl M et al. (2009) A two-step mechanism for stem cell activation during hair regeneration. Cell Stem Cell 4:155-69
10. Hsu YC, Pasolli HA, Fuchs E (2011) Dynamics between stem cells, niche, and progeny in the hair follicle. Cell 144:92-105
11. Kawano M, Komi-Kuramochi A, Asada M et al. (2005) Comprehensive analysis of FGF and FGFR expression in skin: FGF18 is highly expressed in hair follicles and capable of inducing anagen from telogen stage hair follicles. J Invest Dermatol 124:877-85 (Pubitemid 40629085)
12. Kimura-Ueki M, Oda Y, Oki J et al. (2012) Hair cycle resting phase is regulated by cyclic epithelial FGF18 signaling. J Invest Dermatol 132:1338-45
13. Lowry WE, Blanpain C, Nowak JA et al. (2005) Defining the impact of beta-catenin/Tcf transactivation on epithelial stem cells. Genes Dev 19:1596-611 (Pubitemid 41003002)
14. Oshimori N, Fuchs E (2012) Paracrine TGF-b signaling counterbalances BMP-mediated repression in hair follicle stem cell activation. Cell Stem Cell 10:63-75
15. Plikus MV, Baker RE, Chen CC et al. (2011) Self-organizing and stochastic behaviors during the regeneration of hair stem cells. Science 332:586-9
16. Plikus MV, Mayer JA, de la Cruz D et al. (2008) Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration. Nature 451:340-4