Reprogramming of gastrointestinal cancer cells

Cancer Science

Volumn 103, Issue 3, 2012, Pages 393-399

  Dewi, DyahLaksmi ^a   Ishii, Hideshi ^a   Haraguchi, Naotsugu ^a   Nishikawa, Shimpei ^a   Kano, Yoshihiro ^a   Fukusumi, Takahito ^a   Ohta, Katsuya ^a   Miyazaki, Susumu ^a   Ozaki, Miyuki ^a   Sakai, Daisuke ^a   Satoh, Taroh ^a   Nagano, Hiroaki ^a   Doki, Yuichiro ^a   Mori, Masaki ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2;

BLASTOCYST; CANCER CELL; CANCER STEM CELL; CELL CYCLE CHECKPOINT; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL TRANSFORMATION; DIGESTIVE SYSTEM CANCER; DNA METHYLATION; ECTODERM; EPIGENETICS; EPITHELIAL MESENCHYMAL TRANSITION; GENE EXPRESSION; GENE TRANSFER; HUMAN; NONHUMAN; PHENOTYPE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REVIEW; SOMATIC CELL; TUMOR CELL; TUMOR SUPPRESSOR GENE; ANIMAL; GASTROINTESTINAL TUMOR; GENETIC EPIGENESIS; GENETICS; PATHOLOGY;

ANIMALS; CELL DIFFERENTIATION; CELL TRANSFORMATION, NEOPLASTIC; EPIGENESIS, GENETIC; EPITHELIAL-MESENCHYMAL TRANSITION; GASTROINTESTINAL NEOPLASMS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; NEOPLASTIC STEM CELLS;

EID: 84859723749     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2011.02184.x     Document Type: Review

References (90)

1. Reik W, Dean W, Walter J. Epigenetic reprogramming in mammalian development. Science 2001; 293: 1089-93.
2. Vogelstein B, Kinzler KW. The multistep nature of cancer. Trends Genet 1993; 9: 138-41.
3. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100: 57-70.
4. Barker N, Ridgway RA, van Es JH et al. Crypt stem cells as the cells-oforigin of intestinal cancer. Nature 2009; 457: 608-11.
5. Irons RD, Stillman WS. The process of leukemogenesis. Environ Health Perspect 1996; 104 (Suppl 6): 1239-6.
6. Bonnet D, Dick JE. Human acute leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 1997; 3: 730-37.
7. Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature 2001; 414: 105-11.
8. Kasemeier-Kulesa JC, Teddy JM, Postovit LM et al. Reprogramming multipotent tumor cells with the embryonic neural crest microenvironment. Dev Dyn 2008; 237: 2657-66.
9. Lin SL, Chang DC, Chang-Lin S et al. Mir-302 reprograms human skin cancer cells into a pluripotent ES-cell-like state. RNA 2008; 14: 2115-24.
10. Miyoshi N, Ishii H, Nagai K et al. Defined factors induce reprogramming of gastrointestinal cancer cells. Proc Natl Acad Sci USA 2010; 107: 40-5.
11. Wang J, Emadali A, Le Bescont A, Callanan M, Rousseaux S, Khochbin S. Induced malignant genome reprogramming in somatic cells by testis-specific factors. Biochim Biophys Acta 2011; 1809: 221-5.
12. Ben-David U, Benvenisty N. The tumorigenicity of human embryonic and induced pluripotent stem cells. Nat Rev Cancer 2011; 11: 268-77.
13. Surani MA, Hayashi K, Hajkova P. Genetic and epigenetic regulators of pluripotency. Cell 2007; 128: 747-62.
14. Rasmussen TP, Corry GN. Epigenetic pre-patterning and dynamics during initial stages of mammalian preimplantation development. J Cell Physiol 2010; 225: 333-6.
15. Surani MA, Durcova-Hills G, Hajkova P, Hayashi K, Tee WW. Germ line, stem cells, and epigenetic reprogramming. Cold Spring Harb Symp Quant Biol 2008; 73: 9-15.
16. Evans MJ, Kaufman MH. Establishment in culture of pluripotential cells from mouse embryos. Nature 1981; 292: 154-6.
17. Martin GR. Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc Natl Acad Sci USA 1981; 78: 7634-8.
18. Thomson JA, Itskovitz-Eldor J, Shapiro SS et al. Embryonic stem cell lines derived from human blastocysts. Science 1998; 282: 1145-7.
19. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006; 126: 663-76.
20. Takahashi K, Tanabe K, Ohnuki M et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007; 131: 861-72.
21. Beers MF, Morrisey EE. The three R's of lung health and disease: repair, remodeling, and regeneration. J Clin Invest 2011; 121: 2065-73.
22. Herdrich BJ, Lind RC, Liechty KW. Multipotent adult progenitor cells: their role in wound healing and the treatment of dermal wounds. Cytotherapy 2008; 10: 543-50.
23. Medema JP, Vermeulen L. Microenvironmental regulation of stem cells in intestinal homeostasis and cancer. Nature 2011; 474: 318-26.
24. Houbaviy HB, Murray MF, Sharp PA. Embryonic stem cell-specific MicroRNAs. Dev Cell 2003; 5: 351-8.
25. Mattick JS, Makunin IV. Non-coding RNA. Hum Mol Genet 2006; 1: R17-29.
26. Leung AK, Sharp PA. MicroRNA functions in stress responses. Mol Cell 2010; 40: 205-15.
27. Okita K, Ichisaka T, Yamanaka S. Generation of germline-competent induced pluripotent stem cells. Nature 2007; 448: 313-7.
28. Wernig M, Meissner A, Foreman R et al. In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature 2007; 448: 318-24.
29. Gil J, Peters G. Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all. Nature Rev Mol Cell Biol 2006; 7: 667-77.
30. Krimpenfort P, IJpenberg A, Song JY, van der Valk M, Nawijn M, Zevenhoven J. Berns A. p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a. Nature 2007; 448: 943-6.
31. Utikal J, Polo JM, Stadtfeld M et al. Immortalization eliminates a roadblock during cellular reprogramming into iPS cells. Nature 2009; 460: 1145-8.
32. Li H, Collado M, Villasante A et al. The Ink4/Arf locus is a barrier for iPS cell reprogramming. Nature 2009; 460: 1136-9.
33. Hong H, Takahashi K, Ichisaka T et al. Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature 2009; 460: 1132-5.
34. Kawamura T, Suzuki J, Wang YV et al. Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Nature 2009; 460: 1140-4.
35. Marión RM, Strati K, Li H et al. A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity. Nature 2009; 460: 1149-53.
36. Mali P, Chou B.-K, Yen J et al. Butyrate Greatly Enhances Derivation of Human Induced Pluripotent Stem Cells by Promoting Epigenetic Remodeling and the Expression of Pluripotency-Associated Genes. Stem Cell 2010; 28: 713-20.
37. Esteban MA, Wang T, Qin B et al. Vitamin C Enhances the Generation of Mouse and Human Induced Pluripotent Stem Cells. Cell Stem Cell 2010; 6: 71-9.
38. Yoshida Y, Takahashi K, Okita K, Ichisaka T, Yamanaka S. Hypoxia enhances the generation of induced pluripotent stem cells. Cell Stem Cell 2009; 5: 237-41.
39. Anokye-Danso F, Trivedi CM, Juhr D et al. Highly efficient miRNAmediated reprogramming of mouse and human somatic cells to pluripotency. Cell Stem Cell 2011; 8: 376-88.
40. Lin SL, Chang DC, Lin CH, Ying SY, Leu D, Wu DT. Regulation of somatic cell reprogramming through inducible mir-302 expression. Nucleic Acids Res 2011; 39: 1054-65.
41. Okita K, Nakagawa M, Hyenjong H, Ichisaka T, Yamanaka S. Generation of mouse induced pluripotent stem cells without viral vectors. Science 2008; 322: 949-53.
42. Kaji K, Norrby K, Paca A, Mileikovsky M, Mohseni P, Woltjen K. Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Nature 2009; 458: 771-5.
43. Woltjen K, Michael IP, Mohseni P et al. piggybac transposition reprograms fibroblasts to induced pluripotent stem cells. Nature 2009; 458: 766-70.
44. Jia F, Wilson KD, Sun N et al. A nonviral minicircle vector for deriving human iPS cells. Nat Methods 2010; 7: 197-9.
45. Seki T, Yuasa S, Oda M et al. Generation of induced pluripotent stem cells from human terminally differentiated circulating T cells. Cell Stem Cell 2010; 7: 11-4.
46. Fusaki N, Ban H, Nishiyama A, Saeki K, Hasegawa M. Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome. Proc Jpn Acad Ser B Phys Biol Sci 2009; 85: 348-62.
47. Ban H, Nishishita N, Fusaki N et al. Efficient generation of transgene-free human induced pluripotent stem cells (iPSCs) by temperature-sensitive Sendai virus vectors. Proc Natl Acad Sci USA 2011; 108: 14234-9.
48. Kim D, Kim CH, Moon JI et al. Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins. Cell Stem Cell 2009; 4: 472-6.
49. Zhou H, Wu S, Joo JY et al. Generation of induced pluripotent stem cells using recombinant proteins. Cell Stem Cell 2009; 4: 381-4.
50. Warren L, Manos PD, Ahfeldt T et al. Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell 2010; 7: 618-30.
51. Miyoshi N, Ishii H, Nagano H et al. Reprogramming of mouse and human cells to pluripotency using mature microRNAs. Cell Stem Cell 2011; 8: 633-8.
52. Ambros V. The functions of animal microRNAs. Nature 2004; 431: 350-5.
53. John B, Enright AJ, Aravin A, Tuschl T, Sander C, Marks DS. Human MicroRNA targets. PLoS Biol 2004; 2: e363.
54. Vasudevan S, Tong Y, Steitz JA. Switching from Repression to Activation: microRNAs Can Up-Regulate Translation. Science 2007; 318: 1931-4.
55. Liao B, Bao X, Liu L et al. MicroRNA cluster 302-367 enhances somatic cell reprogramming by accelerating a mesenchymal-to-epithelial transition. J Biol Chem 2011; 286: 17359-64.
56. Li R, Liang J, Ni S et al. A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts. Cell Stem Cell 2010; 7: 51-63.
57. Nagai K-I, Ishii H, Miyoshi N et al. Long-term culture following ES-like gene-induced reprogramming elicits an aggressive phenotype in mutated cholangiocellular carcinoma cells. BiochemBiophysic Res Commun 2010; 395: 258-63.
58. Zhao Y, Yin X, Qin H et al. Two supporting factors greatly improve the efficiency of human iPSC generation. Cell Stem Cell 2008; 3: 475-9.
59. Moon JH, Ishii H, Dewi DL et al. Gain-of-function oncogenic mutations in TP53 enhance defined factor-mediated cellular reprogramming. Nature Precedings, 2011.
60. Lin SL, Chang DC, Ying SY, Leu D, Wu DT. MicroRNA miR-302 inhibits the tumorigenecity of human pluripotent stem cells by coordinate suppression of the CDK2 and CDK4/6 cell cycle pathways. Cancer Res 2010; 70: 9473-82.
61. Fareh M, Turchi L, Virolle V et al. The miR 302-367 cluster drastically affects self-renewal and infiltration properties of glioma-initiating cells through CXCR4 repression and consequent disruption of the SHH-GLINANOG network. Cell Death Differ 2011; DOI: 10.1038/cdd.2011.89. [Epub ahead of print].
62. Li L, Clevers H. Coexistence of quiescent and active adult stem cells in mammals. Science 2010; 327: 542-5.
63. Arai F, Hirao A, Ohmura M et al. Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell 2004; 118: 149-61.
64. Fuchs E, Segre JA. Stem cells: a new lease on life. Cell 2000; 100: 143-55.
65. Haraguchi N, Ishii H, Mimori K et al. CD13 is a therapeutic target in human liver cancer stem cells. J Clin Invest 2010; 120: 3326-39.
66. Ben-Porath I, Thomson MW, Carey VJ et al. An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet 2008; 40: 499-507.
67. Ratajczak MZ, Shin DM, Liu R et al. Epiblast/germ line hypothesis of cancer development revisited: lesson from the presence of Oct-4+ cells in adult tissues. Stem Cell Rev 2010; 6: 307-16.
68. Kuroda Y, Kitada M, Wakao S et al. Unique multipotent cells in adult human mesenchymal cell populations. Proc Natl Acad Sci USA 2010; 107: 8639-43.
69. Wakao S, Kitada M, Kuroda Y et al. Multilineage-differentiating stressenduring (Muse) cells are a primary source of induced pluripotent stem cells in human fibroblasts. Proc Natl Acad Sci USA 2011; 108: 9875-80.
70. Yamanaka S. Elite and stochastic models for induced pluripotent stem cell generation. Nature 2009; 460: 49-52.
71. Yu J, Vodyanik MA, Smuga-Otto K et al. Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells. Science 2007; 318: 1917-20.
72. Stadtfeld M, Nagaya M, Utikal J, Weir G, Hochedlinger K. Induced pluripotent stem cells generated without viral integration. Science 2008; 322: 945-9.
73. Aoi T, Yae K, Nakagawa M et al. Generation of pluripotent stem cells from adult mouse liver and stomach cells. Science 2008; 321: 699-702.
74. Kim JB, Zaehres H, Wu G et al. Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors. Nature 2008; 454: 646-50.
75. Huangfu D, Maehr R, Guo W et al. Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat Biotechnol 2008; 26: 795-7.
76. Wernig M, Lengner CJ, Hanna J et al. A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types. Nat Biotechnol 2008; 26: 916-24.
77. Sun N, Panetta NJ, Gupta DM et al. Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells. Proc Natl Acad Sci USA 2009; 106: 15720-5.
78. Shi Y, Do JT, Desponts C, Hahm HS, Schöler HR, Ding S. A combined chemical and genetic approach for the generation of induced pluripotent stem cells. Cell Stem Cell 2008; 2: 525-8.
79. Judson RL, Babiarz JE, Venere M, Blelloch R. Embryonic stem cell-specific microRNAs promote induced pluripotency. Nat Biotechnol 2009; 27: 459-61.
80. Zhu S, Li W, Zhou H et al. Reprogramming of human primary somatic cells by OCT4 and chemical compounds. Cell Stem Cell 2010; 7: 651-5.
81. Li Z, Yang CS, Nakashima K, Rana TM. Small RNA-mediated regulation of iPS cell generation. EMBO J 2011; 30: 823-34.
82. Subramanyam D, Lamouille S, Judson RL et al. Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells. Nat Biotechnol 2011; 29: 443-8.
83. Li L, Connelly MC, Wetmore C, Curran T, Morgan JI. Mouse embryos cloned from brain tumors. Cancer Res 2003; 63: 2733-36.
84. Hochedlinger K, Blelloch R, Brennan C et al. Reprogramming of a melanoma genome by nuclear transplantation. Genes Dev 2004; 18: 1875-85.
85. Blelloch RH, Hochedlinger K, Yamada Y et al. Nuclear cloning of embryonal carcinoma cells. Proc Natl Acad Sci USA 2004; 101: 13985-90.
86. Postovit LM, Margaryan NV, Seftor EA et al. Human embryonic stem cell microenvironment suppresses the tumorigenic phenotype of aggressive cancer cells. Proc Natl Acad Sci USA 2008; 105: 4329-34.
87. Utikal J, Maherali N, Kulalert W, Hochedlinger K. Sox2 is dispensable for the reprogramming of melanocytes and melanoma cells into induced pluripotent stem cells. J Cell Sci 2009; 122: 3502-10.
88. Carette JE, Pruszak J, Varadarajan M, Blomen VA, Gokhale S. Generation of iPSCs from cultured human malignant cells. Blood 2010; 115: 4039-42.
89. Mathieu J, Zhang Z, Zhou W, Wang AJ, Heddleston JM. HIF induces human embryonic stem cell markers in cancer cells. Cancer Res 2011; 71: 4640-52.
90. Allegrucci C, Rushton MD, Dixon JE et al. Epigenetic reprogramming of breast cancer cells with oocyte extracts. Mol Cancer 2011; 10: 7.